Gene/Proteome Database (LMPD)

LMPD ID
LMP007439
Gene ID
851680
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Ste5p
Gene Symbol
STE5
Synonyms
HMD3; NUL3
Alternate Names
Ste5p
Chromosome
IV

Proteins

Ste5p
Refseq ID NP_010388
Protein GI 6320308
UniProt ID P32917
mRNA ID NM_001180411
Length 917
RefSeq Status PROVISIONAL
MMETPTDNIVSPFHNFGSSTQYSGTLSRTPNQIIELEKPSTLSPLSRGKKWTEKLARFQRSSAKKKRFSPSPISSSTFSFSPKSRVTSSNSSGNEDGNLMNTPSTVSTDYLPQHPHRTSSLPRPNSNLFHASNSNLSRANEPPRAENLSDNIPPKVAPFGYPIQRTSIKKSFLNASCTLCDEPISNRRKGEKIIELACGHLSHQECLIISFGTTSKADVRALFPFCTKCKKDTNKAVQCIPENDELKDILISDFLIHKIPDSELSITPQSRFPPYSPLLPPFGLSYTPVERQTIYSQAPSLNPNLILAAPPKERNQIPQKKSNYTFLHSPLGHRRIPSGANSILADTSVALSANDSISAVSNSVRAKDDETKTTLPLLRSYFIQILLNNFQEELQDWRIDGDYGLLRLVDKLMISKDGQRYIQCWCFLFEDAFVIAEVDNDVDVLEIRLKNLEVFTPIANLRMTTLEASVLKCTLNKQHCADLSDLYIVQNINSDESTTVQKWISGILNQDFVFNEDNITSTLPILPIIKNFSKDVGNGRHETSTFLGLINPNKVVEVGNVHDNDTVIIRRGFTLNSGECSRQSTVDSIQSVLTTISSILSLKREKPDNLAIILQIDFTKLKEEDSLIVVYNSLKALTIKFARLQFCFVDRNNYVLDYGSVLHKIDSLDSISNLKSKSSSTQFSPIWLKNTLYPENIHEHLGIVAVSNSNMEAKKSILFQDYRCFTSFGRRRPNELKIKVGYLNVDYSDKIDELVEASSWTFVLETLCYSFGLSFDEHDDDDEEDNDDSTDNELDNSSGSLSDAESTTTIHIDSPFDNENATANMVNDRNLLTEGEHSNIENLETVASSVQPALIPNIRFSLHSEEEGTNENENENDMPVLLLSDMDKGIDGITRRSSFSSLIESGNNNCPLHMDYI

Gene Information

Entrez Gene ID
851680
Gene Name
Ste5p
Gene Symbol
STE5
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:SGD C cytoplasm
GO:0043332 IDA:SGD C mating projection tip
GO:0005634 IDA:SGD C nucleus
GO:0005886 IDA:SGD C plasma membrane
GO:0005078 IPI:SGD F MAP-kinase scaffold activity
GO:0005546 IDA:SGD F phosphatidylinositol-4,5-bisphosphate binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0001403 IMP:SGD P invasive growth in response to glucose limitation
GO:0043409 IMP:SGD P negative regulation of MAPK cascade
GO:0000750 IDA:SGD P pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0001934 IDA:SGD P positive regulation of protein phosphorylation
GO:0009967 IPI:GOC P positive regulation of signal transduction
GO:0010525 IMP:SGD P regulation of transposition, RNA-mediated

KEGG Pathway Links

KEGG Pathway ID Description
ko04011 MAPK signaling pathway - yeast
sce04011 MAPK signaling pathway - yeast

Domain Information

InterPro Annotations

Accession Description
IPR021106 Protein Ste5, Fus3-binding
IPR021651 Scaffold protein Ste5, Fus5-binding domain
IPR001841 Zinc finger, RING-type

UniProt Annotations

Entry Information

Gene Name
Ste5p
Protein Entry
STE5_YEAST
UniProt ID
P32917
Species
Yeast (S288c)

Comments

Comment Type Description
Function Component of the pheromone signal transduction pathway. It mediates pheromone signals acting between STE20 and STE11. It is absolutely required for pheromone-induced transcription of FUS1. May play a role in cell-cycle arrest in response to pheromone.
Interaction Q6FPF2:CAGL0J04290g (xeno); NbExp=2; IntAct=EBI-18373, EBI-8783845; Q5A1D3:CEK1 (xeno); NbExp=2; IntAct=EBI-18373, EBI-8783371; Q5A281:CEK2 (xeno); NbExp=2; IntAct=EBI-18373, EBI-8785242; P11710:FUS1; NbExp=2; IntAct=EBI-18373, EBI-7179; P16892:FUS3; NbExp=10; IntAct=EBI-18373, EBI-7193; Q6CNR3:KLLA0E10539g (xeno); NbExp=2; IntAct=EBI-18373, EBI-8785667; C8V7D1:mpkB (xeno); NbExp=2; IntAct=EBI-18373, EBI-8783425; P23561:STE11; NbExp=7; IntAct=EBI-18373, EBI-18259; P18851:STE4; NbExp=2; IntAct=EBI-18373, EBI-7390; P06784:STE7; NbExp=8; IntAct=EBI-18373, EBI-18389;
Miscellaneous Present with 1900 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Ptm May be regulated at the phosphorylation level, and by the mating type of the cell and depends on an intact pheromone- response pathway. {ECO:0000269|PubMed:17330950}.
Similarity To yeast FAR1. {ECO:0000305}.
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP007439 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320308 RefSeq NP_010388 917 Ste5p

Identical Sequences to LMP007439 proteins

Reference Database Accession Length Protein Name
GI:6320308 GenBank ABZ27693.1 917 Sequence 1631 from patent US 7314974
GI:6320308 GenBank EDV08201.1 917 protein STE5 [Saccharomyces cerevisiae RM11-1a]
GI:6320308 GenBank EDZ73141.1 917 YDR103Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:6320308 GenBank AGD78547.1 917 Sequence 130 from patent US 8357527
GI:6320308 GenBank EWG97069.1 917 Ste5p [Saccharomyces cerevisiae R103]
GI:6320308 Third Party Genbank DAA11949.1 917 TPA: Ste5p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007439 proteins

Reference Database Accession Length Protein Name
GI:6320308 DBBJ BAA02301.1 917 a component of the pheromone signal transduction pathway [Saccharomyces cerevisiae]
GI:6320308 EMBL CAY78608.1 917 Ste5p [Saccharomyces cerevisiae EC1118]
GI:6320308 GenBank EHN08093.1 916 Ste5p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6320308 GenBank AGD78491.1 917 Sequence 18 from patent US 8357527
GI:6320308 GenBank AGD78505.1 917 Sequence 46 from patent US 8357527
GI:6320308 gnl McCuskerlabDuke 917 Ste5p [Saccharomyces cerevisiae YJM993]