Gene/Proteome Database (LMPD)

LMPD ID
LMP008289
Gene ID
179838
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein CAV-2
Gene Symbol
cav-2
Synonyms
CELE_C56A3.7
Alternate Names
Protein CAV-2
Chromosome
V

Proteins

Protein CAV-2, isoform a
Refseq ID NP_001256523
Protein GI 392921543
UniProt ID Q18879
mRNA ID NM_001269594
Length 351
RefSeq Status REVIEWED
MTRQNTSESDNTQRPPIPQYDTVDDIDELTDAMDKEDHHHHHHHHEHHHQHQGIAQYDTVEEVETLETVHHRTSLNQEVPTPQRRSHPQYDNLDDIDDQEYITEVEVKSNRGSTLTTRPHVTIKQDEIEDIGERQVTVIEIASQKGSTKRVAPRKDYAPSIPLPEHPAQQSAPPTQQSRPQTTSHKPPNPEMEFDIGVKNIAPVLIHKMNMDDRDPKDSAQYLNTSFFEVFNEPSEQYHSIACVWTLSFKIFEIVRIYSYKILTLIFGLIIAFLGGILFALFAFLNIWIFRPILILTRMAFAQIVLIWPMFLIYIVRPFFYSVGAIFSTARLHTSRGEQVVEVWEKHIHHV
Protein CAV-2, isoform b
Refseq ID NP_001256525
Protein GI 392921547
UniProt ID Q18879
mRNA ID NM_001269596
Length 319
RefSeq Status REVIEWED
MDKEDHHHHHHHHEHHHQHQGIAQYDTVEEVETLETVHHRTSLNQEVPTPQRRSHPQYDNLDDIDDQEYITEVEVKSNRGSTLTTRPHVTIKQDEIEDIGERQVTVIEIASQKGSTKRVAPRKDYAPSIPLPEHPAQQSAPPTQQSRPQTTSHKPPNPEMEFDIGVKNIAPVLIHKMNMDDRDPKDSAQYLNTSFFEVFNEPSEQYHSIACVWTLSFKIFEIVRIYSYKILTLIFGLIIAFLGGILFALFAFLNIWIFRPILILTRMAFAQIVLIWPMFLIYIVRPFFYSVGAIFSTARLHTSRGEQVVEVWEKHIHHV
Protein CAV-2, isoform c
Refseq ID NP_001256526
Protein GI 392921549
UniProt ID Q18879
mRNA ID NM_001269597
Length 160
RefSeq Status REVIEWED
MEFDIGVKNIAPVLIHKMNMDDRDPKDSAQYLNTSFFEVFNEPSEQYHSIACVWTLSFKIFEIVRIYSYKILTLIFGLIIAFLGGILFALFAFLNIWIFRPILILTRMAFAQIVLIWPMFLIYIVRPFFYSVGAIFSTARLHTSRGEQVVEVWEKHIHHV
Protein CAV-2, isoform d
Refseq ID NP_001256524
Protein GI 392921545
UniProt ID Q18879
mRNA ID NM_001269595
Length 281
RefSeq Status REVIEWED
MTRQNTSESDNTQRPPIPQYDTVDDIDDQEYITEVEVKSNRGSTLTTRPHVTIKQDEIEDIGERQVTVIEIASQKGSTKRVAPRKDYAPSIPLPEHPAQQSAPPTQQSRPQTTSHKPPNPEMEFDIGVKNIAPVLIHKMNMDDRDPKDSAQYLNTSFFEVFNEPSEQYHSIACVWTLSFKIFEIVRIYSYKILTLIFGLIIAFLGGILFALFAFLNIWIFRPILILTRMAFAQIVLIWPMFLIYIVRPFFYSVGAIFSTARLHTSRGEQVVEVWEKHIHHV

Gene Information

Entrez Gene ID
179838
Gene Name
Protein CAV-2
Gene Symbol
cav-2
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016324 IDA:UniProtKB C apical plasma membrane
GO:0005901 TAS:WormBase C caveola
GO:0005319 IMP:UniProtKB F lipid transporter activity
GO:0004871 TAS:WormBase F signal transducer activity
GO:0007166 TAS:WormBase P cell surface receptor signaling pathway
GO:0006869 IMP:GOC P lipid transport
GO:0007567 IMP:UniProtKB P parturition
GO:0046662 IGI:WormBase P regulation of oviposition

KEGG Pathway Links

KEGG Pathway ID Description
cel04144 Endocytosis
ko04144 Endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR001612 Caveolin

