Gene/Proteome Database (LMPD)

LMPD ID
LMP007793
Gene ID
178293
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein FAT-2
Gene Symbol
fat-2
Synonyms
CELE_W02A2.1
Alternate Names
Protein FAT-2
Chromosome
IV
EC Number
1.14.19.-

Proteins

Protein FAT-2
Refseq ID NP_502560
Protein GI 17542730
UniProt ID G5EGA5
mRNA ID NM_070159
Length 376
RefSeq Status REVIEWED
MTIATKVNTNKKDLDTIKVPELPSVAAVKAAIPEHCFVKDPLTSISYLIKDYVLLAGLYFAVPYIEHYLGWIGLLGWYWAMGIVGSALFCVGHDCGHGSFSDYEWLNDLCGHLAHAPILAPFWPWQKSHRQHHQYTSHVEKDKGHPWVTEEDYNNRTAIEKYFAVIPISGWLRWNPIYTIVGLPDGSHFWPWSRLFETTEDRVKCAVSGVACAICAYIAFVLCDYSVYTFVKYYYIPLLFQGLILVIITYLQHQNEDIEVYEADEWGFVRGQTQTIDRHWGFGLDNIMHNITNGHVAHHFFFTKIPHYHLLEATPAIKKALEPLKDTQYGYKREVNYNWFFKYLHYNVTLDYLTHKAKGVLQYRSGVEAAKAKKAQ

Gene Information

Entrez Gene ID
178293
Gene Name
Protein FAT-2
Gene Symbol
fat-2
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016720 IMP:WormBase F delta12-fatty acid dehydrogenase activity
GO:0004768 IDA:WormBase F stearoyl-CoA 9-desaturase activity
GO:0040002 IMP:WormBase P collagen and cuticulin-based cuticle development
GO:0030497 IMP:WormBase P fatty acid elongation
GO:0045087 IEP:WormBase P innate immune response
GO:0000003 IMP:WormBase P reproduction
GO:0006636 IMP:WormBase P unsaturated fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
cel01040 Biosynthesis of unsaturated fatty acids
ko01040 Biosynthesis of unsaturated fatty acids
cel01212 Fatty acid metabolism
ko01212 Fatty acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1
IPR021863 Protein of unknown function DUF3474

UniProt Annotations

Entry Information

Gene Name
Protein FAT-2
Protein Entry
FAT2_CAEEL
UniProt ID
G5EGA5
Species
C. elegans

Comments

Comment Type Description
Function Catalyzes the desaturation of oleic acid (Delta(9)-18:1, or C18:1(n-9)) to linoleic acid (Delta(9,12)-18:2, or C18:2(n-6)). This desaturation event is essential for the synthesis of longer chain polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA, or C20:4(n-6)) and eicosapentaenoic acid (EPA, or C20:5(n- 3)). {ECO:0000269|PubMed:10775428, ECO:0000269|PubMed:11972048}.
Pathway Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000269|PubMed:10775428, ECO:0000269|PubMed:11972048}.
Similarity Belongs to the fatty acid desaturase family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007793 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17542730 RefSeq NP_502560 376 Protein FAT-2

Identical Sequences to LMP007793 proteins

Reference Database Accession Length Protein Name
GI:17542730 GenBank ACN01197.1 376 Sequence 32 from patent US 7479382
GI:17542730 GenBank ADF14318.1 376 Sequence 32 from patent US 7666642
GI:17542730 GenBank ADR85373.1 376 Sequence 48 from patent US 7736884
GI:17542730 GenBank AEN29056.1 376 Sequence 32 from patent US 7993894
GI:17542730 GenBank AHL37837.1 376 delta-12 desaturase [synthetic construct]
GI:17542730 SwissProt G5EGA5.1 376 RecName: Full=Delta(12) fatty acid desaturase fat-2; AltName: Full=Fatty acid desaturase 2 [Caenorhabditis elegans]

Related Sequences to LMP007793 proteins

Reference Database Accession Length Protein Name
GI:17542730 EMBL CAP22847.1 376 Protein CBR-FAT-2 [Caenorhabditis briggsae]
GI:17542730 GenBank EFP08096.1 374 CRE-FAT-2 protein [Caenorhabditis remanei]
GI:17542730 GenBank EGT37131.1 376 hypothetical protein CAEBREN_08652 [Caenorhabditis brenneri]
GI:17542730 GenBank EGT48003.1 376 hypothetical protein CAEBREN_24487 [Caenorhabditis brenneri]
GI:17542730 RefSeq XP_002634220.1 376 C. briggsae CBR-FAT-2 protein [Caenorhabditis briggsae]
GI:17542730 RefSeq XP_003090403.1 374 CRE-FAT-2 protein [Caenorhabditis remanei]