Gene/Proteome Database (LMPD)

LMPD ID
LMP009052
Gene ID
34358
Species
Drosophila melanogaster (Drosophila)
Gene Name
Niemann-Pick type C-1a
Gene Symbol
Npc1a
Synonyms
CG5722; Dmel\CG5722; DmNPC; dmNPC1; dncp1a; dNPC1; dnpc1a; dNPC1a; npc1; Npc1; NPC1; npc1a; NPC1a; Npc1_Dm
Chromosome
2L
Map Location
31B1-31B1

Proteins

Niemann-Pick type C-1a, isoform A
Refseq ID NP_609357
Protein GI 24583258
UniProt ID Q9VL24
mRNA ID NM_135513
Length 1287
RefSeq Status REVIEWED
MSPRSPLRISPFGVHILIAAVLFTLIQSSKQDCVWYGVCNTNDFSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENSENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYFVIMAAVFLVGVLVFLMGSFLFTQGSSMDDNFQVDGNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDEDNGFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQDTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARLRYHSQAAAEHETALAGIL
Niemann-Pick type C-1a, isoform B
Refseq ID NP_001188769
Protein GI 320544872
UniProt ID Q9VL24
mRNA ID NM_001201840
Length 1287
RefSeq Status REVIEWED
MSPRSPLRISPFGVHILIAAVLFTLIQSSKQDCVWYGVCNTNDFSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENSENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYFVIMAAVFLVGVLVFLMGSFLFTQGSSMDDNFQVDGNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDEDNGFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQDTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARLRYHSQAAAEHETALAGIL
Niemann-Pick type C-1a, isoform C
Refseq ID NP_001188770
Protein GI 320544874
UniProt ID Q9VL24
mRNA ID NM_001201841
Length 1287
RefSeq Status REVIEWED
Protein sequence is identical to GI:320544872 (mRNA isoform)
Niemann-Pick type C-1a, isoform D
Refseq ID NP_001188771
Protein GI 320544876
UniProt ID Q9VL24
mRNA ID NM_001201842
Length 1287
RefSeq Status REVIEWED
Protein sequence is identical to GI:320544872 (mRNA isoform)
Niemann-Pick type C-1a, isoform E
Refseq ID NP_001285795
Protein GI 665407386
UniProt ID X2J9B0
mRNA ID NM_001298866
Length 1283
RefSeq Status REVIEWED
MSPRSPLRISPFGVHILIAAVLFTLIQSSKQDCVWYGVCNTNDFSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENSENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYFVIMAAVFLVGVLVFLMGSFLFTQDDNFQVDGNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDEDNGFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQDTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARLRYHSQAAAEHETALAGIL
Niemann-Pick type C-1a, isoform F
Refseq ID NP_001285796
Protein GI 665407388
UniProt ID X2J9B0
mRNA ID NM_001298867
Length 1283
RefSeq Status REVIEWED
Protein sequence is identical to GI:665407386 (mRNA isoform)
Niemann-Pick type C-1a, isoform G
Refseq ID NP_001285797
Protein GI 665407390
UniProt ID X2J9B0
mRNA ID NM_001298868
Length 1283
RefSeq Status REVIEWED
Protein sequence is identical to GI:665407386 (mRNA isoform)

Gene Information

Entrez Gene ID
34358
Gene Name
Niemann-Pick type C-1a
Gene Symbol
Npc1a
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:InterPro C integral component of membrane
GO:0008158 IEA:InterPro F hedgehog receptor activity
GO:0030301 IEA:InterPro P cholesterol transport
GO:0045456 IMP:FlyBase P ecdysteroid biosynthetic process
GO:0007591 IMP:FlyBase P molting cycle, chitin-based cuticle
GO:0032374 IDA:FlyBase P regulation of cholesterol transport
GO:0007291 IMP:FlyBase P sperm individualization
GO:0016125 IMP:FlyBase P sterol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
dme04142 Lysosome
ko04142 Lysosome

Domain Information

InterPro Annotations

Accession Description
IPR004765 Niemann-Pick C type protein
IPR003392 Patched
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
Niemann-Pick type C-1a
Protein Entry
Q9VL24_DROME
UniProt ID
X2J9B0
Species
Drosophila

Identical and Related Proteins

Unique RefSeq proteins for LMP009052 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24583258 RefSeq NP_609357 1287 Niemann-Pick type C-1a, isoform A
320544872 RefSeq NP_001188769 1287 Niemann-Pick type C-1a, isoform B
665407386 RefSeq NP_001285795 1283 Niemann-Pick type C-1a, isoform E

