Gene/Proteome Database (LMPD)

LMPD ID
LMP007665
Gene ID
946211
Species
Escherichia coli K-12 (E. coli)
Gene Name
putative acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit
Gene Symbol
ydiF
Synonyms
ECK1692; JW1684
Summary
Family I CoA transferase. [More information is available at EcoGene: EG12432]. Based on sequence similarity, YdiF is predicted to be an acetate CoA-transferase . [More information is available at EcoCyc: EG12432].
Orthologs
View orthologs and multiple alignments for ydiF

Proteins

putative acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_416209
Protein GI 16129650
UniProt ID P37766
Length 531
RefSeq Status REVIEWED
MKPVKPPRINGRVPVLSAQEAVNYIPDEATLCVLGAGGGILEATTLITALADKYKQTQTPRNLSIISPTGLGDRADRGISPLAQEGLVKWALCGHWGQSPRISELAEQNKIIAYNYPQGVLTQTLRAAAAHQPGIISDIGIGTFVDPRQQGGKLNEVTKEDLIKLVEFDNKEYLYYKAIAPDIAFIRATTCDSEGYATFEDEVMYLDALVIAQAVHNNGGIVMMQVQKMVKKATLHPKSVRIPGYLVDIVVVDPDQTQLYGGAPVNRFISGDFTLDDSTKLSLPLNQRKLVARRALFEMRKGAVGNVGVGIADGIGLVAREEGCADDFILTVETGPIGGITSQGIAFGANVNTRAILDMTSQFDFYHGGGLDVCYLSFAEVDQHGNVGVHKFNGKIMGTGGFIDISATSKKIIFCGTLTAGSLKTEITDGKLNIVQEGRVKKFIRELPEITFSGKIALERGLDVRYITERAVFTLKEDGLHLIEIAPGVDLQKDILDKMDFTPVISPELKLMDERLFIDAAMGFVLPEAAH

Gene Information

Entrez Gene ID
946211
Gene Name
putative acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit
Gene Symbol
ydiF
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008775 ISS:UniProtKB F acetate CoA-transferase activity
GO:0046952 IEA:InterPro P ketone body catabolic process
GO:0051289 ISS:UniProtKB P protein homotetramerization
GO:0046459 ISS:UniProtKB P short-chain fatty acid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR014388 3-oxoacid_CoA-transferase
IPR004165 Coenzyme A transferase family I

UniProt Annotations

Entry Information

Gene Name
putative acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit
Protein Entry
YDIF_ECOLI
UniProt ID
P37766
Species
E. coli

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.
Function CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. May play a role in short-chain fatty acid metabolism in E.coli (By similarity). {ECO:0000250}.
Miscellaneous Formation of the covalent enzyme-CoA thioester intermediate proceeds via an unstable anhydride species formed between the carboxylate group of the catalytic glutamate of the enzyme and the carbonyl carbon of the thioester linkage of the substrate. {ECO:0000250}.
Similarity Belongs to the 3-oxoacid CoA-transferase family. {ECO:0000305}.
Subunit Homotetramer; dimer of dimers. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007665 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16129650 RefSeq NP_416209 531 putative acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007665 proteins

Reference Database Accession Length Protein Name
GI:16129650 GenBank KHH89928.1 531 acetate CoA-transferase YdiF [Escherichia coli]
GI:16129650 GenBank KHH96122.1 531 acetate CoA-transferase YdiF [Escherichia coli]
GI:16129650 GenBank KHI15984.1 531 acetate CoA-transferase YdiF [Escherichia coli]
GI:16129650 GenBank KHI17767.1 531 acetate CoA-transferase YdiF [Escherichia coli]
GI:16129650 GenBank KHI60990.1 531 acetate CoA-transferase YdiF [Escherichia coli]
GI:16129650 gnl IGS 531 fused predicted acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit [Escherichia coli ER2796]

Related Sequences to LMP007665 proteins

Reference Database Accession Length Protein Name
GI:16129650 GenBank EFU58950.1 531 CoA transferase [Escherichia coli MS 16-3]
GI:16129650 GenBank EGB76255.1 531 CoA transferase [Escherichia coli MS 57-2]
GI:16129650 GenBank EGI21264.1 531 hypothetical protein ECJG_02639 [Escherichia coli M718]
GI:16129650 GenBank ELF66603.1 531 acetyl-CoA:acetoacetyl-CoA transferase alpha/beta subunit [Escherichia coli KTE45]
GI:16129650 GenBank ELF96925.1 531 acetyl-CoA:acetoacetyl-CoA transferase alpha/beta subunit [Escherichia coli KTE46]
GI:16129650 GenBank ESA76000.1 531 CoA transferase [Escherichia coli 113290]