Gene/Proteome Database (LMPD)

LMPD ID
LMP007399
Gene ID
850334
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Kcc4p
Gene Symbol
KCC4
Synonyms
-
Alternate Names
Kcc4p
Chromosome
III
EC Number
2.7.11.1

Proteins

Kcc4p
Refseq ID NP_009907
Protein GI 10383767
UniProt ID P25389
mRNA ID NM_001178670
Length 1037
RefSeq Status PROVISIONAL
MTVANTETHSAAKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLLKKYQTIKDSKSIKDLPRENTYLYPLADSNNHTSASIDDSILQNLVVLWHGRHADDIVSKLKENGTNKEKILYALLYRFKLDSVRGSNKKNRNKIKKTKKNKRSSTLSSSSSLLLNNRSIQSTPRRRTSKRHSREFSSSRKRSSFLLSSNPTDSSPIPLRSSKRITHINVASANTQATPSGVPNPHKRNSKKRSSKRLSYMPNTKRSSLTSKSLSNFTNLIDDDDWEYIEKDAKRTSSNFATLIDEIFEPEKFELAKREKAELQRKVQEAKRQSVNAQKINEDEFGSEVSDGMKELKKINDKVSSPLINYEFSQQELLQDIDTLLTNRYQLSSYTRPISRLDPGLTPVTETLPNNLKEKTALLQDTEKKIIETIRRSKFLGSLLNVRGGLSPGKSELAPIEESPIVSTTPLIYNDRMEPRRISDVEVPHFTRKSKHFTTANNRRSVLSLYAKDSIKDLNEFLIKEDPDLPPQGSTDNESRSEDPEIAESITDSRNIQYDEDDSKDGDNVNNDNILSDFPQGVGISQEYDMKDKNPNQSPISKSAEPTLVVKLPSLSSFQGKNASGLGLYQREPSKVTLPSLTSNNSSVGENIEDGAEKGTESEKIAASLSDDDLKEDNDKKDNDTVNAPTTVKKPPNSVLLKKFSKGKILELEIHAKIPEKRLYEGLHKLLEGWKQYGLKNLVFNITNMIITGKLVNDSILFLRSTLFEIMVLPNGDGRSLIKFNKKTGSTKTLTKLATEIQIILQKEGVLDK

Gene Information

Entrez Gene ID
850334
Gene Name
Kcc4p
Gene Symbol
KCC4
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005935 IDA:SGD C cellular bud neck
GO:0032174 IDA:SGD C cellular bud neck septin collar
GO:0000131 IDA:SGD C incipient cellular bud site
GO:0005886 IDA:UniProtKB C plasma membrane
GO:0005940 IDA:SGD C septin ring
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0070300 IDA:UniProtKB F phosphatidic acid binding
GO:0005546 IDA:UniProtKB F phosphatidylinositol-4,5-bisphosphate binding
GO:0001786 IDA:UniProtKB F phosphatidylserine binding
GO:0004672 ISS:SGD F protein kinase activity
GO:0004674 IEA:UniProtKB-KW F protein serine/threonine kinase activity
GO:0007117 IMP:SGD P budding cell bud growth
GO:0031565 IMP:SGD P cytokinesis checkpoint
GO:0006468 ISS:SGD P protein phosphorylation
GO:0008360 IEA:UniProtKB-KW P regulation of cell shape
GO:0000921 IMP:SGD P septin ring assembly

Domain Information

InterPro Annotations

Accession Description
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
Kcc4p
Protein Entry
KCC4_YEAST
UniProt ID
P25389
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Function Involved in regulation of bud growth during cell cycle and in septin organization. Plays a role in cell wall synthesis. {ECO:0000269|PubMed:12773812}.
Interaction P25293:NAP1; NbExp=6; IntAct=EBI-9607, EBI-11850;
Miscellaneous Present with 538 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. {ECO:0000305}.
Similarity Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular Location Bud neck {ECO:0000269|PubMed:11165249, ECO:0000269|PubMed:9925642}.
Subunit Interacts with septin proteins, primarily with CDC11. Interacts with SWE1 and NAP1. {ECO:0000269|PubMed:11165249, ECO:0000269|PubMed:12773812, ECO:0000269|PubMed:18086883}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007399 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10383767 RefSeq NP_009907 1037 Kcc4p

Identical Sequences to LMP007399 proteins

Reference Database Accession Length Protein Name
GI:10383767 EMBL CAC42961.1 1037 kinase [Saccharomyces cerevisiae]
GI:10383767 GenBank EIW11859.1 1037 Kcc4p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:10383767 GenBank AGD13872.1 1037 Sequence 11328 from patent US 8343764
GI:10383767 GenBank AHN96039.1 1037 KCC4 [synthetic construct]
GI:10383767 SwissProt P25389.3 1037 RecName: Full=Probable serine/threonine-protein kinase KCC4 [Saccharomyces cerevisiae S288c]
GI:10383767 Third Party Genbank DAA07461.1 1037 TPA: Kcc4p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007399 proteins

Reference Database Accession Length Protein Name
GI:10383767 DBBJ GAA21895.1 1037 K7_Kcc4p [Saccharomyces cerevisiae Kyokai no. 7]
GI:10383767 EMBL CAY78182.1 1037 Kcc4p [Saccharomyces cerevisiae EC1118]
GI:10383767 GenBank EDN62105.1 1037 serine/threonine protein kinase [Saccharomyces cerevisiae YJM789]
GI:10383767 GenBank EDV09689.1 1037 hypothetical protein SCRG_05385 [Saccharomyces cerevisiae RM11-1a]
GI:10383767 GenBank EEU06083.1 1037 Kcc4p [Saccharomyces cerevisiae JAY291]
GI:10383767 gnl McCuskerlabDuke 1037 Kcc4p [Saccharomyces cerevisiae YJM993]