LIPID MAPS

LMPD ID

LMP007390

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Pkp1p

Gene Symbol

PKP1

Synonyms

-

Chromosome

IX

EC Number

2.7.11.2

Pkp1p
Refseq ID	NP_012222
Protein GI	6322147
UniProt ID	P40530
mRNA ID	NM_001179392
Length	394
MWKIMRSWKCGGMRWAHRQRPSHELLSQLSFDQHYKIRSNIELLIQDYASKPIAPLNYEYFLQYRPPLTKKEEYMLTIKTINLLLSLTCKRLNAIQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYELHNPPKIQAKFTELLDDHEDAIVVLAKGLQEIQSCYPKFQISQFLNFHLKERITMKLLVTHYLSLMAQNKGDTNKRMIGILHRDLPIAQLIKHVSDYVNDICFVKFNTQRTPVLIHPPSQDITFTCIPPILEYIMTEVFKNAFEAQIALGKEHMPIEINLLKPDDDELYLRIRDHGGGITPEVEALMFNYSYSTHTQQSADSESTDLPGEQINNVSGMGFGLPMCKTYLELFGGKIDVQSLLGWGTDVYIKLKGPSKTALLSKK

Entrez Gene ID

Gene Name

Pkp1p

Gene Symbol

PKP1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005739	IDA:SGD	C	mitochondrion
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0004672	IDA:SGD	F	protein kinase activity
GO:0004674	IEA:UniProtKB-KW	F	protein serine/threonine kinase activity
GO:0004740	IMP:SGD	F	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0015976	IGI:SGD	P	carbon utilization
GO:0006006	IEA:UniProtKB-KW	P	glucose metabolic process
GO:0018105	IMP:SGD	P	peptidyl-serine phosphorylation
GO:0006468	IMP:SGD	P	protein phosphorylation

Accession	Description
IPR018955	Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
IPR003594	Histidine kinase-like ATPase, C-terminal domain
IPR005467	Signal transduction histidine kinase, core
IPR004358	Signal transduction histidine kinase-related protein, C-terminal

Gene Name

Pkp1p

Protein Entry

PDK1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	ATP + [pyruvate dehydrogenase (acetyl- transferring)] = ADP + [pyruvate dehydrogenase (acetyl- transferring)] phosphate.
Function	Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism. Also involved in telomere maintenance. {ECO:0000269\|PubMed:15161972, ECO:0000269\|PubMed:16643908, ECO:0000269\|PubMed:18180296}.
Interaction	P53170:PKP2; NbExp=3; IntAct=EBI-2610722, EBI-23792;
Miscellaneous	Present with 4220 molecules/cell in log phase SD medium
Miscellaneous	Present with 4220 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the PDK/BCKDK protein kinase family
Similarity	Belongs to the PDK/BCKDK protein kinase family. {ECO:0000305}.
Similarity	Contains 1 histidine kinase domain
Similarity	Contains 1 histidine kinase domain. {ECO:0000255\|PROSITE-ProRule:PRU00107}.
Subcellular Location	Mitochondrion matrix {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:16643908, ECO:0000269\|PubMed:18180296}.
Subunit	Interacts with PKP2
Subunit	Interacts with PKP2. {ECO:0000269\|PubMed:18180296}.