Gene/Proteome Database (LMPD)

LMPD ID
LMP007650
Gene ID
944886
Species
Escherichia coli K-12 (E. coli)
Gene Name
putative crotonobetaine/carnitine-CoA ligase
Gene Symbol
caiC
Synonyms
ECK0038; JW0036; yaaM
Summary
Simliarity comparisons with Salmonella, Desulfotomaculum, Shewanella and Proteus CaiC homologs indicate that the second ATG is the likely start site, which also has a good predicted RBS of GGAG (Personal communication, G. [More information is available at EcoGene: EG11558]. Carnitine-CoA ligase (CaiC) catalyzes the transfer of CoA to carnitine. [More information is available at EcoCyc: EG11558].
Orthologs
View orthologs and multiple alignments for caiC

Proteins

putative crotonobetaine/carnitine-CoA ligase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_414579
Protein GI 221800780
UniProt ID P31552
Length 517
RefSeq Status REVIEWED
MDIIGGQHLRQMWDDLADVYGHKTALICESSGGVVNRYSYLELNQEINRTANLFYTLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLCEESAWILQNSQACLLVTSAQFYPMYQQIQQEDATQLRHICLTDVALPADDGVSSFTQLKNQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHIDCQCTAAMAAFSAGATFVLVEKYSARAFWGQVQKYRATVTECIPMMIRTLMVQPPSANDQQHRLREVMFYLNLSEQEKDAFCERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRVGFCYEAEIRDDHNRPLPAGEIGEICIKGIPGKTIFKEYFLNPQATAKVLEADGWLHTGDTGYRDEEDFFYFVDRRCNMIKRGGENVSCVELENIIAAHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFRFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIRKNLK

Gene Information

Entrez Gene ID
944886
Gene Name
putative crotonobetaine/carnitine-CoA ligase
Gene Symbol
caiC
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016878 IEA:InterPro F acid-thiol ligase activity
GO:0051108 IDA:EcoCyc F carnitine-CoA ligase activity
GO:0051109 IDA:EcoCyc F crotonobetaine-CoA ligase activity
GO:0009437 IEA:UniProtKB-UniPathway P carnitine metabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
CARNMET-PWY carnitine degradation I
CARNMET-PWY carnitine degradation I
CARNMET-PWY carnitine degradation I

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase
IPR023456 CaiC

UniProt Annotations

Entry Information

Gene Name
putative crotonobetaine/carnitine-CoA ligase
Protein Entry
CAIC_ECOLI
UniProt ID
P31552
Species
E. coli

Comments

Comment Type Description
Function Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.
Interaction P0ACN4:allR; NbExp=3; IntAct=EBI-1112975, EBI-561736;
Pathway Amine and polyamine metabolism; carnitine metabolism.
Sequence Caution Sequence=BAB96606.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA52113.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007650 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
221800780 RefSeq NP_414579 517 putative crotonobetaine/carnitine-CoA ligase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007650 proteins

Reference Database Accession Length Protein Name
GI:221800780 EMBL CDY54526.1 517 carnitine-CoA ligase [Escherichia coli]
GI:221800780 EMBL CDZ18942.1 517 carnitine-CoA ligase [Escherichia coli]
GI:221800780 GenBank KGA88421.1 517 crotonobetainyl-CoA:carnitine CoA-transferase [Escherichia coli]
GI:221800780 GenBank KGL72181.1 517 crotonobetaine/carnitine-CoA ligase [Escherichia coli NCTC 50110]
GI:221800780 gnl PRJNA257976 517 putative crotonobetaine/carnitine-CoA ligase [Escherichia coli BW25113]
GI:221800780 gnl IGS 517 putative crotonobetaine/carnitine-CoA ligase [Escherichia coli ER2796]

Related Sequences to LMP007650 proteins

Reference Database Accession Length Protein Name
GI:221800780 DBBJ BAL37350.1 522 predicted crotonobetaine CoA ligase:carnitine CoA ligase [Escherichia coli str. K-12 substr. MDS42]
GI:221800780 GenBank ABZ26755.1 522 Sequence 693 from patent US 7314974
GI:221800780 gnl ecoli 522 predicted crotonobetaine CoA ligase:carnitine CoA ligase [Escherichia coli str. K-12 substr. DH10B]
GI:221800780 gnl REF_ecoli 522 putative crotonobetaine/carnitine-CoA ligase [Escherichia coli str. K-12 substr. DH10B]
GI:221800780 RefSeq WP_000373649.1 522 crotonobetaine/carnitine-CoA ligase [Escherichia coli]
GI:221800780 RefSeq YP_007555743.1 522 predicted crotonobetaine CoA ligase:carnitine CoA ligase [Escherichia coli str. K-12 substr. MDS42]