Gene/Proteome Database (LMPD)

LMPD ID
LMP007532
Gene ID
854287
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
glycerol 2-dehydrogenase (NADP(+)) GCY1
Gene Symbol
GCY1
Synonyms
-
Chromosome
XV
EC Number
1.1.1.156

Proteins

glycerol 2-dehydrogenase (NADP(+)) GCY1
Refseq ID NP_014763
Protein GI 6324694
UniProt ID P14065
mRNA ID NM_001183539
Length 312
MPATLHDSTKILSLNTGAQIPQIGLGTWQSKENDAYKAVLTALKDGYRHIDTAAIYRNEDQVGQAIKDSGVPREEIFVTTKLWCTQHHEPEVALDQSLKRLGLDYVDLYLMHWPARLDPAYIKNEDILSVPTKKDGSRAVDITNWNFIKTWELMQELPKTGKTKAVGVSNFSINNLKDLLASQGNKLTPAANQVEIHPLLPQDELINFCKSKGIVVEAYSPLGSTDAPLLKEPVILEIAKKNNVQPGHVVISWHVQRGYVVLPKSVNPDRIKTNRKIFTLSTEDFEAINNISKEKGEKRVVHPNWSPFEVFK

Gene Information

Entrez Gene ID
854287
Gene Name
glycerol 2-dehydrogenase (NADP(+)) GCY1
Gene Symbol
GCY1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0004032 IDA:SGD F alditol:NADP+ 1-oxidoreductase activity
GO:0004033 IDA:SGD F aldo-keto reductase (NADP) activity
GO:0047953 IEA:UniProtKB-EC F glycerol 2-dehydrogenase (NADP+) activity
GO:1990042 IMP:SGD F glycerol dehydrogenase [NAD(P)+] activity
GO:0003729 IDA:SGD F mRNA binding
GO:0016491 IDA:SGD F oxidoreductase activity
GO:0042843 IDA:SGD P D-xylose catabolic process
GO:0019568 IDA:SGD P arabinose catabolic process
GO:0034599 IGI:SGD P cellular response to oxidative stress
GO:0006071 IEA:UniProtKB-KW P glycerol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
sce00561 Glycerolipid metabolism
sce01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR001395 Aldo/keto reductase
IPR020471 Aldo/keto reductase subgroup
IPR018170 Aldo/keto reductase, conserved site
IPR023210 NADP-dependent oxidoreductase domain

UniProt Annotations

Entry Information

Gene Name
glycerol 2-dehydrogenase (NADP(+)) GCY1
Protein Entry
GCY1_YEAST
UniProt ID
P14065
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=11.3 mM for D,L-glyceraldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.007 mM for NADPH {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.13 mM for p-nitrobenzaldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=5.2 mM for benzaldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=8.7 mM for phenylglyoxal {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=50 mM for acrolein {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=54 mM for butyraldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.724 mM for ethyl-4-chloro-3-oxo-butanoate {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562};
Biophysicochemical Properties Kinetic parameters: KM=11.3 mM for D,L-glyceraldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.007 mM for NADPH {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.13 mM for p-nitrobenzaldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=5.2 mM for benzaldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=8.7 mM for phenylglyoxal {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=50 mM for acrolein {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=54 mM for butyraldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.724 mM for ethyl-4-chloro-3-oxo-butanoate {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562};
Catalytic Activity Glycerol + NADP(+) = glycerone + NADPH. {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}.
Function Glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. Has mRNA binding activity. {ECO:0000269|PubMed:11113971, ECO:0000269|PubMed:15127164, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:22979944, ECO:0000269|PubMed:23770562, ECO:0000269|PubMed:23896974}.
Induction Expression is under the control of GAL4 and REB1, and is both positively controlled by galactose and negatively by glucose. Also induced by salt stress and in response to DNA replication stress. {ECO:0000269|PubMed:12536147, ECO:0000269|PubMed:2199324, ECO:0000269|PubMed:22842922, ECO:0000269|PubMed:9038161, ECO:0000269|PubMed:9435793}.
Similarity Belongs to the aldo/keto reductase family
Similarity Belongs to the aldo/keto reductase family. {ECO:0000305}.
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP007532 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324694 RefSeq NP_014763 312 glycerol 2-dehydrogenase (NADP(+)) GCY1

Identical Sequences to LMP007532 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007532 proteins

Reference Database Accession Length Protein Name