Gene/Proteome Database (LMPD)

LMPD ID
LMP007862
Gene ID
176165
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein NCR-2
Gene Symbol
ncr-2
Synonyms
CELE_F09G8.4
Alternate Names
Protein NCR-2
Chromosome
III

Proteins

Protein NCR-2
Refseq ID NP_498813
Protein GI 17554358
UniProt ID P34389
mRNA ID NM_066412
Length 1274
RefSeq Status REVIEWED
MRQGGGGGERMVSVLFLLLIHLALCQAKCVMTECDGEEDSNHPPCKTNKSTYLPITVTRSLNPTYMARFEKYCSYLVQEEDKAQVCCTELQLKGMTDRISNAATILGSCPSCFDNFAKLWCQFTCSPDQSKFMKVMETTGPKNVVVKMEFKVNRDFVEGLYESCRHTWFANGLALRLMSLGGKVSFENFYGFMGTKNLAQSIPINTEFQFSRMKNAMNIPTTPCHKSAGPKVPACGAIDCPTNAHQLVDISKVEHLGTKVFHPHFPDFEWLLKICGCLALTVLLVFILKYSCHRRSAPNGEDGCYVDLGKGNLEVQFEGLCARYANAVIKHPLIFVSLGLIVAAACCSGNFKFHSLTHSVDQVSAADGETRRNEKKFIHSFGPNHRIEQIFINLPPTTKSMFNMPLFEEMFQLVGNIQNLTACYGNSSVKLDDICYKPIGKNHGCAIMSPTNYFQNKWTNFENAGPPTIDDEIFDDQHWEHLKYCIRNPLTVSTYSEMSCFGEFSGPIDPILVFGGSNESIKGAEMYYTARTIMITVLIRGPEDQAIAWETAFLNMMSRYEMKHANFTFMTETSVAEEIHTAVETDKIVSVIACAAVLIWVITMLGINHWPESSILSALVHHKLLISISAVMISVISVWCSIGMFSLFGVHATDNAIVVLFFVITCLGINRIFVIIRTFQANGHCYGLPNISYREMNHRISNVMRRSIPIVLTNSLICSTCLFLAGGVLPYVSVSMPAVEVFARHAGLAILMDTAFYLLVMLPLFQYDARREMSGKCEIWPWYELSNESKINLCMEAVDGNLRSPVDWFKLAIAPLLLKKICRIWIATFFFVSLIIACYCTLCLEFGFNQVMAFSETSYLTKHFQNMNENLNIGPPLWFVVEGDVKWHDPKMQNKFCTLAGCDDNSMGNKIRSLAYAENYKGNYLHGDVNIWLDSYLQFMHPRGSCCKMDGKQFCDPSNATHCSSCSSSSVASLTTTEYEFYRNLHHFLETPPSIQCAHGGMALAKPAINLTRNGKIQSAYFSTFFKKLNLSDSIQLYDAWRFAKYLADDIERELEIPGVKVYVYSTFFPYYEQYLTLSTTVYTLVVLVLFVAFVTISLFLRVNLAGSLVTVFVLLSSYLHLMEWMYLLGITVNVVSVINMAMSLGIAVEFFGQMLHGFYNSKKPKREERAFAALVSNGSTTLSGIFPAIMITAGCLSFADSRVLITYFCNQLVGIGLVCAVHGVVYMPTLLAIFGSDFYQNVSSEEESTDEAELQDTPPSTTSSTSSTSETSV

Gene Information

Entrez Gene ID
176165
Gene Name
Protein NCR-2
Gene Symbol
ncr-2
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008158 IEA:InterPro F hedgehog receptor activity
GO:0042632 IGI:WormBase P cholesterol homeostasis
GO:0030301 IGI:WormBase P cholesterol transport
GO:0040024 IGI:WormBase P dauer larval development
GO:0040025 IGI:WormBase P vulval development

REACTOME Pathway Links

REACTOME Pathway ID Description
5652872 Lipid digestion, mobilization, and transport
5652491 Metabolism
5652530 Metabolism of lipids and lipoproteins
5653111 Trafficking of dietary sterols

Domain Information

InterPro Annotations

Accession Description
IPR003392 Patched
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
Protein NCR-2
Protein Entry
NPC2_CAEEL
UniProt ID
P34389
Species
C. elegans

Comments

Comment Type Description
Disruption Phenotype Both ncr-1 single mutant and ncr-1 and ncr-2 double mutants exhibit slow embryonic and larval development, and hyperactive egg-laying behavior (egg-laying constitutive (egl-c) phenotype). Ncr-1 and ncr-2 double mutants inappropriately and transiently form dauer larvae under favorable conditions (dauer- constitutive (daf-c) phenotype). {ECO:0000269|PubMed:10801441}.
Function Involved in the uptake or utilization of cholesterol. Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. {ECO:0000269|PubMed:10801441}.
Similarity Belongs to the patched family. {ECO:0000305}.
Similarity Contains 1 SSD (sterol-sensing) domain. {ECO:0000255|PROSITE-ProRule:PRU00199}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007862 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17554358 RefSeq NP_498813 1274 Protein NCR-2

Identical Sequences to LMP007862 proteins

Reference Database Accession Length Protein Name
GI:17554358 EMBL CCD62644.1 1274 Protein NCR-2 [Caenorhabditis elegans]
GI:17554358 SwissProt P34389.2 1274 RecName: Full=Niemann-Pick C1 protein homolog 2; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007862 proteins

Reference Database Accession Length Protein Name
GI:17554358 EMBL CAP34565.3 1222 Protein CBR-NCR-2, partial [Caenorhabditis briggsae]
GI:17554358 GenBank EFP09632.1 963 CRE-NCR-2 protein [Caenorhabditis remanei]
GI:17554358 GenBank EGT30023.1 1381 CBN-NCR-1 protein [Caenorhabditis brenneri]
GI:17554358 GenBank EGT53247.1 1190 CBN-NCR-2 protein [Caenorhabditis brenneri]
GI:17554358 RefSeq XP_002641948.1 1222 C. briggsae CBR-NCR-2 protein, partial [Caenorhabditis briggsae]
GI:17554358 RefSeq XP_003113378.1 963 CRE-NCR-2 protein [Caenorhabditis remanei]