LIPID MAPS

LMPD ID

LMP007391

Gene ID

855956

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

ATP-binding cassette long-chain fatty acid transporter PXA1

Gene Symbol

PXA1

Synonyms

LPI1; PAL1; PAT2; SSH2

Alternate Names

ATP-binding cassette long-chain fatty acid transporter PXA1

Chromosome

XVI

ATP-binding cassette long-chain fatty acid transporter PXA1
Refseq ID	NP_015178
Protein GI	6325110
UniProt ID	P41909
mRNA ID	NM_001183961
Length	870
RefSeq Status	PROVISIONAL
MSTTLAAPAKLKSLLLNLHTHCIGLHVNDVTPKVYFKLLIRHLLQISRSNAAHPKLRRRAQILLVSLFLSGVTLFSGVTYSTFKIILKCYKFYKFPWKRRNRRPLIRRTRSQMQLDSGARIMYIPEVELVDRQSPDDNKFMNATDKKKRKRIFIPPKDNDVYEHDKFLFKNVELERAKNSQLFYSKFLNQMNVLSKILIPTVFDKNFLLLTAQIFFLVMRTWLSLFVAKLDGQIVKNIIAGRGRSFLWDLGCWFLIAVPASYTNSAIKLLQRKLSLNFRVNLTRYIHDMYLDKRLTFYKLIFDAKASNSVIKNIDNSITNDVAKFCDATCSVFANIAKPVIDLIFFSVYLRDNLGTVGVAGIFVNYFITGFILRKYTPPLGKLAGERSASDGDYYNYHLNMINNSEEIAFYQGTAVERTKVKELYDVLMEKMLLVDKVKFGYNMLEDYVLKYTWSGLGYVFASIPIVMSTLATGINSEEKNMKEFIVNKRLMLSLADAGSRLMHSIKDISQLTGYTNRIFTLLSVLHRVHSLNFNYGAVPSILSIRTEDASRNSNLLPTTDNSQDAIRGTIQRNFNGIRLENIDVIIPSVRASEGIKLINKLTFQIPLHIDPITSKSNSIQDLSKANDIKLPFLQGSGSSLLILGPNGCGKSSIQRIIAEIWPVYNKNGLLSIPSENNIFFIPQKPYFSRGGTLRDQIIYPMSSDEFFDRGFRDKELVQILVEVKLDYLLKRGVGLTYLDAIADWKDLLSGGEKQRVNFARIMFHKPLYVVLDEATNAISVDMEDYLFNLLKRYRFNFISISQRPTLIKYHEMLLEIGENRDGKWQLQAVGTDEAITSIDNEIEELERKLERVKGWEDERTKLREKLEII

Entrez Gene ID

855956

Gene Name

ATP-binding cassette long-chain fatty acid transporter PXA1

Gene Symbol

PXA1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005779	IDA:SGD	C	integral component of peroxisomal membrane
GO:0005777	IDA:UniProtKB	C	peroxisome
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0042626	IMP:SGD	F	ATPase activity, coupled to transmembrane movement of substances
GO:0005325	IGI:UniProtKB	F	peroxisomal fatty-acyl-CoA transporter activity
GO:0006635	IGI:UniProtKB	P	fatty acid beta-oxidation
GO:0015908	IMP:SGD	P	fatty acid transport
GO:0015916	IGI:UniProtKB	P	fatty-acyl-CoA transport
GO:0042758	IMP:UniProtKB	P	long-chain fatty acid catabolic process
GO:0015910	IGI:UniProtKB	P	peroxisomal long-chain fatty acid import
GO:0042760	IMP:UniProtKB	P	very long-chain fatty acid catabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
sce02010	ABC transporters
ko04146	Peroxisome
sce04146	Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618450	ABCA transporters in lipid homeostasis

InterPro Annotations

Accession	Description
IPR003593	AAA+ ATPase domain
IPR011527	ABC transporter type 1, transmembrane domain
IPR017871	ABC transporter, conserved site
IPR003439	ABC_transporter-like
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR005283	Peroxysomal long chain fatty acyl transporter

Entry Information

Gene Name

ATP-binding cassette long-chain fatty acid transporter PXA1

Protein Entry

PXA1_YEAST

UniProt ID

P41909

Species

Yeast (S288c)

Comments

Comment Type	Description
Function	Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269\|PubMed:8670886}.
Interaction	P34230:PXA2; NbExp=2; IntAct=EBI-14344, EBI-2464632;
Sequence Caution	Sequence=AAB68215.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC49009.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. {ECO:0000305}.
Similarity	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255\|PROSITE-ProRule:PRU00441}.
Similarity	Contains 1 ABC transporter domain. {ECO:0000255\|PROSITE-ProRule:PRU00434}.
Subcellular Location	Peroxisome membrane; Multi-pass membrane protein.
Subunit	Forms a heterodimer with PXA2.

Unique RefSeq proteins for LMP007391 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
6325110	RefSeq	NP_015178	870	ATP-binding cassette long-chain fatty acid transporter PXA1

Identical Sequences to LMP007391 proteins

Reference	Database	Accession	Length	Protein Name
GI:6325110	EMBL	CAA97852.1	870	PXA1 [Saccharomyces cerevisiae]
GI:6325110	EMBL	CAA65546.1	870	P2607 protein [Saccharomyces cerevisiae]
GI:6325110	GenBank	EIW06965.1	870	Pxa1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6325110	PRF	-	870	ATP-binding cassette transporter [Saccharomyces cerevisiae]
GI:6325110	SwissProt	P41909.2	870	RecName: Full=Peroxisomal long-chain fatty acid import protein 2; AltName: Full=Peroxisomal ABC transporter 1 [Saccharomyces cerevisiae S288c]
GI:6325110	Third Party Genbank	DAA11288.1	870	TPA: ATP-binding cassette long-chain fatty acid transporter PXA1 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007391 proteins

Reference	Database	Accession	Length	Protein Name
GI:6325110	DBBJ	GAA26829.1	870	K7_Pxa1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6325110	GenBank	EDN60999.1	870	long-chain fatty acid transporter subunit [Saccharomyces cerevisiae YJM789]
GI:6325110	GenBank	EDV11079.1	870	ABC transporter of long-chain fatty acids [Saccharomyces cerevisiae RM11-1a]
GI:6325110	GenBank	EGA84522.1	870	Pxa1p [Saccharomyces cerevisiae VL3]
GI:6325110	GenBank	EWG93055.1	870	Pxa1p [Saccharomyces cerevisiae R103]
GI:6325110	gnl	McCuskerlabDuke	870	Pxa1p [Saccharomyces cerevisiae YJM993]