Gene/Proteome Database (LMPD)

LMPD ID
LMP007484
Gene ID
850441
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
type 2C protein phosphatase PTC6
Gene Symbol
PTC6
Synonyms
AUP1; PPP2
Alternate Names
type 2C protein phosphatase PTC6
Chromosome
III
EC Number
3.1.3.43

Proteins

type 2C protein phosphatase PTC6
Refseq ID NP_010003
Protein GI 10383808
UniProt ID P25646
mRNA ID NM_001180034
Length 442
RefSeq Status PROVISIONAL
MRLGNAYAYCKPSQNVGLKLDLLRGLPGYVGHATSRINRLENQDNYSIKMMRSWPNAYGSALNCSVFDGHGEKGAQLSQLLADKLCSSLDFPEPSWDKQDLKKLVQEYARRFPEGNYWKHKLSTFEKFYNKFIKNCNSKQELLLMKEGDSAILGQNGGRMIFDKMGNIIDKIALLTELDRLRLFYGFARFDLDQCCGLGTAAGSTASSIFLYPYDDPNAPIDEGKDDDSWIISHSGLLKLIVTQVGDSKIILCDQDGIAHALTTTHHINSSRERHRLSIDPSRLDPDAFGETRFLNNFANTRSFGDVAGKPYGISSEPDIFSFLVGNTLHLPRSERSKLPFNGDECFLALVTDGITNKLADQEVVDLITSTVNSWGLKKATPQFVAEETIKFIQAIATKHSDNATCVVVRLSNWGNWPNVDRTGPQRETKLMNAQSNETKLN

Gene Information

Entrez Gene ID
850441
Gene Name
type 2C protein phosphatase PTC6
Gene Symbol
PTC6
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005758 IDA:SGD C mitochondrial intermembrane space
GO:0005759 IDA:SGD C mitochondrial matrix
GO:0004741 IEA:UniProtKB-EC F [pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0004722 IDA:SGD F protein serine/threonine phosphatase activity
GO:0016236 IGI:SGD P macroautophagy
GO:0000422 IMP:SGD P mitochondrion degradation
GO:0043085 IMP:SGD P positive regulation of catalytic activity
GO:0006470 IMP:SGD P protein dephosphorylation

Domain Information

InterPro Annotations

Accession Description
IPR015655 Protein phosphatase 2C
IPR001932 Protein phosphatase 2C (PP2C)-like domain

UniProt Annotations

Entry Information

Gene Name
type 2C protein phosphatase PTC6
Protein Entry
PDP2_YEAST
UniProt ID
P25646
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity [Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.
Disruption Phenotype Confers rapamycin-sensitivity. {ECO:0000269|PubMed:17002782}.
Function Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex. Required for efficient mitophagy in stationary phase cells. {ECO:0000269|PubMed:17002782, ECO:0000269|PubMed:17166847, ECO:0000269|PubMed:18180296}.
Miscellaneous Present with 432 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Contains 1 PP2C-like domain. {ECO:0000305}.
Subcellular Location Mitochondrion intermembrane space. Mitochondrion matrix.
Subunit Interacts with PRO2. {ECO:0000269|Ref.4}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007484 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10383808 RefSeq NP_010003 442 type 2C protein phosphatase PTC6

Identical Sequences to LMP007484 proteins

Reference Database Accession Length Protein Name
GI:10383808 DBBJ GAA21981.1 442 K7_Ptc6p [Saccharomyces cerevisiae Kyokai no. 7]
GI:10383808 GenBank EGA63138.1 442 Ptc6p [Saccharomyces cerevisiae FostersO]
GI:10383808 GenBank EIW11810.1 442 Ptc6p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:10383808 GenBank EWG97309.1 442 Ptc6p [Saccharomyces cerevisiae R103]
GI:10383808 GenBank AHN96137.1 442 PTC6 [synthetic construct]
GI:10383808 GenBank AHV79339.1 442 PTC6 [synthetic construct]

Related Sequences to LMP007484 proteins

Reference Database Accession Length Protein Name
GI:10383808 GenBank EEU05404.1 442 Ptc6p [Saccharomyces cerevisiae JAY291]
GI:10383808 GenBank EGA59585.1 442 Ptc6p [Saccharomyces cerevisiae FostersB]
GI:10383808 GenBank EWG87473.1 442 Ptc6p [Saccharomyces cerevisiae R008]
GI:10383808 GenBank EWG92276.1 442 Ptc6p [Saccharomyces cerevisiae P301]
GI:10383808 GenBank EWH19314.1 442 Ptc6p [Saccharomyces cerevisiae P283]
GI:10383808 gnl McCuskerlabDuke 442 Ptc6p [Saccharomyces cerevisiae YJM993]