Gene/Proteome Database (LMPD)

LMPD ID
LMP007677
Gene ID
948629
Species
Escherichia coli K-12 (E. coli)
Gene Name
lipid A phosphoethanolamine transferase
Gene Symbol
eptA
Synonyms
ECK4107; JW5730; pagB; pmrC; yjdB
Summary
EptA co-localizes with ZipA. [More information is available at EcoGene: EG11613]. The YjdB protein can be found in the membrane in a complex with ZipA and an unidentified 24 kDa protein . [More information is available at EcoCyc: EG11613].
Orthologs
View orthologs and multiple alignments for eptA

Proteins

lipid A phosphoethanolamine transferase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_418538
Protein GI 90111688
UniProt ID P30845
Length 547
RefSeq Status REVIEWED
MLKRLLKRPSLNLLAWLLLAAFYISICLNIAFFKQVLQALPLDSLHNVLVFLSMPVVAFSVINIVLTLSSFLWLNRPLACLFILVGAAAQYFIMTYGIVIDRSMIANIIDTTPAESYALMTPQMLLTLGFSGVLAALIACWIKIKPATSRLRSVLFRGANILVSVLLILLVAALFYKDYASLFRNNKELVKSLSPSNSIVASWSWYSHQRLANLPLVRIGEDAHRNPLMQNEKRKNLTILIVGETSRAENFSLNGYPRETNPRLAKDNVVYFPNTASCGTATAVSVPCMFSDMPREHYKEELAQHQEGVLDIIQRAGINVLWNDNDGGCKGACDRVPHQNVTALNLPDQCINGECYDEVLFHGLEEYINNLQGDGVIVLHTIGSHGPTYYNRYPPQFRKFTPTCDTNEIQTCTKEQLVNTYDNTLVYVDYIVDKAINLLKEHQDKFTTSLVYLSDHGESLGENGIYLHGLPYAIAPDSQKQVPMLLWLSEDYQKRYQVDQNCLQKQAQTQHYSQDNLFSTLLGLTGVETKYYQAADDILQTCRRVSE

Gene Information

Entrez Gene ID
948629
Gene Name
lipid A phosphoethanolamine transferase
Gene Symbol
eptA
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0016776 TAS:EcoCyc F phosphotransferase activity, phosphate group as acceptor
GO:0008484 IEA:InterPro F sulfuric ester hydrolase activity
GO:0009245 IEA:UniProtKB-KW P lipid A biosynthetic process
GO:0009103 TAS:EcoCyc P lipopolysaccharide biosynthetic process
GO:0046677 IEA:UniProtKB-KW P response to antibiotic

Domain Information

InterPro Annotations

Accession Description
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
IPR017850 Alkaline-phosphatase-like, core domain
IPR012549 DUF1705
IPR000917 Sulfatase

UniProt Annotations

Entry Information

Gene Name
lipid A phosphoethanolamine transferase
Protein Entry
EPTA_ECOLI
UniProt ID
P30845
Species
E. coli

Comments

Comment Type Description
Function Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin (By similarity). {ECO:0000250}.
Induction The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions. {ECO:0000250}.
Sequence Caution Sequence=AAA97013.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Belongs to the phosphoethanolamine transferase family. EptA subfamily. {ECO:0000305}.
Subcellular Location Cell inner membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}.
Subunit Has been isolated as a 91 kDa complex containing ZipA- EptA and an unidentified 24 kDa protein. {ECO:0000269|PubMed:16079137}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007677 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
90111688 RefSeq NP_418538 547 lipid A phosphoethanolamine transferase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007677 proteins

Reference Database Accession Length Protein Name
GI:90111688 GenBank KGT31805.1 547 hydrolase [Escherichia coli]
GI:90111688 GenBank KHH69521.1 547 hydrolase [Escherichia coli]
GI:90111688 GenBank KHH74089.1 547 hydrolase [Escherichia coli]
GI:90111688 GenBank KHH95014.1 547 hydrolase [Escherichia coli]
GI:90111688 GenBank KHH98115.1 547 hydrolase [Escherichia coli]
GI:90111688 gnl IGS 547 lipid A phosphoethanolamine transferase [Escherichia coli ER2796]

Related Sequences to LMP007677 proteins

Reference Database Accession Length Protein Name
GI:90111688 GenBank ACI73691.1 557 hypothetical protein ECs5096 [Escherichia coli]
GI:90111688 GenBank ACI73692.1 557 hypothetical protein ECs5096 [Escherichia coli]
GI:90111688 GenBank ACI73693.1 557 hypothetical protein ECs5096 [Escherichia coli]
GI:90111688 GenBank ACI73695.1 557 hypothetical protein ECs5096 [Escherichia coli]
GI:90111688 gnl nankaitd 557 putative cell division protein [Escherichia coli Xuzhou21]
GI:90111688 RefSeq YP_006093768.1 557 sulfatase [Escherichia coli DH1]