LIPID MAPS

LMPD ID

LMP007538

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Vta1p

Gene Symbol

VTA1

Synonyms

-

Alternate Names

Vta1p

Chromosome

XII

Vta1p
Refseq ID	NP_013282
Protein GI	6323210
UniProt ID	Q06263
mRNA ID	NM_001182068
Length	330
RefSeq Status	PROVISIONAL
MASNAARVVATAKDFDKVGLGIIGYYLQLYAVELILSEEDRSQEMTALATELLDTIEAFKKEIGGESEAEDSDKSLHVMNTLIHDQEKAKIYMLNFTMSLYNEKLKQLKDGPWDVMLKRSLWCCIDLFSCILHLWKENISETSTNSLQKRIKYCKIYLSKLAKGEIGSSDEKTLDYADFADDSEEIKDEDVDHQTSDLENNNNDKVEGLAPKDQTTSYEPVDEVPEFIDDADSVNEEEQTVDKNEDAITKDEQQVVKKEVDLTRPSAPSEPAAAEHKSYTKDELTKIMDRASKIEQIQKLAKYAISALNYEDLPTAKDELTKALDLLNSI

Entrez Gene ID

Gene Name

Vta1p

Gene Symbol

VTA1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0016020	IEA:UniProtKB-KW	C	membrane
GO:0005771	IDA:SGD	C	multivesicular body
GO:0001671	IDA:SGD	F	ATPase activator activity
GO:0045324	IMP:SGD	P	late endosome to vacuole transport
GO:0032511	IGI:SGD	P	late endosome to vacuole transport via multivesicular body sorting pathway
GO:0006869	IEA:UniProtKB-KW	P	lipid transport
GO:0032781	IDA:GOC	P	positive regulation of ATPase activity
GO:0032461	IDA:SGD	P	positive regulation of protein oligomerization
GO:0015031	IEA:UniProtKB-KW	P	protein transport

KEGG Pathway ID	Description
ko04144	Endocytosis
sce04144	Endocytosis

Accession	Description
IPR023175	Vacuolar protein sorting-associate protein Vta1/Callose synthase, N-terminal domain

Gene Name

Vta1p

Protein Entry

VTA1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold. {ECO:0000269\|PubMed:12953057, ECO:0000269\|PubMed:14701806, ECO:0000269\|PubMed:16505166, ECO:0000269\|PubMed:16601096}.
Interaction	P52917:VPS4; NbExp=7; IntAct=EBI-37098, EBI-20475;
Miscellaneous	Present with 4400 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the VTA1 family. {ECO:0000305}.
Subcellular Location	Cytoplasm. Endosome membrane; Peripheral membrane protein.
Subunit	Homodimer (in cytoplasm). Interacts with VPS4; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex; the interaction is ADP-dependent. Interacts with SNF7; the interaction requires DID2. Interacts with DID2. Interacts with VPS60; the interaction occurs at he endosomal membrane. {ECO:0000269\|PubMed:12953057, ECO:0000269\|PubMed:14701806, ECO:0000269\|PubMed:15086794, ECO:0000269\|PubMed:16505166, ECO:0000269\|PubMed:16601096, ECO:0000269\|PubMed:18032584, ECO:0000269\|PubMed:18194651, ECO:0000269\|PubMed:18194652, ECO:0000269\|PubMed:18280501}.

Protein GI	Database	Accession	Length	Protein Name
6323210	RefSeq	NP_013282	330	Vta1p

Reference	Database	Accession	Length	Protein Name
GI:6323210	EMBL	CAL48159.1	330	unnamed protein product [Saccharomyces cerevisiae]
GI:6323210	GenBank	AAB67473.1	330	Ylr181cp [Saccharomyces cerevisiae]
GI:6323210	GenBank	EIW08790.1	330	Vta1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323210	SwissProt	Q06263.1	330	RecName: Full=Vacuolar protein sorting-associated protein VTA1; AltName: Full=VPS20-associated protein 1 [Saccharomyces cerevisiae S288c]
GI:6323210	Third Party Genbank	DAA09501.1	330	TPA: Vta1p [Saccharomyces cerevisiae S288c]

Reference	Database	Accession	Length	Protein Name
GI:6323210	EMBL	CAY81418.1	330	Vta1p [Saccharomyces cerevisiae EC1118]
GI:6323210	GenBank	AAA66933.1	330	unknown protein [Saccharomyces cerevisiae]
GI:6323210	GenBank	EDN59405.1	330	Vps20 associated protein [Saccharomyces cerevisiae YJM789]
GI:6323210	GenBank	EEU09276.1	330	Vta1p [Saccharomyces cerevisiae JAY291]
GI:6323210	GenBank	EGA57631.1	330	Vta1p [Saccharomyces cerevisiae FostersB]
GI:6323210	GenBank	EWG94361.1	330	Vta1p [Saccharomyces cerevisiae R103]