LIPID MAPS

LMPD ID

LMP007518

Gene ID

852825

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

stearoyl-CoA 9-desaturase

Gene Symbol

OLE1

Synonyms

MDM2

Chromosome

VII

EC Number

1.14.19.1

stearoyl-CoA 9-desaturase
Refseq ID	NP_011460
Protein GI	398364717
UniProt ID	P21147
mRNA ID	NM_001180920
Length	510
MPTSGTTIELIDDQFPKDDSASSGIVDEVDLTEANILATGLNKKAPRIVNGFGSLMGSKEMVSVEFDKKGNEKKSNLDRLLEKDNQEKEEAKTKIHISEQPWTLNNWHQHLNWLNMVLVCGMPMIGWYFALSGKVPLHLNVFLFSVFYYAVGGVSITAGYHRLWSHRSYSAHWPLRLFYAIFGCASVEGSAKWWGHSHRIHHRYTDTLRDPYDARRGLWYSHMGWMLLKPNPKYKARADITDMTDDWTIRFQHRHYILLMLLTAFVIPTLICGYFFNDYMGGLIYAGFIRVFVIQQATFCINSLAHYIGTQPFDDRRTPRDNWITAIVTFGEGYHNFHHEFPTDYRNAIKWYQYDPTKVIIYLTSLVGLAYDLKKFSQNAIEEALIQQEQKKINKKKAKINWGPVLTDLPMWDKQTFLAKSKENKGLVIISGIVHDVSGYISEHPGGETLIKTALGKDATKAFSGGVYRHSNAAQNVLADMRVAVIKESKNSAIRMASKRGEIYETGKFF

Entrez Gene ID

852825

Gene Name

stearoyl-CoA 9-desaturase

Gene Symbol

OLE1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030176	IDA:SGD	C	integral component of endoplasmic reticulum membrane
GO:0009055	IGI:SGD	F	electron carrier activity
GO:0020037	IEA:InterPro	F	heme binding
GO:0005506	IEA:InterPro	F	iron ion binding
GO:0004768	IMP:SGD	F	stearoyl-CoA 9-desaturase activity
GO:0006636	IMP:SGD	P	unsaturated fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID	Description
ko01040	Biosynthesis of unsaturated fatty acids
sce01040	Biosynthesis of unsaturated fatty acids
ko01212	Fatty acid metabolism
sce01212	Fatty acid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-5996	oleate biosynthesis
PWY3O-1801	palmitoleate biosynthesis

InterPro Annotations

Accession	Description
IPR009160	Acyl-CoA_deSatase_haem/ster-bd
IPR018506	Cytochrome b5, heme-binding site
IPR001199	Cytochrome b5-like heme/steroid binding domain
IPR005804	Fatty acid desaturase, type 1
IPR001522	Fatty acid desaturase, type 1, C-terminal
IPR015876	Fatty acid desaturase, type 1, core

Entry Information

Gene Name

stearoyl-CoA 9-desaturase

Protein Entry

ACO1_YEAST

UniProt ID

P21147

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
Cofactor	Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Domain	The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function	Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates
Function	Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates. {ECO:0000305}.
Interaction	Self; NbExp=1; IntAct=EBI-2098, EBI-2098; P25376:AGP1; NbExp=1; IntAct=EBI-2098, EBI-2357; P36076:CAB3; NbExp=1; IntAct=EBI-2098, EBI-26778; P08456:CHO1; NbExp=1; IntAct=EBI-2098, EBI-14055; P47133:EMC2; NbExp=1; IntAct=EBI-2098, EBI-25568; P10614:ERG11; NbExp=1; IntAct=EBI-2098, EBI-5127; P54781:ERG5; NbExp=1; IntAct=EBI-2098, EBI-6563; P54837:ERV25; NbExp=1; IntAct=EBI-2098, EBI-6642; P19145:GAP1; NbExp=1; IntAct=EBI-2098, EBI-7314; Q04697:GSF2; NbExp=1; IntAct=EBI-2098, EBI-27807; P40540:KRE27; NbExp=1; IntAct=EBI-2098, EBI-24977; P36027:MID2; NbExp=1; IntAct=EBI-2098, EBI-10901; P41543:OST1; NbExp=1; IntAct=EBI-2098, EBI-12651; Q12746:PGA3; NbExp=1; IntAct=EBI-2098, EBI-27973; P25297:PHO84; NbExp=1; IntAct=EBI-2098, EBI-13320; P38264:PHO88; NbExp=1; IntAct=EBI-2098, EBI-13350; P40975:PMP2; NbExp=1; IntAct=EBI-2098, EBI-2043041; P26570:PPZ1; NbExp=1; IntAct=EBI-2098, EBI-13807; Q04947:RTN1; NbExp=1; IntAct=EBI-2098, EBI-38020; P32368:SAC1; NbExp=1; IntAct=EBI-2098, EBI-16210; P14906:SEC63; NbExp=1; IntAct=EBI-2098, EBI-16636; P39986:SPF1; NbExp=1; IntAct=EBI-2098, EBI-3128; Q12256:TPO4; NbExp=1; IntAct=EBI-2098, EBI-37213; P25037:UBP1; NbExp=1; IntAct=EBI-2098, EBI-19819; P40107:VRG4; NbExp=1; IntAct=EBI-2098, EBI-7764; Q03362:YDR476C; NbExp=1; IntAct=EBI-2098, EBI-2057915; P35723:YET1; NbExp=1; IntAct=EBI-2098, EBI-26730;
Similarity	Belongs to the fatty acid desaturase family
Similarity	Belongs to the fatty acid desaturase family. {ECO:0000305}.
Similarity	Contains 1 cytochrome b5 heme-binding domain
Similarity	Contains 1 cytochrome b5 heme-binding domain. {ECO:0000255\|PROSITE-ProRule:PRU00279}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein .
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.