Gene/Proteome Database (LMPD)

LMPD ID
LMP007867
Gene ID
177235
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein OGDH-1
Gene Symbol
ogdh-1
Synonyms
CELE_T22B11.5
Alternate Names
Protein OGDH-1
Chromosome
IV
EC Number
1.2.4.2

Proteins

Protein OGDH-1
Refseq ID NP_500617
Protein GI 17542494
UniProt ID O61199
mRNA ID NM_068216
Length 1029
RefSeq Status REVIEWED
MHRASLICRLASPSRINAIRNASSGKSHISASTLVQHRNQSVAAAVKHEPFLNGSSSIYIEQMYEAWLQDPSSVHTSWDAYFRNVEAGAGPGQAFQAPPATAYAGALGVSPAAAQVTTSSAPATRLDTNASVQSISDHLKIQLLIRSYQTRGHNIADLDPLGINSADLDDTIPPELELSFYGLGERDLDREFLLPPTTFISEKKSLTLREILQRLKDIYCTSTGVEYMHLNNLEQQDWIRRRFEAPRVTELSHDQKKVLFKRLIRSTKFEEFLAKKWPSEKRFGLEGCEVLIPAMKQVIDSSSTLGVDSFVIGMPHRGRLNVLANVCRQPLATILSQFSTLEPADEGSGDVKYHLGVCIERLNRQSQKNVKIAVVANPSHLEAVDPVVMGKVRAEAFYAGDEKCDRTMAILLHGDAAFAGQGVVLETFNLDDLPSYTTHGAIHIVVNNQIGFTTDPRSSRSSPYCTDVGRVVGCPIFHVNVDDPEAVMHVCNVAADWRKTFKKDVIVDLVCYRRHGHNELDEPMFTQPLMYQRIKQTKTALEKYQEKILNEGVANEQYVKEELTKYGSILEDAYENAQKVTYVRNRDWLDSPWDDFFKKRDPLKLPSTGIEQENIEQIIGKFSQYPEGFNLHRGLERTLKGRQQMLKDNSLDWACGEALAFGSLLKEGIHVRLSGQDVQRGTFSHRHHVLHDQKVDQKIYNPLNDLSEGQGEYTVCNSSLSEYAVLGFELGYSMVDPNSLVIWEAQFGDFSNTAQCIIDQFISSGQSKWIRQSGLVMLLPHGYEGMGPEHSSARPERFLQMCNEDDEIDLEKIAFEGTFEAQQLHDTNWIVANCTTPANIYHLLRRQVTMPFRKPAVVFSPKSLLRHPMARSPVEDFQSGSNFQRVIPETGAPSQNPPDVKRVVFCTGKVYYDMVAARKHVGKENDVALVRVEQLSPFPYDLVQQECRKYQGAEILWAQEEHKNMGAWSFVQPRINSLLSIDGRATKYAGRLPSSSPATGNKFTHMQEQKEMMSKVFGVPKSKLEGFKA

Gene Information

Entrez Gene ID
177235
Gene Name
Protein OGDH-1
Gene Symbol
ogdh-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031966 ISS:UniProtKB C mitochondrial membrane
GO:0005739 IDA:WormBase C mitochondrion
GO:0004591 ISS:UniProtKB F oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0030976 IEA:InterPro F thiamine pyrophosphate binding
GO:0006091 ISS:UniProtKB P generation of precursor metabolites and energy
GO:0006096 IEA:UniProtKB-KW P glycolytic process
GO:0006099 IEA:InterPro P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
cel01200 Carbon metabolism
cel00020 Citrate cycle (TCA cycle)
cel_M00009 Citrate cycle (TCA cycle, Krebs cycle)
cel_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate

Domain Information

InterPro Annotations

Accession Description
IPR011603 2-oxoglutarate dehydrogenase E1 component
IPR001017 Dehydrogenase, E1 component
IPR029061 Thiamin diphosphate-binding fold
IPR005475 Transketolase-like, pyrimidine-binding domain

UniProt Annotations

Entry Information

Gene Name
Protein OGDH-1
Protein Entry
ODO1_CAEEL
UniProt ID
O61199
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2). {ECO:0000250|UniProtKB:Q02218}.
Cofactor Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250|UniProtKB:Q02218};
Function The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250|UniProtKB:Q02218}.
Similarity Belongs to the alpha-ketoglutarate dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007867 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17542494 RefSeq NP_500617 1029 Protein OGDH-1

Identical Sequences to LMP007867 proteins

Reference Database Accession Length Protein Name
GI:17542494 EMBL CCD70240.1 1029 Protein OGDH-1, isoform a [Caenorhabditis elegans]
GI:17542494 SwissProt O61199.2 1029 RecName: Full=2-oxoglutarate dehydrogenase, mitochondrial; AltName: Full=2-oxoglutarate dehydrogenase complex component E1; Short=OGDC-E1; AltName: Full=Alpha-ketoglutarate dehydrogenase; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007867 proteins

Reference Database Accession Length Protein Name
GI:17542494 EMBL CAP22897.1 1027 Protein CBR-OGDH-1 [Caenorhabditis briggsae]
GI:17542494 GenBank ABZ32040.1 1038 Sequence 5978 from patent US 7314974
GI:17542494 GenBank EFO93138.1 1031 hypothetical protein CRE_10246 [Caenorhabditis remanei]
GI:17542494 RefSeq XP_002634170.1 1027 Hypothetical protein CBG01737 [Caenorhabditis briggsae]
GI:17542494 RefSeq XP_003108338.1 1031 hypothetical protein CRE_10246 [Caenorhabditis remanei]
GI:17542494 SwissProt Q623T0.1 1027 RecName: Full=2-oxoglutarate dehydrogenase, mitochondrial; AltName: Full=2-oxoglutarate dehydrogenase complex component E1; Short=OGDC-E1; AltName: Full=Alpha-ketoglutarate dehydrogenase; Flags: Precursor [Caenorhabditis briggsae]