Gene/Proteome Database (LMPD)

LMPD ID
LMP007787
Gene ID
178956
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein HMGS-1
Gene Symbol
hmgs-1
Synonyms
CELE_F25B4.6
Alternate Names
Protein HMGS-1
Chromosome
V
EC Number
2.3.3.10

Proteins

Protein HMGS-1
Refseq ID NP_504496
Protein GI 17560126
UniProt ID P54871
mRNA ID NM_072095
Length 462
RefSeq Status REVIEWED
MSLGQLSYTPVTDVGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLTVTRKLIETYKISTDSIGCLVVGTETMIDKSKSVKTALMDLFPGNSDIEGVDIKNACFGGAQALLHAIDWVTVNHPLDKKNAIVVVADIAIYEEGPARCTGGAGAIAFLICPDASIPIDRQFSACHMKNTWDFFKPITPIPSEYPVVDGSLSLSSYLEAVRMTYTYFISKVNRHTTGIDGLNSFDGVFLHSPFTKMVQKGLAVMNYTDSQLRHKQLNGNGVDHKLDENDRAGLAKMIELSAQVWKEKTDPYLVFNRRIGNMYTPSLFAQLLAYLAADDCVTGEKSILFFAYGSGLASAIFPGRVRQTSNLDKIRQVAIRAIKRLDDRIQFTPEEFTETLQKREVFLRSKEIPKSPSETSLFPNTYFLDNMDKLYRRSYTLHEEPNGVQNGNGIHH

Gene Information

Entrez Gene ID
178956
Gene Name
Protein HMGS-1
Gene Symbol
hmgs-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004421 IEA:UniProtKB-EC F hydroxymethylglutaryl-CoA synthase activity
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process
GO:0016126 IEA:UniProtKB-KW P sterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
cel00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5653424 Activation of gene expression by SREBF (SREBP)
5652978 Cholesterol biosynthesis
5653288 PPARA activates gene expression

Domain Information

InterPro Annotations

Accession Description
IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
Protein HMGS-1
Protein Entry
HMCS_CAEEL
UniProt ID
P54871
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO:0000255|PROSITE- ProRule:PRU10116}.
Function This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. {ECO:0000250}.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Similarity Belongs to the HMG-CoA synthase family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007787 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17560126 RefSeq NP_504496 462 Protein HMGS-1

Identical Sequences to LMP007787 proteins

Reference Database Accession Length Protein Name
GI:17560126 EMBL CCD64508.1 462 Protein HMGS-1 [Caenorhabditis elegans]
GI:17560126 GenBank ABZ32394.1 462 Sequence 6332 from patent US 7314974
GI:17560126 GenBank AGU20680.1 462 Sequence 65 from patent US 8519225
GI:17560126 SwissProt P54871.2 462 RecName: Full=Hydroxymethylglutaryl-CoA synthase; Short=HMG-CoA synthase; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase [Caenorhabditis elegans]

Related Sequences to LMP007787 proteins

Reference Database Accession Length Protein Name
GI:17560126 EMBL CAP29227.1 463 Protein CBG09344 [Caenorhabditis briggsae]
GI:17560126 GenBank AAA92672.1 458 HMG CoA synthase, partial [Caenorhabditis elegans]
GI:17560126 GenBank EFP10929.1 466 hypothetical protein CRE_31059 [Caenorhabditis remanei]
GI:17560126 GenBank EGT47234.1 462 hypothetical protein CAEBREN_11369 [Caenorhabditis brenneri]
GI:17560126 RefSeq XP_002636883.1 463 Hypothetical protein CBG09344 [Caenorhabditis briggsae]
GI:17560126 RefSeq XP_003112408.1 466 hypothetical protein CRE_31059 [Caenorhabditis remanei]