Identical Sequences to LMP009052 proteins

Reference Database Accession Length Protein Name
GI:320544872 gnl FlyBase 1287 Niemann-Pick type C-1a, isoform B [Drosophila melanogaster]
GI:24583258 gnl FlyBase 1287 Niemann-Pick type C-1a, isoform B [Drosophila melanogaster]
GI:24583258 gnl FlyBase 1287 Niemann-Pick type C-1a, isoform C [Drosophila melanogaster]
GI:320544872 gnl FlyBase 1287 Niemann-Pick type C-1a, isoform C [Drosophila melanogaster]
GI:320544872 gnl FlyBase 1287 Niemann-Pick type C-1a, isoform D [Drosophila melanogaster]
GI:24583258 gnl FlyBase 1287 Niemann-Pick type C-1a, isoform D [Drosophila melanogaster]
GI:665407386 gnl FlyBase 1283 Niemann-Pick type C-1a, isoform E [Drosophila melanogaster]
GI:665407386 gnl FlyBase 1283 Niemann-Pick type C-1a, isoform F [Drosophila melanogaster]
GI:665407386 gnl FlyBase 1283 Niemann-Pick type C-1a, isoform G [Drosophila melanogaster]
GI:320544872 RefSeq NP_609357.2 1287 Niemann-Pick type C-1a, isoform A [Drosophila melanogaster]
GI:24583258 RefSeq NP_001188769.1 1287 Niemann-Pick type C-1a, isoform B [Drosophila melanogaster]
GI:24583258 RefSeq NP_001188770.1 1287 Niemann-Pick type C-1a, isoform C [Drosophila melanogaster]
GI:320544872 RefSeq NP_001188770.1 1287 Niemann-Pick type C-1a, isoform C [Drosophila melanogaster]
GI:320544872 RefSeq NP_001188771.1 1287 Niemann-Pick type C-1a, isoform D [Drosophila melanogaster]
GI:24583258 RefSeq NP_001188771.1 1287 Niemann-Pick type C-1a, isoform D [Drosophila melanogaster]
GI:665407386 RefSeq NP_001285796.1 1283 Niemann-Pick type C-1a, isoform F [Drosophila melanogaster]
GI:665407386 RefSeq NP_001285797.1 1283 Niemann-Pick type C-1a, isoform G [Drosophila melanogaster]

Related Sequences to LMP009052 proteins

Reference Database Accession Length Protein Name
GI:24583258 EMBL CAB56505.1 1287 NPC1 protein [Drosophila melanogaster]
GI:320544872 EMBL CAB56505.1 1287 NPC1 protein [Drosophila melanogaster]
GI:320544872 GenBank AAQ22446.1 1287 RE56428p [Drosophila melanogaster]
GI:24583258 GenBank AAQ22446.1 1287 RE56428p [Drosophila melanogaster]
GI:665407386 gnl FlyBase 1287 Niemann-Pick type C-1a, isoform B [Drosophila melanogaster]
GI:665407386 gnl FlyBase 1287 Niemann-Pick type C-1a, isoform C [Drosophila melanogaster]
GI:665407386 gnl FlyBase 1287 Niemann-Pick type C-1a, isoform D [Drosophila melanogaster]
GI:320544872 gnl FlyBase 1283 Niemann-Pick type C-1a, isoform F [Drosophila melanogaster]
GI:24583258 gnl FlyBase 1283 Niemann-Pick type C-1a, isoform F [Drosophila melanogaster]
GI:24583258 gnl FlyBase 1283 Niemann-Pick type C-1a, isoform G [Drosophila melanogaster]
GI:320544872 gnl FlyBase 1283 Niemann-Pick type C-1a, isoform G [Drosophila melanogaster]
GI:665407386 RefSeq NP_001188769.1 1287 Niemann-Pick type C-1a, isoform B [Drosophila melanogaster]
GI:665407386 RefSeq NP_001188770.1 1287 Niemann-Pick type C-1a, isoform C [Drosophila melanogaster]
GI:665407386 RefSeq NP_001188771.1 1287 Niemann-Pick type C-1a, isoform D [Drosophila melanogaster]
GI:24583258 RefSeq NP_001285795.1 1283 Niemann-Pick type C-1a, isoform E [Drosophila melanogaster]
GI:320544872 RefSeq NP_001285795.1 1283 Niemann-Pick type C-1a, isoform E [Drosophila melanogaster]
GI:24583258 RefSeq NP_001285796.1 1283 Niemann-Pick type C-1a, isoform F [Drosophila melanogaster]
GI:320544872 RefSeq NP_001285796.1 1283 Niemann-Pick type C-1a, isoform F [Drosophila melanogaster]