Gene/Proteome Database (LMPD)

LMPD ID
LMP007891
Gene ID
181001
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein ACL-12
Gene Symbol
acl-12
Synonyms
CELE_C01C10.3
Alternate Names
Protein ACL-12
Chromosome
X
EC Number
2.3.1.51

Proteins

Protein ACL-12
Refseq ID NP_509260
Protein GI 17550020
UniProt ID Q11087
mRNA ID NM_076859
Length 391
RefSeq Status REVIEWED
MLKSGLMDTDDQKVGVRVANIDMSERTDNVHLIEIRRIISLVGAAYFFFMTAWVVPVACVITVSLLFPLMLFSTPLFNYLEHKLCAMVNAHWNAVSVFVGATVTEYGTNLAGYAEEKCLLLANHLGLLDHFVLMQSLNGKGSIRSRWMWVIYNIWKYTPLGVMWTSHGNFFVNGGVSKRDSVLSSFRDHLKNSFYKYDYGWVIMYPEGSRLYLVKNSGRTFAEKNGLKPLDNCVYPRTGAAHAVLDVLGPTDDSLSMSKCGKGEPIKYIIDATIGYRKGAVPDICDVMMGDWESVEASQFAVHYDVIPVKPEWSDENLLKEFLYERYIIKDKLLAEFYKTGHFPGDKTKVIPNNYEMMFAQVFWGCLYYAHYVYWLRPLIVHSWTSFLSIF

Gene Information

Entrez Gene ID
181001
Gene Name
Protein ACL-12
Gene Symbol
acl-12
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003841 IEA:UniProtKB-EC F 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016024 IEA:UniProtKB-UniPathway P CDP-diacylglycerol biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5653398 Acyl chain remodelling of PG
5652685 Glycerophospholipid biosynthesis
5652530 Metabolism of lipids and lipoproteins
5652686 Phospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
Protein ACL-12
Protein Entry
PLC12_CAEEL
UniProt ID
Q11087
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
Function Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000250}.
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Similarity Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007891 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17550020 RefSeq NP_509260 391 Protein ACL-12

Identical Sequences to LMP007891 proteins

Reference Database Accession Length Protein Name
GI:17550020 EMBL CCD62384.1 391 Protein ACL-12 [Caenorhabditis elegans]
GI:17550020 SwissProt Q11087.1 391 RecName: Full=Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-12; Short=1-AGP acyltransferase; Short=1-AGPAT; AltName: Full=Lysophosphatidic acid acyltransferase; Short=LPAAT [Caenorhabditis elegans]

Related Sequences to LMP007891 proteins

Reference Database Accession Length Protein Name
GI:17550020 EMBL CAP34600.1 391 Protein CBR-ACL-12 [Caenorhabditis briggsae]
GI:17550020 GenBank EFO82759.1 407 CRE-ACL-12 protein [Caenorhabditis remanei]
GI:17550020 GenBank ADY45619.1 398 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-12 [Ascaris suum]
GI:17550020 GenBank EGT33186.1 392 CBN-ACL-12 protein [Caenorhabditis brenneri]
GI:17550020 RefSeq XP_002645042.1 391 C. briggsae CBR-ACL-12 protein [Caenorhabditis briggsae]
GI:17550020 RefSeq XP_003118161.1 407 CRE-ACL-12 protein [Caenorhabditis remanei]