Gene/Proteome Database (LMPD)

LMPD ID
LMP007687
Gene ID
947594
Species
Escherichia coli K-12 (E. coli)
Gene Name
2,4-dienoyl-CoA reductase, NADH and FMN-linked
Gene Symbol
fadH
Synonyms
ECK3071; JW3052; ygjL
Summary
FadH contains FMN, FAD, and a 4Fe-4S cluster. [More information is available at EcoGene: EG12723].
Orthologs
View orthologs and multiple alignments for fadH

Proteins

2,4-dienoyl-CoA reductase, NADH and FMN-linked [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_417552
Protein GI 16130976
UniProt ID P42593
Length 672
RefSeq Status REVIEWED
MSYPSLFAPLDLGFTTLKNRVLMGSMHTGLEEYPDGAERLAAFYAERARHGVALIVSGGIAPDLTGVGMEGGAMLNDASQIPHHRTITEAVHQEGGKIALQILHTGRYSYQPHLVAPSALQAPINRFVPHELSHEEILQLIDNFARCAQLAREAGYDGVEVMGSEGYLINEFLTLRTNQRSDQWGGDYRNRMRFAVEVVRAVRERVGNDFIIIYRLSMLDLVEDGGTFAETVELAQAIEAAGATIINTGIGWHEARIPTIATPVPRGAFSWVTRKLKGHVSLPLVTTNRINDPQVADDILSRGDADMVSMARPFLADAELLSKAQSGRADEINTCIGCNQACLDQIFVGKVTSCLVNPRACHETKMPILPAVQKKNLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEIGGQFNIAKQIPGKEEFYETLRYYRRMIEVTGVTLKLNHTVTADQLQAFDETILASGIVPRTPPIDGIDHPKVLSYLDVLRDKAPVGNKVAIIGCGGIGFDTAMYLSQPGESTSQNIAGFCNEWGIDSSLQQAGGLSPQGMQIPRSPRQIVMLQRKASKPGQGLGKTTGWIHRTTLLSRGVKMIPGVSYQKIDDDGLHVVINGETQVLAVDNVVICAGQEPNRALAQPLIDSGKTVHLIGGCDVAMELDARRAIAQGTRLALEI

Gene Information

Entrez Gene ID
947594
Gene Name
2,4-dienoyl-CoA reductase, NADH and FMN-linked
Gene Symbol
fadH
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008670 IGI:EcoCyc F 2,4-dienoyl-CoA reductase (NADPH) activity
GO:0051539 IEA:UniProtKB-KW F 4 iron, 4 sulfur cluster binding
GO:0010181 IEA:InterPro F FMN binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding

Domain Information

InterPro Annotations

Accession Description
IPR013785 Aldolase-type TIM barrel
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
2,4-dienoyl-CoA reductase, NADH and FMN-linked
Protein Entry
FADH_ECOLI
UniProt ID
P42593
Species
E. coli

Comments

Comment Type Description
Catalytic Activity Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Domain The N-terminus may contain the FAD-binding domain whereas the NADPH-binding domain may be located in the C-terminus.
Function Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA.
Subunit Monomer.

Identical and Related Proteins

Unique RefSeq proteins for LMP007687 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16130976 RefSeq NP_417552 672 2,4-dienoyl-CoA reductase, NADH and FMN-linked [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007687 proteins

Reference Database Accession Length Protein Name
GI:16130976 GenBank KHH94706.1 672 2,4-dienoyl-CoA reductase [Escherichia coli]
GI:16130976 GenBank KHI18592.1 672 2,4-dienoyl-CoA reductase [Escherichia coli]
GI:16130976 GenBank KHI21702.1 672 2,4-dienoyl-CoA reductase [Escherichia coli]
GI:16130976 GenBank KHI58656.1 672 2,4-dienoyl-CoA reductase [Escherichia coli]
GI:16130976 GenBank KHI99253.1 672 2,4-dienoyl-CoA reductase [Escherichia coli]
GI:16130976 gnl IGS 672 2,4-dienoyl-CoA reductase, NADH and FMN-linked [Escherichia coli ER2796]

Related Sequences to LMP007687 proteins

Reference Database Accession Length Protein Name
GI:16130976 GenBank EKJ83811.1 672 2,4-dienoyl-CoA reductase [Escherichia coli AD30]
GI:16130976 GenBank KDT72077.1 672 2,4-dienoyl-CoA reductase [Escherichia coli 3-373-03_S3_C1]
GI:16130976 PDB 1PS9 671 Chain A, The Crystal Structure And Reaction Mechanism Of E. Coli 2,4- Dienoyl Coa Reductase
GI:16130976 RefSeq WP_000121436.1 672 2,4-dienoyl-CoA reductase [Escherichia coli]
GI:16130976 RefSeq WP_025670448.1 672 2,4-dienoyl-CoA reductase [Escherichia coli]
GI:16130976 RefSeq WP_032259020.1 672 2,4-dienoyl-CoA reductase [Escherichia coli]