Gene/Proteome Database (LMPD)

LMPD ID
LMP007879
Gene ID
179438
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein B0024.13
Gene Symbol
B0024.13
Synonyms
CELE_B0024.13
Alternate Names
Protein B0024.13
Chromosome
V
EC Number
1.3.1.94

Proteins

Protein B0024.13
Refseq ID NP_001256209
Protein GI 392920298
UniProt ID Q17428
mRNA ID NM_001269280
Length 309
RefSeq Status REVIEWED
MLDRLWEVRQALPLYLLVSTLGLAISCCFTLICPHVCRLIPALTTYGKAADQQEDNSLVEKISVPKKWFKHFYAIGLLTLFICLHTVHSLIYNPNYLHPVVLKILATLTRSYSIPPITPSTSILALLLISLHVARRLYETIFVSVYSDSRMNLFHYAVGIVHYIILPISIMCETQGVASKLPQLHVSIDDISLTQWAGAVLFWICNWKQHQLAEQIANTRKGPRGLIRNYAYGICFGGWFNLVSCPHFLFEICIYLSLFLVIPDAYVYRFIIMFVCINQTFAALITHSWYHKTFPKYPKSRKALIPYVL

Gene Information

Entrez Gene ID
179438
Gene Name
Protein B0024.13
Gene Symbol
B0024.13
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016627 IEA:InterPro F oxidoreductase activity, acting on the CH-CH group of donors
GO:0019348 ISS:UniProtKB P dolichol metabolic process
GO:0006488 ISS:UniProtKB P dolichol-linked oligosaccharide biosynthetic process
GO:0016095 ISS:UniProtKB P polyprenol catabolic process
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

REACTOME Pathway Links

REACTOME Pathway ID Description
5652986 Androgen biosynthesis
5652987 Metabolism of steroid hormones and vitamin D
5652979 Synthesis of Dolichyl-phosphate
5652980 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal

UniProt Annotations

Entry Information

Gene Name
Protein B0024.13
Protein Entry
PORED_CAEEL
UniProt ID
Q17428
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Ditrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH.
Function Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). {ECO:0000250}.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007879 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
392920298 RefSeq NP_001256209 309 Protein B0024.13

Identical Sequences to LMP007879 proteins

Reference Database Accession Length Protein Name
GI:392920298 EMBL CAA94885.2 309 Protein B0024.13 [Caenorhabditis elegans]
GI:392920298 SwissProt Q17428.2 309 RecName: Full=Polyprenol reductase [Caenorhabditis elegans]

Related Sequences to LMP007879 proteins

Reference Database Accession Length Protein Name
GI:392920298 EMBL CAP29024.1 309 Protein CBG09584 [Caenorhabditis briggsae]
GI:392920298 GenBank EFP11299.1 325 hypothetical protein CRE_30932 [Caenorhabditis remanei]
GI:392920298 GenBank EGT55526.1 309 hypothetical protein CAEBREN_20981 [Caenorhabditis brenneri]
GI:392920298 RefSeq XP_002637085.1 309 Hypothetical protein CBG09584 [Caenorhabditis briggsae]
GI:392920298 RefSeq XP_003112778.1 325 hypothetical protein CRE_30932 [Caenorhabditis remanei]
GI:392920298 SwissProt A8X8R3.1 309 RecName: Full=Polyprenol reductase [Caenorhabditis briggsae]