Gene/Proteome Database (LMPD)

LMPD ID
LMP007591
Gene ID
948540
Species
Escherichia coli K-12 (E. coli)
Gene Name
p-hydroxybenzoate octaprenyltransferase
Gene Symbol
ubiA
Synonyms
ECK4032; JW4000; cyr; sdgG?
Summary
4-Hydroxybenzoate octaprenyltransferase is the second enzyme in the pathway of ubiquinone biosynthesis. [More information is available at EcoCyc: EG11370].
Orthologs
View orthologs and multiple alignments for ubiA

Proteins

p-hydroxybenzoate octaprenyltransferase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_418464
Protein GI 16131866
UniProt ID P0AGK1
Length 290
RefSeq Status REVIEWED
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF

Gene Information

Entrez Gene ID
948540
Gene Name
p-hydroxybenzoate octaprenyltransferase
Gene Symbol
ubiA
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0008412 IDA:EcoliWiki F 4-hydroxybenzoate octaprenyltransferase activity
GO:0016765 IDA:EcoCyc F transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0006744 IMP:EcoCyc P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
eco01110 Biosynthesis of secondary metabolites
eco01100 Metabolic pathways
eco00130 Ubiquinone and other terpenoid-quinone biosynthesis
ko00130 Ubiquinone and other terpenoid-quinone biosynthesis
M00117 Ubiquinone biosynthesis, prokaryotes, chorismate => ubiquinone
eco_M00117 Ubiquinone biosynthesis, prokaryotes, chorismate => ubiquinone

BIOCYC Pathway Links

BIOCYC Pathway ID Description
ALL-CHORISMATE-PWY superpathway of chorismate metabolism
ALL-CHORISMATE-PWY superpathway of chorismate metabolism
UBISYN-PWY superpathway of ubiquinol-8 biosynthesis (prokaryotic)
UBISYN-PWY superpathway of ubiquinol-8 biosynthesis (prokaryotic)
PWY-6708 ubiquinol-8 biosynthesis (prokaryotic)
UBISYN-PWY ubiquinol-8 biosynthesis (prokaryotic)
PWY-6708 ubiquinol-8 biosynthesis (prokaryotic)

Domain Information

InterPro Annotations

Accession Description
IPR006370 4-hydroxybenzoate polyprenyl transferase
IPR000537 UbiA prenyltransferase family

UniProt Annotations

Entry Information

Gene Name
p-hydroxybenzoate octaprenyltransferase
Protein Entry
UBIA_ECOLI
UniProt ID
P0AGK1
Species
E. coli

Comments

Comment Type Description
Catalytic Activity 4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Function Synthesis of 3-octaprenyl-4-hydroxybenzoate.
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Similarity Belongs to the UbiA prenyltransferase family. {ECO:0000305}.
Subcellular Location Cell inner membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007591 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16131866 RefSeq NP_418464 290 p-hydroxybenzoate octaprenyltransferase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007591 proteins

Reference Database Accession Length Protein Name
GI:16131866 GenBank KHI32691.1 290 4-hydroxybenzoate polyprenyltransferase [Escherichia coli]
GI:16131866 GenBank KHI42183.1 290 4-hydroxybenzoate polyprenyltransferase [Escherichia coli]
GI:16131866 GenBank KHI62944.1 290 4-hydroxybenzoate polyprenyltransferase [Escherichia coli]
GI:16131866 GenBank KHI85357.1 290 4-hydroxybenzoate polyprenyltransferase [Escherichia coli]
GI:16131866 GenBank KHI91741.1 290 4-hydroxybenzoate polyprenyltransferase [Escherichia coli]
GI:16131866 gnl IGS 290 p-hydroxybenzoate octaprenyltransferase [Escherichia coli ER2796]

Related Sequences to LMP007591 proteins

Reference Database Accession Length Protein Name
GI:16131866 GenBank EFZ60058.1 290 4-hydroxybenzoate polyprenyl transferase [Escherichia coli LT-68]
GI:16131866 GenBank EOW12910.1 290 4-hydroxybenzoate octaprenyltransferase [Escherichia coli KTE102]
GI:16131866 GenBank EYZ05372.1 290 4-hydroxybenzoate polyprenyltransferase [Escherichia coli O177:NM str. 2010C-4558]
GI:16131866 GenBank EZE00884.1 290 4-hydroxybenzoate polyprenyltransferase [Escherichia coli O145:H28 str. 2009C-3292]
GI:16131866 GenBank KDV37642.1 290 4-hydroxybenzoate polyprenyltransferase [Escherichia coli O145:H25 str. 07-3858]
GI:16131866 RefSeq WP_000455222.1 290 4-hydroxybenzoate polyprenyltransferase [Escherichia coli]