Gene/Proteome Database (LMPD)

LMPD ID
LMP008161
Gene ID
175358
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein H14E04.1
Gene Symbol
H14E04.1
Synonyms
CELE_H14E04.1
Alternate Names
Protein H14E04.1
Chromosome
III
EC Number
2.1.1.-

Proteins

Protein H14E04.1
Refseq ID NP_497549
Protein GI 25143945
UniProt ID Q9TYP1
mRNA ID NM_065148
Length 334
RefSeq Status REVIEWED
MSINMNANFLKLLTHFRRHDLTNFKSEHDTLYEKALETGDHLEVTSHYYSVMSTVIDEYFGGNFHFVPPKFEGQKLEEALKSLHCHIAEKLELSENVHCLDIGCGIGGVMLDIADFGAKLTGVTIAPNEAEIGNEKFANMGISDRCKIVAADCQKMPFEDSTFDVAYAIYSLKYIPNLDKVMKEIQRVLKPGGKFIVYDLIKTNDYDKDNKEHYKTLHHLEYACGMPSLHTQSEVEAAAEKWEMPVVERENLEETYGNRAFHYCFSASPMFMWLVSSPVIDHTIRMAEILRILPAGFKQFNRTFLCGTVNSIVGGGRMGILSGADILLFEKKKI

Gene Information

Entrez Gene ID
175358
Gene Name
Protein H14E04.1
Gene Symbol
H14E04.1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008757 IMP:WormBase F S-adenosylmethionine-dependent methyltransferase activity
GO:0008203 IEA:UniProtKB-KW P cholesterol metabolic process
GO:0043414 IMP:WormBase P macromolecule methylation
GO:0061065 IMP:WormBase P regulation of dauer larval development

Domain Information

InterPro Annotations

Accession Description
IPR013216 Methyltransferase type 11
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase

UniProt Annotations

Entry Information

Gene Name
Protein H14E04.1
Protein Entry
STRM1_CAEEL
UniProt ID
Q9TYP1
Species
C. elegans

Comments

Comment Type Description
Function Catalyzes the methyl transfer from S-adenosyl-methionine to the C-4 of cholesterol and other sterols. May irreversibly shunt sterols away from dafachronic acid production. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. {ECO:0000269|PubMed:19531354}.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. {ECO:0000255|PROSITE-ProRule:PRU01022}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008161 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25143945 RefSeq NP_497549 334 Protein H14E04.1

Identical Sequences to LMP008161 proteins

Reference Database Accession Length Protein Name
GI:25143945 EMBL CCD72180.1 334 Protein H14E04.1 [Caenorhabditis elegans]
GI:25143945 SwissProt Q9TYP1.2 334 RecName: Full=Sterol 4-C-methyltransferase strm-1 [Caenorhabditis elegans]

Related Sequences to LMP008161 proteins

Reference Database Accession Length Protein Name
GI:25143945 EMBL CAP33846.2 338 Protein CBG15658 [Caenorhabditis briggsae]
GI:25143945 GenBank ABZ31716.1 366 Sequence 5654 from patent US 7314974
GI:25143945 GenBank EGT42750.1 334 hypothetical protein CAEBREN_24369 [Caenorhabditis brenneri]
GI:25143945 GenBank EGT44642.1 334 hypothetical protein CAEBREN_11448 [Caenorhabditis brenneri]
GI:25143945 RefSeq XP_002640783.1 331 Hypothetical protein CBG15658, partial [Caenorhabditis briggsae]
GI:25143945 RefSeq XP_003091780.1 367 hypothetical protein CRE_08584 [Caenorhabditis remanei]