Gene/Proteome Database (LMPD)

LMPD ID
LMP007645
Gene ID
945791
Species
Escherichia coli K-12 (E. coli)
Gene Name
phosphatidylglycerophosphate synthetase
Gene Symbol
pgsA
Synonyms
ECK1911; JW1897
Summary
Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG10706].
Orthologs
View orthologs and multiple alignments for pgsA

Proteins

phosphatidylglycerophosphate synthetase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_416422
Protein GI 16129859
UniProt ID P0ABF8
Length 182
RefSeq Status REVIEWED
MQFNIPTLLTLFRVILIPFFVLVFYLPVTWSPFAAALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVLVAIAMVLVTEHYHSWWVTLPAATMIAREIIISALREWMAELGKRSSVAVSWIGKVKTTAQMVALAWLLWRPNIWVEYAGIALFFVAAVLTLWSMLQYLSAARADLLDQ

Gene Information

Entrez Gene ID
945791
Gene Name
phosphatidylglycerophosphate synthetase
Gene Symbol
pgsA
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IDA:EcoliWiki C integral component of membrane
GO:0005886 IEA:UniProtKB-HAMAP C plasma membrane
GO:0008444 IEA:UniProtKB-HAMAP F CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0006655 IEA:UniProtKB-UniPathway P phosphatidylglycerol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism
eco01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5668 cardiolipin biosynthesis I
PWY-5668 cardiolipin biosynthesis I
PWY-5668 cardiolipin biosynthesis I
PWY0-1545 cardiolipin biosynthesis III
PWY0-1545 cardiolipin biosynthesis III
PWY4FS-7 phosphatidylglycerol biosynthesis I (plastidic)
PWY4FS-8 phosphatidylglycerol biosynthesis II (non-plastidic)
PHOSLIPSYN-PWY phospholipid biosynthesis I
PHOSLIPSYN-PWY phospholipid biosynthesis I
PHOSLIPSYN-PWY phospholipid biosynthesis I

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase
IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
IPR023762 PGP_synthase_bac

UniProt Annotations

Entry Information

Gene Name
phosphatidylglycerophosphate synthetase
Protein Entry
PGSA_ECOLI
UniProt ID
P0ABF8
Species
E. coli

Comments

Comment Type Description
Catalytic Activity CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Function This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
Pathway Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular Location Cell inner membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007645 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16129859 RefSeq NP_416422 182 phosphatidylglycerophosphate synthetase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007645 proteins

Reference Database Accession Length Protein Name
GI:16129859 GenBank KHJ02071.1 182 phosphatidylglycerophosphate synthetase [Escherichia coli]
GI:16129859 GenBank KHJ04515.1 182 phosphatidylglycerophosphate synthetase [Escherichia coli]
GI:16129859 GenBank KHJ14355.1 182 phosphatidylglycerophosphate synthetase [Escherichia coli]
GI:16129859 GenBank KHJ24993.1 182 phosphatidylglycerophosphate synthetase [Escherichia coli]
GI:16129859 GenBank KHJ29641.1 182 phosphatidylglycerophosphate synthetase [Escherichia coli]
GI:16129859 gnl IGS 182 phosphatidylglycerophosphate synthetase [Escherichia coli ER2796]

Related Sequences to LMP007645 proteins

Reference Database Accession Length Protein Name
GI:16129859 GenBank ELF12673.1 182 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase [Escherichia coli KTE142]
GI:16129859 GenBank ELF20017.1 182 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase [Escherichia coli KTE156]
GI:16129859 GenBank EZJ38600.1 182 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Escherichia coli 1-250-04_S4_C2]
GI:16129859 GenBank KDT73978.1 182 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Escherichia coli 3-373-03_S3_C3]
GI:16129859 GenBank KDU08187.1 182 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Escherichia coli 3-373-03_S3_C2]
GI:16129859 RefSeq WP_001569991.1 182 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase [Escherichia coli]