Gene/Proteome Database (LMPD)

LMPD ID
LMP007409
Gene ID
850788
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
lysophosphatidic acid acyltransferase ICT1
Gene Symbol
ICT1
Synonyms
-
Chromosome
XII
EC Number
2.3.1.51

Proteins

lysophosphatidic acid acyltransferase ICT1
Refseq ID NP_013200
Protein GI 6323128
UniProt ID Q12385
mRNA ID NM_001181986
Length 394
MWTNTFKWCSKTEKETTTADAKVCASVQGLKALQQQIMDSTTVRGSVNNTMTPGGINQWHFHNKRANKVCTPTVLIHGYAASSMAFYRTFENLSDNIKDLYAIDLPANGASEAPALQVNKTKKIKSLRFKHIEDDVVIPVIEKRPPAEDIKSHLEQYESYFVDRIEQWRKDNKLRKINVVGHSFGGYISFKYALKYPDSIEKLCLISPLGVENSIHAITHKWEPNTTYPLTFTDPSSRYYTRKLNVPRFIFENQLNVLKWMGPIGSKLCSNYISTAYVKVPDQIYKDYLLHSFVGKNQTVQPQTIKVFTHLFERNLIARDPIINNVRFLNPATPVMFMYGEHDWMDKYAGYLTTESMLKNKAKASYVEVPDAGHNLFLDNPQHFASSLVSFLSK

Gene Information

Entrez Gene ID
850788
Gene Name
lysophosphatidic acid acyltransferase ICT1
Gene Symbol
ICT1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0003841 IEA:UniProtKB-EC F 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0042171 IDA:SGD F lysophosphatidic acid acyltransferase activity
GO:0006654 IMP:SGD P phosphatidic acid biosynthetic process
GO:0006950 IEA:UniProtKB-KW P response to stress

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR000073 Alpha/beta hydrolase fold-1

UniProt Annotations

Entry Information

Gene Name
lysophosphatidic acid acyltransferase ICT1
Protein Entry
ICT1_YEAST
UniProt ID
Q12385
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
Function Lysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper. {ECO:0000269|PubMed:10628851, ECO:0000269|PubMed:11055939, ECO:0000269|PubMed:18252723, ECO:0000269|PubMed:9717239}.
Miscellaneous The isooctane tolerance of organic-solvent tolerant strain KK-21 may result from the alteration of the expression of several genes including ICT1, due to the loss of their proper regulation.
Similarity Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily
Similarity Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007409 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323128 RefSeq NP_013200 394 lysophosphatidic acid acyltransferase ICT1

Identical Sequences to LMP007409 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007409 proteins

Reference Database Accession Length Protein Name