LIPID MAPS

LMPD ID

LMP007498

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Tgl1p

Gene Symbol

TGL1

Synonyms

YKL5

Chromosome

XI

EC Number

3.1.1.13

Tgl1p
Refseq ID	NP_012782
Protein GI	6322709
UniProt ID	P34163
mRNA ID	NM_001179706
Length	548
MYFPFLGRLSITDYIIVVLVYIESIISSVLKLIPQPMINLFEWLINFSTSSDDNTIEEKLRSAPTIHEMCAIFDISVEDHLVRTEDNYILTLHRIPPISKNRFNNKVVYLHHGLLMCSDVWCCNIERHKNLPFVLHDLGYDVWMGNNRGNKYSTAHLNKPPKSNKFWDFSIDEFAFFDIPNSIEFILDITKVDKVICIGFSQGSAQMFAAFSLSEKLNRKVSHFIAIAPAMTPKGLHNRIVDTLAKSSPGFMYLFFGRKIVLPSAVIWQRTLHPTLFNLCIDIANKILFNWKSFNILPRQKIASYAKLYSTTSVKSIVHWFQILRSQKFQMFEESDNMLNSLTRPYQIANFPTRTNIKIPILLIYGGIDSLVDIDVMKKNLPFNSVFDVKVDNYEHLDLIWGKDADTLVIAKVLRFIEFFNPGNVSVKTNQLLPSASLVEELPSTTWKTTHPTHGLSYRTHSADRSPLSVQADEADEVHNADNSRFLRRVFSTSAIDEDNENEHQDDTEDQIHKEQQRRLSAYLESSKDLRQLDANSSTTALDALNKE

Entrez Gene ID

Gene Name

Tgl1p

Gene Symbol

TGL1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0016021	IDA:SGD	C	integral component of membrane
GO:0005811	IDA:SGD	C	lipid particle
GO:0016298	ISS:SGD	F	lipase activity
GO:0004771	IDA:SGD	F	sterol esterase activity
GO:0044255	IMP:SGD	P	cellular lipid metabolic process
GO:0016042	IEA:UniProtKB-KW	P	lipid catabolic process
GO:0016125	IMP:SGD	P	sterol metabolic process

BIOCYC Pathway ID	Description
PWY-7424	sterol:steryl ester interconversion
PWY-7424	sterol:steryl ester interconversion (yeast)
LIPAS-PWY	triacylglycerol degradation
LIPAS-PWY	triacylglycerol degradation

Accession	Description
IPR029058	Alpha/Beta hydrolase fold
IPR000073	Alpha/beta hydrolase fold-1
IPR006693	Partial AB-hydrolase lipase domain

Gene Name

Tgl1p

Protein Entry

TGL1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	A steryl ester + H(2)O = a sterol + a fatty acid.
Function	Mediates the hydrolysis of steryl esters. Required for mobilization of steryl ester, thereby playing a central role in lipid metabolism. May have weak lipase activity toward triglycerides upon some conditions, however, the relevance of such activity is unclear in vivo. {ECO:0000269\|PubMed:10515935, ECO:0000269\|PubMed:14640980, ECO:0000269\|PubMed:15713625, ECO:0000269\|PubMed:15922657}.
Miscellaneous	Present with 1470 molecules/cell in log phase SD medium
Miscellaneous	Present with 1470 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Ptm	Not N-glycosylated.
Similarity	Belongs to the AB hydrolase superfamily
Similarity	Belongs to the AB hydrolase superfamily. {ECO:0000305}.
Subcellular Location	Membrane; Single-pass type III membrane protein. Lipid droplet.