LIPID MAPS

LMPD ID

LMP007463

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

NADH-ubiquinone reductase (H(+)-translocating) NDI1

Gene Symbol

NDI1

Synonyms

-

Chromosome

XIII

EC Number

1.6.5.9

NADH-ubiquinone reductase (H(+)-translocating) NDI1
Refseq ID	NP_013586
Protein GI	6323515
UniProt ID	P32340
mRNA ID	NM_001182483
Length	513
MLSKNLYSNKRLLTSTNTLVRFASTRSTGVENSGAGPTSFKTMKVIDPQHSDKPNVLILGSGWGAISFLKHIDTKKYNVSIISPRSYFLFTPLLPSAPVGTVDEKSIIEPIVNFALKKKGNVTYYEAEATSINPDRNTVTIKSLSAVSQLYQPENHLGLHQAEPAEIKYDYLISAVGAEPNTFGIPGVTDYGHFLKEIPNSLEIRRTFAANLEKANLLPKGDPERRRLLSIVVVGGGPTGVEAAGELQDYVHQDLRKFLPALAEEVQIHLVEALPIVLNMFEKKLSSYAQSHLENTSIKVHLRTAVAKVEEKQLLAKTKHEDGKITEETIPYGTLIWATGNKARPVITDLFKKIPEQNSSKRGLAVNDFLQVKGSNNIFAIGDNAFAGLPPTAQVAHQEAEYLAKNFDKMAQIPNFQKNLSSRKDKIDLLFEENNFKPFKYNDLGALAYLGSERAIATIRSGKRTFYTGGGLMTFYLWRILYLSMILSARSRLKVFFDWIKLAFFKRDFFKGL

Entrez Gene ID

Gene Name

NADH-ubiquinone reductase (H(+)-translocating) NDI1

Gene Symbol

NDI1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005743	IEA:UniProtKB-KW	C	mitochondrial inner membrane
GO:0005759	IDA:SGD	C	mitochondrial matrix
GO:0005739	IDA:SGD	C	mitochondrion
GO:0008137	IDA:SGD	F	NADH dehydrogenase (ubiquinone) activity
GO:0050660	IEA:InterPro	F	flavin adenine dinucleotide binding
GO:0006116	IDA:SGD	P	NADH oxidation
GO:0001300	IMP:SGD	P	chronological cell aging
GO:0006120	IDA:SGD	P	mitochondrial electron transport, NADH to ubiquinone
GO:0043065	IMP:SGD	P	positive regulation of apoptotic process

BIOCYC Pathway ID	Description
PWY-7269-YEAST	NAD/NADP-NADH/NADPH mitochondrial interconversion
PWY-7269	NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
PWY-7279-YEAST	aerobic respiration (cytochrome c)
PWY-7279	aerobic respiration (cytochrome c) (yeast)
PWY3O-188	aerobic respiration (linear view)
PWY-7245	superpathway NAD/NADP - NADH/NADPH interconversion
PWY-7245	superpathway NAD/NADP - NADH/NADPH interconversion (yeast)

Accession	Description
IPR013027	FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR023753	Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
IPR001327	Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain

Gene Name

NADH-ubiquinone reductase (H(+)-translocating) NDI1

Protein Entry

NDI1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	NADH + ubiquinone = NAD(+) + ubiquinol.
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ; Note=Binds 1 FAD per subunit. ;
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; Note=Binds 1 FAD per subunit. {ECO:0000250};
Function	Catalyzes the oxidation of NADH generated inside the Mitochondrion.
Interaction	P10614:ERG11; NbExp=1; IntAct=EBI-11961, EBI-5127;
Miscellaneous	Present with 5240 molecules/cell in log phase SD medium
Miscellaneous	Present with 5240 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the NADH dehydrogenase family
Similarity	Belongs to the NADH dehydrogenase family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side . Note=Bound to the mitochondrial inner membrane facing the matrix site.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:11502169}; Peripheral membrane protein {ECO:0000269\|PubMed:11502169}; Matrix side {ECO:0000269\|PubMed:11502169}. Note=Bound to the mitochondrial inner membrane facing the matrix site.