Gene/Proteome Database (LMPD)

LMPD ID
LMP008034
Gene ID
180719
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein NCR-1
Gene Symbol
ncr-1
Synonyms
CELE_F02E8.6
Chromosome
X

Proteins

Protein NCR-1
Refseq ID NP_508771
Protein GI 17569119
UniProt ID Q19127
mRNA ID NM_076370
Length 1383
RefSeq Status REVIEWED
MKQLLIFCLLFGSIFHHGDAGCIMRGLCQKHTENAYGPCVTNDTNVEPTAFDKTHPAYEKMVEFCPHLLTGDNKLCCTPSQAEGLTKQIAQARHILGRCPSCFDNFAKLWCEFTCSPNQQDFVSISEMKPIEKKEGFTPEYQPAEAYVNTVEYRLSTDFAEGMFSSCKDVTFGGQPALRVMCTSTPCTLTNWLEFIGTQNLDLNIPIHTKFLLYDPIKTPPSDRSTYMNVNFTGCDKSARVGWPACSTSECNKEEYANLIDLDDGKTSGQTCNVHGIACLNIFVMLAFIGSLAVLLCVGFVFTSYDEDYTNLRQTQSGEESPKRNRIKRTGAWIHNFMENNARDIGMMAGRNPKSHFFIGCAVLIFCLPGMIYHKESTNVVDMWSSPRSRARQEEMVFNANFGRPQRYQQIMLLSHRDFQSSGKLYGPVFHKDIFEELFDILNAIKNISTQDSDGRTITLDDVCYRPMGPGYDCLIMSPTNYFQGNKEHLDMKSNKEETVSEDDDAFDYFSSEATTDEWMNHMAACIDQPMSQKTKSGLSCMGTYGGPSAPNMVFGKNSTNHQAANSIMMTILVTQRTEPEIQKAELWEKEFLKFCKEYREKSPKVIFSFMAERSITDEIENDAKDEIVTVVIALAFLIGYVTFSLGRYFVCENQLWSILVHSRICLGMLSVIINLLSSFCSWGIFSMFGIHPVKNALVVQFFVVTLLGVCRTFMVVKYYAQQRVSMPYMSPDQCPEIVGMVMAGTMPAMFSSSLGCAFSFFIGGFTDLPAIRTFCLYAGLAVLIDVVLHCTIFLALFVWDTQRELNGKPEFFFPYQIKDLLGAYLIGRQRATDTFMTQFFHFQVAPFLMHRMTRIITGIIFIASFITTVILSSKISVGFDQSMAFTEKSYISTHFRYLDKFFDVGPPVFFTVDGELDWHRPDVQNKFCTFPGCSDTSFGNIMNYAVGHTEQTYLSGEMYNWIDNYLEWISRKSPCCKVYVHDPNTFCSTNRNKSALDDKACRTCMDFDYVANSYPKSSIMYHRPSIEVFYRHLRHFLEDTPNSECVFGGRASFKDAISFTSRGRIQASQFMTFHKKLSISNSSDFIKAMDTARMVSRRLERSIDDTAHVFAYSKIFPFYEQYSTIMPILTTQLFITVVGVFGIICVTLGIDVKGAACAVICQVSNYFHIVAFMYIFNIPVNALSATNLVMSSGILIEFSVNVLKGYACSLRQRAKDRAESTVGSIGPIILSGPVVTMAGSTMFLSGAHLQIITVYFFKLFLITIVSSAVHALIILPILLAFGGSRGHGSSETSTNDNDEQHDACVLSPTAESHISNVEEGILNRPSLLDASHILDPLLKAEGGIDKAIDIITIDRSYPSTPSSLPCTSRMPRAHIEPDLRSL

Gene Information

Entrez Gene ID
180719
Gene Name
Protein NCR-1
Gene Symbol
ncr-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005770 ISS:WormBase C late endosome
GO:0005764 ISS:WormBase C lysosome
GO:0008158 IEA:InterPro F hedgehog receptor activity
GO:0042632 IMP:WormBase P cholesterol homeostasis
GO:0030301 IMP:WormBase P cholesterol transport
GO:0040024 IGI:WormBase P dauer larval development
GO:0040010 IMP:WormBase P positive regulation of growth rate
GO:0046662 IMP:WormBase P regulation of oviposition

Domain Information

InterPro Annotations

Accession Description
IPR003392 Patched
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
Protein NCR-1
Protein Entry
Q19127_CAEEL
UniProt ID
Q19127
Species
C. elegans

Comments

Comment Type Description
Disruption Phenotype Both ncr-1 single mutant and ncr-1 and ncr-2 double mutants exhibit slow embryonic and larval development, and hyperactive egg-laying behavior (egg-laying constitutive (egl-c) phenotype). Ncr-1 and ncr-2 double mutants inappropriately and transiently form dauer larvae under favorable conditions (dauer- constitutive (daf-c) phenotype).
Function Involved in the uptake or utilization of cholesterol. Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons.
Similarity Belongs to the patched family.
Similarity Contains 1 SSD (sterol-sensing) domain.
Subcellular Location Membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP008034 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17569119 RefSeq NP_508771 1383 Protein NCR-1

Identical Sequences to LMP008034 proteins

Reference Database Accession Length Protein Name
GI:17569119 EMBL CCD83387.1 1383 Protein NCR-1 [Caenorhabditis elegans]
GI:17569119 SwissProt Q19127.2 1383 RecName: Full=Niemann-Pick C1 protein homolog 1; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008034 proteins

Reference Database Accession Length Protein Name
GI:17569119 EMBL CAP32985.2 1431 Protein CBR-NCR-1 [Caenorhabditis briggsae]
GI:17569119 GenBank ABH83293.1 1296 Sequence 9 from patent US 7045675
GI:17569119 GenBank EFO82715.1 1382 CRE-NCR-1 protein [Caenorhabditis remanei]
GI:17569119 GenBank EGT30023.1 1381 CBN-NCR-1 protein [Caenorhabditis brenneri]
GI:17569119 RefSeq XP_002644546.1 1382 C. briggsae CBR-NCR-1 protein [Caenorhabditis briggsae]
GI:17569119 RefSeq XP_003118117.1 1382 CRE-NCR-1 protein [Caenorhabditis remanei]