Gene/Proteome Database (LMPD)

LMPD ID
LMP007728
Gene ID
946727
Species
Escherichia coli K-12 (E. coli)
Gene Name
acetyl-CoA acetyltransferase
Gene Symbol
atoB
Synonyms
ECK2217; JW2218
Summary
None
Orthologs
View orthologs and multiple alignments for atoB

Proteins

acetyl-CoA acetyltransferase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_416728
Protein GI 16130161
UniProt ID P76461
Length 394
RefSeq Status REVIEWED
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSQHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVCGFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGITAENVAKEYGITREMQDELALHSQRKAAAAIESGAFTAEIVPVNVVTRKKTFVFSQDEFPKANSTAEALGALRPAFDKAGTVTAGNASGINDGAAALVIMEESAALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKALQLAGLQLADIDLIEANEAFAAQFLAVGKNLGFDSEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN

Gene Information

Entrez Gene ID
946727
Gene Name
acetyl-CoA acetyltransferase
Gene Symbol
atoB
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0003985 IEA:UniProtKB-EC F acetyl-CoA C-acetyltransferase activity
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00362 Benzoate degradation
ko00362 Benzoate degradation
eco01110 Biosynthesis of secondary metabolites
eco00650 Butanoate metabolism
ko00650 Butanoate metabolism
eco01200 Carbon metabolism
ko01200 Carbon metabolism
eco00071 Fatty acid degradation
ko00071 Fatty acid degradation
eco01212 Fatty acid metabolism
ko01212 Fatty acid metabolism
eco00630 Glyoxylate and dicarboxylate metabolism
ko00630 Glyoxylate and dicarboxylate metabolism
eco00310 Lysine degradation
ko00310 Lysine degradation
eco01100 Metabolic pathways
eco01120 Microbial metabolism in diverse environments
eco00640 Propanoate metabolism
ko00640 Propanoate metabolism
eco00620 Pyruvate metabolism
ko00620 Pyruvate metabolism
eco00900 Terpenoid backbone biosynthesis
ko00900 Terpenoid backbone biosynthesis
eco00380 Tryptophan metabolism
ko00380 Tryptophan metabolism
eco02020 Two-component system
ko02020 Two-component system
eco00280 Valine, leucine and isoleucine degradation
ko00280 Valine, leucine and isoleucine degradation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7216 (R)- and (S)-3-hydroxybutyrate biosynthesis
ACETOACETATE-DEG-PWY acetoacetate degradation (to acetyl CoA)
ACETOACETATE-DEG-PWY acetoacetate degradation (to acetyl CoA)
PWY-7218 photosynthetic 3-hydroxybutyrate biosynthesis
PWY-6883 pyruvate fermentation to butanol II
PWY-6863 pyruvate fermentation to hexanol
PWY-5327 superpathway of lysine degradation

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA acetyltransferase
Protein Entry
ATOB_ECOLI
UniProt ID
P76461
Species
E. coli

Comments

Comment Type Description
Catalytic Activity 2 acetyl-CoA = CoA + acetoacetyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10020}.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007728 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16130161 RefSeq NP_416728 394 acetyl-CoA acetyltransferase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007728 proteins

Reference Database Accession Length Protein Name
GI:16130161 GenBank KHH87568.1 394 acetyl-CoA acetyltransferase [Escherichia coli]
GI:16130161 GenBank KHH98242.1 394 acetyl-CoA acetyltransferase [Escherichia coli]
GI:16130161 GenBank KHI15559.1 394 acetyl-CoA acetyltransferase [Escherichia coli]
GI:16130161 GenBank KHI19782.1 394 acetyl-CoA acetyltransferase [Escherichia coli]
GI:16130161 GenBank KHI60010.1 394 acetyl-CoA acetyltransferase [Escherichia coli]
GI:16130161 gnl IGS 394 acetyl-CoA acetyltransferase [Escherichia coli ER2796]

Related Sequences to LMP007728 proteins

Reference Database Accession Length Protein Name
GI:16130161 GenBank EGJ01145.1 394 acetyl-CoA acetyltransferase [Shigella dysenteriae 155-74]
GI:16130161 GenBank EIF83897.1 394 acetyl-CoA acetyltransferase [Escherichia coli M919]
GI:16130161 GenBank EMW34521.1 394 acetyl-CoA C-acetyltransferase family protein [Escherichia coli 2785200]
GI:16130161 gnl REF_tigr 394 acetyl-CoA acetyltransferase [Escherichia coli HS]
GI:16130161 RefSeq WP_000786546.1 394 acetyl-CoA acetyltransferase [Escherichia coli]
GI:16130161 RefSeq WP_001723720.1 394 acetyl-CoA C-acetyltransferase family protein [Escherichia coli]