Gene/Proteome Database (LMPD)

LMPD ID
LMP007447
Gene ID
851539
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1
Gene Symbol
GPD1
Synonyms
DAR1; HOR1; OSG1; OSR5
Chromosome
IV
EC Number
1.1.1.8;

Proteins

glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1
Refseq ID NP_010262
Protein GI 6320181
UniProt ID Q00055
mRNA ID NM_001180081
Length 391
MSAAADRLNLTSGHLNAGRKRSSSSVSLKAAEKPFKVTVIGSGNWGTTIAKVVAENCKGYPEVFAPIVQMWVFEEEINGEKLTEIINTRHQNVKYLPGITLPDNLVANPDLIDSVKDVDIIVFNIPHQFLPRICSQLKGHVDSHVRAISCLKGFEVGAKGVQLLSSYITEELGIQCGALSGANIATEVAQEHWSETTVAYHIPKDFRGEGKDVDHKVLKALFHRPYFHVSVIEDVAGISICGALKNVVALGCGFVEGLGWGNNASAAIQRVGLGEIIRFGQMFFPESREETYYQESAGVADLITTCAGGRNVKVARLMATSGKDAWECEKELLNGQSAQGLITCKEVHEWLETCGSVEDFPLFEAVYQIVYNNYPMKNLPDMIEELDLHED

Gene Information

Entrez Gene ID
851539
Gene Name
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1
Gene Symbol
GPD1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:SGD C cytosol
GO:0009331 IEA:InterPro C glycerol-3-phosphate dehydrogenase complex
GO:0005634 IDA:SGD C nucleus
GO:0005777 IDA:SGD C peroxisome
GO:0051287 IEA:InterPro F NAD binding
GO:0004367 IMP:SGD F glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0006116 IMP:SGD P NADH oxidation
GO:0005975 IEA:InterPro P carbohydrate metabolic process
GO:0046168 IEA:InterPro P glycerol-3-phosphate catabolic process
GO:0006973 IMP:SGD P intracellular accumulation of glycerol

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
sce00564 Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7385 1,3-propanediol biosynthesis (engineered)
PWY3O-48 glycerol biosynthesis
PWY-6118 glycerol-3-phosphate shuttle
PWY-6118-YEAST glycerol-3-phosphate shuttle
PWY3O-6499 phosphatidate biosynthesis II (the glycerol-3-phosphate pathway)
PWY-7411 superpathway phosphatidate biosynthesis (yeast)
PWY-7411 superpathway phosphatidate biosynthesis (yeast)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618090 Fatty acid, triacylglycerol, and ketone body metabolism
5618125 Glycerophospholipid biosynthesis
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618126 Phospholipid metabolism
5618124 Synthesis of PA
5618115 Triglyceride Biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1
Protein Entry
GPD1_YEAST
UniProt ID
Q00055
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Caution Was originally thought to be GUT2, the FAD-dependent glycerol-3-phosphate dehydrogenase
Caution Was originally thought to be GUT2, the FAD-dependent glycerol-3-phosphate dehydrogenase. {ECO:0000305|PubMed:1676389}.
Function Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells
Function Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells. {ECO:0000269|PubMed:8196651}.
Induction By osmotic stress and by methylglyoxal in a HOG pathway-dependent manner. {ECO:0000269|PubMed:15773992, ECO:0000269|PubMed:8196651}.
Miscellaneous Present with 807 molecules/cell in log phase SD medium
Miscellaneous Present with 807 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family
Similarity Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}.
Subcellular Location Cytoplasm. Peroxisome.

Identical and Related Proteins

Unique RefSeq proteins for LMP007447 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320181 RefSeq NP_010262 391 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1

Identical Sequences to LMP007447 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007447 proteins

Reference Database Accession Length Protein Name