Gene/Proteome Database (LMPD)

LMPD ID
LMP007805
Gene ID
178291
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein FAT-1
Gene Symbol
fat-1
Synonyms
CELE_Y67H2A.8
Alternate Names
Protein FAT-1
Chromosome
IV
EC Number
1.14.19.-

Proteins

Protein FAT-1
Refseq ID NP_001023560
Protein GI 71999459
UniProt ID Q9NEQ0
mRNA ID NM_001028389
Length 402
RefSeq Status REVIEWED
MVAHSSEGLSATAPVTGGDVLVDARASLEEKEAPRDVNANTKQATTEEPRIQLPTVDAFRRAIPAHCFERDLVKSIRYLVQDFAALTILYFALPAFEYFGLFGYLVWNIFMGVFGFALFVVGHDCLHGSFSDNQNLNDFIGHIAFSPLFSPYFPWQKSHKLHHAFTNHIDKDHGHVWIQDKDWEAMPSWKRWFNPIPFSGWLKWFPVYTLFGFCDGSHFWPYSSLFVRNSERVQCVISGICCCVCAYIALTIAGSYSNWFWYYWVPLSFFGLMLVIVTYLQHVDDVAEVYEADEWSFVRGQTQTIDRYYGLGLDTTMHHITDGHVAHHFFNKIPHYHLIEATEGVKKVLEPLSDTQYGYKSQVNYDFFARFLWFNYKLDYLVHKTAGIMQFRTTLEEKAKAK

Gene Information

Entrez Gene ID
178291
Gene Name
Protein FAT-1
Gene Symbol
fat-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0042389 IMP:WormBase F omega-3 fatty acid desaturase activity
GO:0006636 IMP:WormBase P unsaturated fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
cel01040 Biosynthesis of unsaturated fatty acids
ko01040 Biosynthesis of unsaturated fatty acids
cel01212 Fatty acid metabolism
ko01212 Fatty acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1

UniProt Annotations

Entry Information

Gene Name
Protein FAT-1
Protein Entry
FAT1_CAEEL
UniProt ID
Q9NEQ0
Species
C. elegans

Comments

Comment Type Description
Function Omega-3 fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linolenic acid (18:2n- 6), dihomo-gamma-linoleic acid (DHGLA) (20:3n-6), and arachidonic acid (20:4n-6), to generate gamma linolenic acid (18:3n-3), eicosatetraenoic acid (20:4n-3) and eicosapentaenoic acid (20:5n- 3) respectively. Although the enzyme has been suggested to act on glycerolipids, the precise nature of the fatty acid substrate is unknown. {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:14765186, ECO:0000269|PubMed:9037020}.
Pathway Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:14765186, ECO:0000269|PubMed:9037020}.
Similarity Belongs to the fatty acid desaturase family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007805 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71999459 RefSeq NP_001023560 402 Protein FAT-1

Identical Sequences to LMP007805 proteins

Reference Database Accession Length Protein Name
GI:71999459 EMBL CAC44309.1 402 Protein FAT-1 [Caenorhabditis elegans]
GI:71999459 GenBank ADR85394.1 402 Sequence 69 from patent US 7736884
GI:71999459 SwissProt Q9NEQ0.1 402 RecName: Full=Omega-3 fatty acid desaturase fat-1; AltName: Full=Fatty acid desaturase 1 [Caenorhabditis elegans]

Related Sequences to LMP007805 proteins

Reference Database Accession Length Protein Name
GI:71999459 GenBank AAA67369.1 402 fatty acid desaturase [Caenorhabditis elegans]
GI:71999459 GenBank AAE60611.1 402 Sequence 2 from patent US 6194167
GI:71999459 GenBank AAN93253.1 402 Sequence 2 from patent US 6459018
GI:71999459 GenBank AAY69963.1 402 Sequence 2 from patent US 6884921
GI:71999459 GenBank ABE21477.1 402 Sequence 30 from patent US 7001772
GI:71999459 GenBank AFO18571.1 402 Sequence 30 from patent US 8206984