Gene/Proteome Database (LMPD)

LMPD ID
LMP007400
Gene ID
855029
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
C-22 sterol desaturase
Gene Symbol
ERG5
Synonyms
CYP61
Chromosome
XIII
EC Number
1.14.-.-

Proteins

C-22 sterol desaturase
Refseq ID NP_013728
Protein GI 6323657
UniProt ID P54781
mRNA ID NM_001182511
Length 538
MSSVAENIIQHATHNSTLHQLAKDQPSVGVTTAFSILDTLKSMSYLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWPIIGPFLESLDPKFEEYKAKWASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHTDYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALSLNSFCGNYITEDQVRKIADDYYLVTAALELVNFPIIIPYTKTWYGKKTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFALYTDFHHTVTPLSEKIKVFATIFPKDDLLLTFKKRDPITGEVFE

Gene Information

Entrez Gene ID
855029
Gene Name
C-22 sterol desaturase
Gene Symbol
ERG5
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000249 IDA:SGD F C-22 sterol desaturase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:InterPro F monooxygenase activity
GO:0006696 IDA:SGD P ergosterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
M00102 Ergocalciferol biosynthesis
sce_M00102 Ergocalciferol biosynthesis
sce01100 Metabolic pathways
ko00100 Steroid biosynthesis
sce00100 Steroid biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6075 ergosterol biosynthesis
PWY-6075 ergosterol biosynthesis I
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis I

REACTOME Pathway Links

REACTOME Pathway ID Description
5618031 Biological oxidations
5618362 Cytochrome P450 - arranged by substrate type
5618023 Metabolism
5618064 Phase 1 - Functionalization of compounds
5618443 Vitamins

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
C-22 sterol desaturase
Protein Entry
ERG5_YEAST
UniProt ID
P54781
Species
Yeast (S288c)

Comments

Comment Type Description
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Required to form the C-22(23) double bond in the sterol side chain.
Miscellaneous Present with 24700 molecules/cell in log phase SD medium
Miscellaneous Present with 24700 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 4/5.
Similarity Belongs to the cytochrome P450 family
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subunit Interacts with ERG28
Subunit Interacts with ERG28. {ECO:0000269|PubMed:15995173}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007400 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323657 RefSeq NP_013728 538 C-22 sterol desaturase

Identical Sequences to LMP007400 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007400 proteins

Reference Database Accession Length Protein Name