Gene/Proteome Database (LMPD)

LMPD ID
LMP007694
Gene ID
948125
Species
Escherichia coli K-12 (E. coli)
Gene Name
glycerol-3-phosphate dehydrogenase (NAD+)
Gene Symbol
gpsA
Synonyms
ECK3598; JW3583
Summary
The enzyme catalyzes the NAD(P)H-dependent reduction of the glycolytic intermediate dihydroxyacetone-phosphate to produce glycerol-3-phosphate, a precursor for the biosynthesis of phospholipids . [More information is available at EcoCyc: EG20091].
Orthologs
View orthologs and multiple alignments for gpsA

Proteins

glycerol-3-phosphate dehydrogenase (NAD+) [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_418065
Protein GI 16131479
UniProt ID P0A6S7
Length 339
RefSeq Status REVIEWED
MNQRNASMTVIGAGSYGTALAITLARNGHEVVLWGHDPEHIATLERDRCNAAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFGEVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDQTFADDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVQSAQEKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKDERSSH

Gene Information

Entrez Gene ID
948125
Gene Name
glycerol-3-phosphate dehydrogenase (NAD+)
Gene Symbol
gpsA
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009331 IEA:InterPro C glycerol-3-phosphate dehydrogenase complex
GO:0051287 IEA:InterPro F NAD binding
GO:0047952 IDA:EcoCyc F glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO:0004367 IEA:UniProtKB-EC F glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0036439 IEA:UniProtKB-EC F glycerol-3-phosphate dehydrogenase [NADP+] activity
GO:0005975 IEA:InterPro P carbohydrate metabolic process
GO:0046167 IEA:UniProtKB-HAMAP P glycerol-3-phosphate biosynthetic process
GO:0046168 IEA:InterPro P glycerol-3-phosphate catabolic process
GO:0046474 IMP:EcoCyc P glycerophospholipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5667 CDP-diacylglycerol biosynthesis I
PWY-5667 CDP-diacylglycerol biosynthesis I
PWY0-1319 CDP-diacylglycerol biosynthesis II
PWY0-1319 CDP-diacylglycerol biosynthesis II
PHOSLIPSYN-PWY phospholipid biosynthesis I
PHOSLIPSYN-PWY phospholipid biosynthesis I

Domain Information

InterPro Annotations

Accession Description
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
glycerol-3-phosphate dehydrogenase (NAD+)
Protein Entry
GPDA_ECOLI
UniProt ID
P0A6S7
Species
E. coli

Comments

Comment Type Description
Catalytic Activity sn-glycerol 3-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H. {ECO:0000255|HAMAP-Rule:MF_00394}.
Pathway Membrane lipid metabolism; glycerophospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_00394}.
Similarity Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000255|HAMAP-Rule:MF_00394}.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00394}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007694 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16131479 RefSeq NP_418065 339 glycerol-3-phosphate dehydrogenase (NAD+) [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007694 proteins

Reference Database Accession Length Protein Name
GI:16131479 GenBank KHJ02514.1 339 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131479 GenBank KHJ07053.1 339 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131479 GenBank KHJ11028.1 339 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131479 GenBank KHJ20375.1 339 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131479 GenBank KHJ24197.1 339 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131479 gnl IGS 339 glycerol-3-phosphate dehydrogenase (NAD+) [Escherichia coli ER2796]

Related Sequences to LMP007694 proteins

Reference Database Accession Length Protein Name
GI:16131479 DBBJ GAL55506.1 339 glycerol-3-phosphate dehydrogenase [Escherichia albertii NBRC 107761]
GI:16131479 GenBank EDV68824.1 339 NAD-dependent glycerol-3-phosphate dehydrogenase [Escherichia coli F11]
GI:16131479 GenBank ENE62412.1 339 NAD-dependent glycerol-3-phosphate dehydrogenase family protein [Escherichia coli P0304777.13]
GI:16131479 RefSeq WP_001076186.1 339 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131479 RefSeq WP_001076193.1 339 MULTISPECIES: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Escherichia]
GI:16131479 RefSeq WP_001588215.1 339 NAD-dependent glycerol-3-phosphate dehydrogenase family protein [Escherichia coli]