LIPID MAPS

LMPD ID

LMP007421

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Pfa3p

Gene Symbol

PFA3

Synonyms

-

Chromosome

XIV

EC Number

2.3.1.225

Pfa3p
Refseq ID	NP_014073
Protein GI	6324003
UniProt ID	P42836
mRNA ID	NM_001183164
Length	336
MNDRLSLTSLFPRCLTTCLYIWTAYITLTRIHQIPRWFLALTIVPTLAVALYTYYKVIARGPGSPLDFPDLLVHDLKAAENGLELPPEYMSKRCLTLKHDGRFRVCQVCHVWKPDRCHHCSSCDVCILKMDHHCPWFAECTGFRNQKFFIQFLMYTTLYAFLVLIYTCYELGTWFNSGSFNRELIDFHLLGVALLAVAVFISVLAFTCFSIYQVCKNQTTIEVHGMRRYRRDLEILNDSYGTNEHLENIFDLGSSMANWQDIMGTSWLEWILPIETFKYKKSKHTKDEKGLYFNVRPQVQDRLLSSRCLEDQLLRRVTPRPSLEADRASVEIIDAN

Entrez Gene ID

Gene Name

Pfa3p

Gene Symbol

PFA3

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0000324	IDA:SGD	C	fungal-type vacuole
GO:0000329	IDA:SGD	C	fungal-type vacuole membrane
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005774	IDA:UniProt	C	vacuolar membrane
GO:0016409	IDA:SGD	F	palmitoyltransferase activity
GO:0019706	IEA:UniProtKB-EC	F	protein-cysteine S-palmitoyltransferase activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0018345	IDA:SGD	P	protein palmitoylation
GO:0042144	IMP:SGD	P	vacuole fusion, non-autophagic

Accession	Description
IPR001594	Zinc finger, DHHC-type, palmitoyltransferase

Gene Name

Pfa3p

Protein Entry

PFA3_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain	The DHHC domain is required for palmitoyltransferase activity.
Function	Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization
Function	Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization. {ECO:0000269\|PubMed:16186255}.
Miscellaneous	Present with 2133 molecules/cell in log phase SD medium
Miscellaneous	Present with 2133 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Ptm	Autopalmitoylated.
Similarity	Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily
Similarity	Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily. {ECO:0000305}.
Similarity	Contains 1 DHHC-type zinc finger
Similarity	Contains 1 DHHC-type zinc finger. {ECO:0000255\|PROSITE-ProRule:PRU00067}.
Subcellular Location	Vacuole membrane ; Multi- pass membrane protein {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:16186255}.
Subcellular Location	Vacuole membrane {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:16186255}; Multi- pass membrane protein {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:16186255}.