Gene/Proteome Database (LMPD)

LMPD ID
LMP009111
Gene ID
34136
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG7840 gene product from transcript CG7840-RA
Gene Symbol
CG7840
Synonyms
cg7840; Dmel\CG7840
Alternate Names
CG7840; CG7840-PA
Chromosome
2L
Map Location
29A3-29A3
EC Number
1.3.1.94

Proteins

CG7840
Refseq ID NP_609203
Protein GI 20129365
UniProt ID Q9VLP9
mRNA ID NM_135359
Length 326
RefSeq Status REVIEWED
MAPPENGILEVLENLLDRYKINLLQMMFGTFIATIVFFGGLMTFVEKYLPNSIRQSFRYGKHSFKGETDPLVAWLEVPKSWFKHFYTFALFWSWLAFYVLVSTVREQKEAPEYVLQFLDIMGGGRSHRKVEIDSTTACVGAFMLTLQCTRRFYETNFVQIFSKKSKINLSHYAVGYVHYFGAVIALLSNTSGFVRGSKPMEFSLDKLTSQQILYLGVFFLAWQQQYASNMILVNLRKDPRTGSVKTEKHLLPKGGLFNLLSSPHMFLEVVMYFCIADLYMPVRIWRLIFLWVASNQTINALLTHKWYQETFREYPKNRRAIIPFLL

Gene Information

Entrez Gene ID
34136
Gene Name
CG7840 gene product from transcript CG7840-RA
Gene Symbol
CG7840
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016627 IEA:InterPro F oxidoreductase activity, acting on the CH-CH group of donors
GO:0019348 ISS:UniProtKB P dolichol metabolic process
GO:0006488 ISS:UniProtKB P dolichol-linked oligosaccharide biosynthetic process
GO:0016095 ISS:UniProtKB P polyprenol catabolic process
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

REACTOME Pathway Links

REACTOME Pathway ID Description
6226425 Androgen biosynthesis
6226422 Metabolism of steroid hormones and vitamin D
6226409 Synthesis of Dolichyl-phosphate
6226410 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal

UniProt Annotations

Entry Information

Gene Name
CG7840 gene product from transcript CG7840-RA
Protein Entry
PORED_DROME
UniProt ID
Q9VLP9
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity Ditrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH.
Function Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). {ECO:0000250}.
Interaction Q9XYQ2:unc-119; NbExp=1; IntAct=EBI-88569, EBI-127298;
Pathway Protein modification; protein glycosylation.
Sequence Caution Sequence=AAM52687.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009111 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20129365 RefSeq NP_609203 326 CG7840

Identical Sequences to LMP009111 proteins

Reference Database Accession Length Protein Name
GI:20129365 gnl FlyBase 326 CG7840 [Drosophila melanogaster]
GI:20129365 SwissProt Q9VLP9.1 326 RecName: Full=Polyprenol reductase [Drosophila melanogaster]

Related Sequences to LMP009111 proteins

Reference Database Accession Length Protein Name
GI:20129365 EMBL CAL26219.1 326 CG7840 [Drosophila melanogaster]
GI:20129365 EMBL CAL26230.1 326 CG7840 [Drosophila melanogaster]
GI:20129365 EMBL CAL26235.1 326 CG7840 [Drosophila melanogaster]
GI:20129365 EMBL CAL26237.1 326 CG7840 [Drosophila melanogaster]
GI:20129365 EMBL CAR93292.1 326 CG7840-PA [Drosophila melanogaster]
GI:20129365 GenBank AAM52687.1 353 LD35060p, partial [Drosophila melanogaster]