Gene/Proteome Database (LMPD)

LMPD ID
LMP007398
Gene ID
852883
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Gene Symbol
ERG26
Synonyms
-
Alternate Names
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Chromosome
VII
EC Number
1.1.1.170

Proteins

sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Refseq ID NP_011514
Protein GI 6321437
UniProt ID P53199
mRNA ID NM_001180866
Length 349
RefSeq Status PROVISIONAL
MSKIDSVLIIGGSGFLGLHLIQQFFDINPKPDIHIFDVRDLPEKLSKQFTFNVDDIKFHKGDLTSPDDMENAINESKANVVVHCASPMHGQNPDIYDIVNVKGTRNVIDMCKKCGVNILVYTSSAGVIFNGQDVHNADETWPIPEVPMDAYNETKAIAEDMVLKANDPSSDFYTVALRPAGIFGPGDRQLVPGLRQVAKLGQSKFQIGDNNNLFDWTYAGNVADAHVLAAQKLLDPKTRTAVSGETFFITNDTPTYFWALARTVWKADGHIDKHVIVLKRPVAICAGYLSEWVSKMLGKEPGLTPFRVKIVCAYRYHNIAKAKKLLGYTPRVGIEEGINKTLAWMDEGL

Gene Information

Entrez Gene ID
852883
Gene Name
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Gene Symbol
ERG26
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0005789 IDA:SGD C endoplasmic reticulum membrane
GO:0003854 IEA:InterPro F 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0000252 IDA:SGD F C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
GO:0047012 IEA:UniProtKB-EC F sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
GO:0006696 IDA:SGD P ergosterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00100 Steroid biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618346 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Protein Entry
ERG26_YEAST
UniProt ID
P53199
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity A 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) = a 3-oxosteroid + CO(2) + NAD(P)H.
Interaction P40030:ERG28; NbExp=3; IntAct=EBI-6514, EBI-22518; P38132:MCM7; NbExp=2; IntAct=EBI-6514, EBI-4300;
Miscellaneous Present with 2580 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.
Similarity Belongs to the 3-beta-HSD family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12119386, ECO:0000269|PubMed:15716577}; Peripheral membrane protein {ECO:0000269|PubMed:12119386, ECO:0000269|PubMed:15716577}.
Subunit Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation- related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. {ECO:0000269|PubMed:12119386}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007398 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6321437 RefSeq NP_011514 349 sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)

Identical Sequences to LMP007398 proteins

Reference Database Accession Length Protein Name
GI:6321437 GenBank EHN07120.1 349 Erg26p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6321437 GenBank EIW10353.1 349 Erg26p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6321437 GenBank EWG90993.1 349 Erg26p [Saccharomyces cerevisiae P301]
GI:6321437 GenBank EWG96099.1 349 Erg26p [Saccharomyces cerevisiae R103]
GI:6321437 GenBank EWH18269.1 349 Erg26p [Saccharomyces cerevisiae P283]
GI:6321437 gnl McCuskerlabDuke 349 Erg26p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007398 proteins

Reference Database Accession Length Protein Name
GI:6321437 DBBJ GAA23386.1 349 K7_Erg26p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6321437 EMBL CAG59317.1 349 unnamed protein product [Candida glabrata]
GI:6321437 GenBank EJS43718.1 349 erg26p [Saccharomyces arboricola H-6]
GI:6321437 GenBank EJT41730.1 349 ERG26-like protein [Saccharomyces kudriavzevii IFO 1802]
GI:6321437 GenBank EWG85900.1 349 Erg26p [Saccharomyces cerevisiae R008]
GI:6321437 RefSeq XP_446390.1 349 hypothetical protein [Candida glabrata CBS 138]