LIPID MAPS

LMPD ID

LMP007377

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

alpha-ketoglutarate dehydrogenase KGD1

Gene Symbol

KGD1

Synonyms

OGD1

Chromosome

IX

EC Number

1.2.4.2

alpha-ketoglutarate dehydrogenase KGD1
Refseq ID	NP_012141
Protein GI	6322066
UniProt ID	P20967
mRNA ID	NM_001179473
Length	1014
MLRFVSSQTCRYSSRGLLKTSLLKNASTVKIVGRGLATTGTDNFLSTSNATYIDEMYQAWQKDPSSVHVSWDAYFKNMSNPKIPATKAFQAPPSISNFPQGTEAAPLGTAMTGSVDENVSIHLKVQLLCRAYQVRGHLKAHIDPLGISFGSNKNNPVPPELTLDYYGFSKHDLDKEINLGPGILPRFARDGKSKMSLKEIVDHLEKLYCSSYGVQYTHIPSKQKCDWLRERIEIPEPYQYTVDQKRQILDRLTWATSFESFLSTKFPNDKRFGLEGLESVVPGIKTLVDRSVELGVEDIVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSSARDDIEGSGDVKYHLGMNYQRPTTSGKYVNLSLVANPSHLESQDPVVLGRTRALLHAKNDLKEKTKALGVLLHGDAAFAGQGVVYETMGFLTLPEYSTGGTIHVITNNQIGFTTDPRFARSTPYPSDLAKAIDAPIFHVNANDVEAVTFIFNLAAEWRHKFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYKKIAKQKSVIDVYTEKLISEGTFSKKDIDEHKKWVWNLFEDAFEKAKDYVPSQREWLTAAWEGFKSPKELATEILPHEPTNVPESTLKELGKVLSSWPEGFEVHKNLKRILKNRGKSIETGEGIDWATGEALAFGTLVLDGQNVRVSGEDVERGTFSQRHAVLHDQQSEAIYTPLSTLNNEKADFTIANSSLSEYGVMGFEYGYSLTSPDYLVMWEAQFGDFANTAQVIIDQFIAGGEQKWKQRSGLVLSLPHGYDGQGPEHSSGRLERFLQLANEDPRYFPSEEKLQRQHQDCNFQVVYPTTPANLFHILRRQQHRQFRKPLALFFSKQLLRHPLARSSLSEFTEGGFQWIIEDIEHGKSIGTKEETKRLVLLSGQVYTALHKRRESLGDKTTAFLKIEQLHPFPFAQLRDSLNSYPNLEEIVWCQEEPLNMGSWAYTEPRLHTTLKETDKYKDFKVRYCGRNPSGAVAAGSKSLHLAEEDAFLKDVFQQS

Entrez Gene ID

Gene Name

alpha-ketoglutarate dehydrogenase KGD1

Gene Symbol

KGD1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0042645	IDA:SGD	C	mitochondrial nucleoid
GO:0009353	IDA:SGD	C	mitochondrial oxoglutarate dehydrogenase complex
GO:0004591	TAS:SGD	F	oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0030976	IEA:InterPro	F	thiamine pyrophosphate binding
GO:0006103	TAS:SGD	P	2-oxoglutarate metabolic process
GO:0006099	TAS:SGD	P	tricarboxylic acid cycle

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
ko01200	Carbon metabolism
sce01200	Carbon metabolism
ko00020	Citrate cycle (TCA cycle)
sce00020	Citrate cycle (TCA cycle)
M00009	Citrate cycle (TCA cycle, Krebs cycle)
sce_M00009	Citrate cycle (TCA cycle, Krebs cycle)
M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
sce_M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
ko00310	Lysine degradation
sce00310	Lysine degradation
sce01100	Metabolic pathways
ko00380	Tryptophan metabolism
sce00380	Tryptophan metabolism

BIOCYC Pathway ID	Description
PWY-5084	2-ketoglutarate dehydrogenase complex
TCA-EUK-PWY-YEAST	TCA cycle, aerobic respiration

REACTOME Pathway ID	Description
5618051	Citric acid cycle (TCA cycle)
5618050	Lysine catabolism
5618023	Metabolism
5618041	Metabolism of amino acids and derivatives
5618052	Pyruvate metabolism and Citric Acid (TCA) cycle
5618053	The citric acid (TCA) cycle and respiratory electron transport

Accession	Description
IPR011603	2-oxoglutarate dehydrogenase E1 component
IPR001017	Dehydrogenase, E1 component
IPR029061	Thiamin diphosphate-binding fold
IPR005475	Transketolase-like, pyrimidine-binding domain

Gene Name

alpha-ketoglutarate dehydrogenase KGD1

Protein Entry

ODO1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
Cofactor	Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
Enzyme Regulation	Catabolite repressed.
Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). {ECO:0000269\|PubMed:11926067, ECO:0000269\|PubMed:2503710, ECO:0000269\|PubMed:8299151}.
Miscellaneous	Present with 14300 molecules/cell in log phase SD medium
Miscellaneous	Present with 14300 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the alpha-ketoglutarate dehydrogenase family
Similarity	Belongs to the alpha-ketoglutarate dehydrogenase family. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.