LIPID MAPS

LMPD ID

LMP007418

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

type 2C protein phosphatase PTC3

Gene Symbol

PTC3

Synonyms

-

Chromosome

II

EC Number

3.1.3.16;

type 2C protein phosphatase PTC3
Refseq ID	NP_009497
Protein GI	330443415
UniProt ID	P34221
mRNA ID	NM_001178296
Length	468
MGQILSNPIIDKEHHSGTDCLTAFGLCAMQGWRMSMEDAHIVEPNLLAESDEEHLAFYGIFDGHGGSSVAEFCGSKMISILKKQESFKSGMLEQCLIDTFLATDVELLKDEKLKDDHSGCTATVILVSQLKKLLICANSGDSRTVLSTGGNSKAMSFDHKPTLLSEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNTKLGPHEQVVTCVPDIICHNLNYDEDEFVILACDGIWDCLTSQECVDLVHYGISQGNMTLSDISSRIVDVCCSPTTEGSGIGCDNMSISIVALLKENESESQWFERMRSKNYNIQTSFVQRRKSIFDFHDFSDDDNEVFAITTKKLQDRLNRSKDNDDMEIDDLDTELGSSATPSKLSGEDRTGPIDLFSLEALLEAGIQIRQRPSSDSDGNTSYFHGASLSDMLASLSNAAAGETEPNDADDNDDNDGEENGKNENAKKGSKIEEIE

Entrez Gene ID

Gene Name

type 2C protein phosphatase PTC3

Gene Symbol

PTC3

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005737	IEA:UniProtKB-KW	C	cytoplasm
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0004722	IDA:SGD	F	protein serine/threonine phosphatase activity
GO:0000173	IGI:SGD	P	inactivation of MAPK activity involved in osmosensory signaling pathway
GO:0006470	IDA:SGD	P	protein dephosphorylation
GO:0000079	IMP:SGD	P	regulation of cyclin-dependent protein serine/threonine kinase activity

Accession	Description
IPR015655	Protein phosphatase 2C
IPR001932	Protein phosphatase 2C (PP2C)-like domain
IPR000222	Protein phosphatase 2C, manganese/magnesium aspartate binding site

Gene Name

type 2C protein phosphatase PTC3

Protein Entry

PP2C3_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 magnesium or manganese ions per subunit. ;
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
Function	Responsible, together with PTC2, for the dephosphorylation of the cyclin-dependent protein kinase CDC28
Function	Responsible, together with PTC2, for the dephosphorylation of the cyclin-dependent protein kinase CDC28. {ECO:0000269\|PubMed:10580002}.
Interaction	Q12447:PAA1; NbExp=6; IntAct=EBI-12805, EBI-33397;
Miscellaneous	Present with 19700 molecules/cell in log phase SD medium
Miscellaneous	Present with 19700 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the PP2C family
Similarity	Belongs to the PP2C family. {ECO:0000305}.
Subcellular Location	Cytoplasm . Nucleus .
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:14562095}. Nucleus {ECO:0000269\|PubMed:14562095}.