UniProt Annotations

Entry Information

Gene Name
Protein CAV-2
Protein Entry
CAV2_CAEEL
UniProt ID
Q18879
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=a; IsoId=Q18879-1; Sequence=Displayed; Name=b; IsoId=Q18879-2; Sequence=VSP_043963; Note=No experimental confirmation available.; Name=c; IsoId=Q18879-3; Sequence=VSP_043962; Note=No experimental confirmation available.; Name=d; IsoId=Q18879-4; Sequence=VSP_043964; Note=No experimental confirmation available.;
Disruption Phenotype Defective in the apical uptake of lipid and protein trafficking. Reduced brood size thought to be due to attenuated nutrient supply. {ECO:0000269|PubMed:19158391}.
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. {ECO:0000269|PubMed:19158391, ECO:0000269|PubMed:19907693}.
Similarity Belongs to the caveolin family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000269|PubMed:19158391}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
Subunit Homooligomer. {ECO:0000250}.
Tissue Specificity Expressed in intracellular bodies in intestinal cells. {ECO:0000269|PubMed:19158391}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008289 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
392921543 RefSeq NP_001256523 351 Protein CAV-2, isoform a
392921547 RefSeq NP_001256525 319 Protein CAV-2, isoform b
392921549 RefSeq NP_001256526 160 Protein CAV-2, isoform c
392921545 RefSeq NP_001256524 281 Protein CAV-2, isoform d

Identical Sequences to LMP008289 proteins

Reference Database Accession Length Protein Name
GI:392921543 EMBL CAB01139.1 351 Protein CAV-2, isoform a [Caenorhabditis elegans]
GI:392921547 EMBL CBW48350.1 319 Protein CAV-2, isoform b [Caenorhabditis elegans]
GI:392921549 EMBL CBW48351.1 160 Protein CAV-2, isoform c [Caenorhabditis elegans]
GI:392921545 EMBL CCD31049.1 281 Protein CAV-2, isoform d [Caenorhabditis elegans]
GI:392921543 SwissProt Q18879.3 351 RecName: Full=Caveolin-2 [Caenorhabditis elegans]

Related Sequences to LMP008289 proteins

Reference Database Accession Length Protein Name
GI:392921547 EMBL CAB01139.1 351 Protein CAV-2, isoform a [Caenorhabditis elegans]
GI:392921545 EMBL CAB01139.1 351 Protein CAV-2, isoform a [Caenorhabditis elegans]
GI:392921549 EMBL CAB01139.1 351 Protein CAV-2, isoform a [Caenorhabditis elegans]
GI:392921543 EMBL CBW48350.1 319 Protein CAV-2, isoform b [Caenorhabditis elegans]
GI:392921549 EMBL CBW48350.1 319 Protein CAV-2, isoform b [Caenorhabditis elegans]
GI:392921545 EMBL CBW48350.1 319 Protein CAV-2, isoform b [Caenorhabditis elegans]
GI:392921543 EMBL CCD31049.1 281 Protein CAV-2, isoform d [Caenorhabditis elegans]
GI:392921547 EMBL CCD31049.1 281 Protein CAV-2, isoform d [Caenorhabditis elegans]
GI:392921543 GenBank AAB48299.1 351 caveolin-2 [Caenorhabditis elegans]
GI:392921545 GenBank AAB48299.1 351 caveolin-2 [Caenorhabditis elegans]
GI:392921547 GenBank AAB48299.1 351 caveolin-2 [Caenorhabditis elegans]
GI:392921549 GenBank AAB48299.1 351 caveolin-2 [Caenorhabditis elegans]
GI:392921543 RefSeq XP_003114363.1 282 CRE-CAV-2 protein [Caenorhabditis remanei]
GI:392921547 RefSeq NP_001256523.1 351 Protein CAV-2, isoform a [Caenorhabditis elegans]
GI:392921549 RefSeq NP_001256523.1 351 Protein CAV-2, isoform a [Caenorhabditis elegans]
GI:392921545 RefSeq NP_001256523.1 351 Protein CAV-2, isoform a [Caenorhabditis elegans]
GI:392921543 RefSeq NP_001256524.1 281 Protein CAV-2, isoform d [Caenorhabditis elegans]
GI:392921547 RefSeq NP_001256524.1 281 Protein CAV-2, isoform d [Caenorhabditis elegans]
GI:392921543 RefSeq NP_001256525.1 319 Protein CAV-2, isoform b [Caenorhabditis elegans]
GI:392921549 RefSeq NP_001256525.1 319 Protein CAV-2, isoform b [Caenorhabditis elegans]
GI:392921545 RefSeq NP_001256525.1 319 Protein CAV-2, isoform b [Caenorhabditis elegans]
GI:392921549 SwissProt Q18879.3 351 RecName: Full=Caveolin-2 [Caenorhabditis elegans]
GI:392921545 SwissProt Q18879.3 351 RecName: Full=Caveolin-2 [Caenorhabditis elegans]
GI:392921547 SwissProt Q18879.3 351 RecName: Full=Caveolin-2 [Caenorhabditis elegans]