Gene/Proteome Database (LMPD)

LMPD ID
LMP007949
Gene ID
174279
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein ZK669.4
Gene Symbol
ZK669.4
Synonyms
CELE_ZK669.4
Alternate Names
Protein ZK669.4
Chromosome
II
EC Number
2.3.1.168

Proteins

Protein ZK669.4
Refseq ID NP_495670
Protein GI 17537937
UniProt ID Q23571
mRNA ID NM_063269
Length 448
RefSeq Status REVIEWED
MMAARLLGTSSRIFKLNKHLHTSKVAFMPVVQFKLSDIGEGIAEVQVKEWYVKEGDTISQFDKVCEVQSDKAAVTISCRYDGIVKKLYHEVDGMARVGQALIDVEIEGNVEEPEQPKKEAASSSPEAPKSSAPKAPESAHSEGKVLATPAVRRIAIENKIKLAEVRGTGKDGRVLKEDVLKFLGQVPADHTSGSTNIRTTHQAPQPSSKSYEPLKEDVAVPIRGYTRAMVKTMTEALKIPHFGYNDEINVDSLVKYRAELKEFAKERHIKLSYMPFFIKAASLALLEYPSLNSTTDEKMENVIHKASHNICLAMDTPGGLVVPNIKNCEQRSIFEIAQELNRLLEAGKKQQIKREDLIDGTFSLSNIGNIGGTYASPVVFPPQVAIGAIGKIEKLPRFDKHDNVIPVNIMKVSWCADHRVVDGATMARFSNRWKFYLEHPSAMLAQLK

Gene Information

Entrez Gene ID
174279
Gene Name
Protein ZK669.4
Gene Symbol
ZK669.4
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0043754 IEA:UniProtKB-EC F dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
cel01100 Metabolic pathways
cel00280 Valine, leucine and isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5652523 Branched-chain amino acid catabolism

Domain Information

InterPro Annotations

Accession Description
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR000089 Biotin/lipoyl attachment
IPR023213 Chloramphenicol acetyltransferase-like domain
IPR004167 E3-binding domain
IPR015761 Lipoamide Acyltransferase
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
Protein ZK669.4
Protein Entry
ODB2_CAEEL
UniProt ID
Q23571
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity 2-methylpropanoyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-(2- methylpropanoyl)dihydrolipoyl)lysine.
Cofactor Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence={ECO:0000250}; Note=Binds 1 lipoyl cofactor covalently. {ECO:0000250};
Function The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component (By similarity). {ECO:0000250}.
Similarity Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
Similarity Contains 1 E3-binding domain. {ECO:0000305}.
Similarity Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007949 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17537937 RefSeq NP_495670 448 Protein ZK669.4

Identical Sequences to LMP007949 proteins

Reference Database Accession Length Protein Name
GI:17537937 EMBL CAA85465.1 448 Protein ZK669.4 [Caenorhabditis elegans]
GI:17537937 GenBank ABZ31527.1 448 Sequence 5465 from patent US 7314974
GI:17537937 SwissProt Q23571.1 448 RecName: Full=Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; AltName: Full=Branched-chain alpha-keto acid dehydrogenase complex component E2; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007949 proteins

Reference Database Accession Length Protein Name
GI:17537937 EMBL CAP23399.2 482 Protein CBG03281 [Caenorhabditis briggsae]
GI:17537937 EMBL CDJ84036.1 461 Biotin lipoyl attachment and E3 binding and 2-oxoacid dehydrogenase acyltransferase domain containing protein [Haemonchus contortus]
GI:17537937 GenBank EFO86267.1 447 hypothetical protein CRE_01908 [Caenorhabditis remanei]
GI:17537937 GenBank EGT43017.1 451 hypothetical protein CAEBREN_25669 [Caenorhabditis brenneri]
GI:17537937 RefSeq XP_002631425.1 448 Hypothetical protein CBG03281 [Caenorhabditis briggsae]
GI:17537937 RefSeq XP_003117401.1 447 hypothetical protein CRE_01908 [Caenorhabditis remanei]