Gene/Proteome Database (LMPD)

LMPD ID
LMP007358
Gene ID
855197
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
aminophospholipid-translocating P4-type ATPase DNF3
Gene Symbol
DNF3
Synonyms
-
Alternate Names
aminophospholipid-translocating P4-type ATPase DNF3
Chromosome
XIII
EC Number
3.6.3.1

Proteins

aminophospholipid-translocating P4-type ATPase DNF3
Refseq ID NP_013885
Protein GI 6323814
UniProt ID Q12674
mRNA ID NM_001182666
Length 1656
RefSeq Status PROVISIONAL
MGIADGQRRRSSSLRTQMFNKHLYDKYRGRTDDEIELEDINESKTFSGSDNNDKDDRDETSGNYAAEEDYEMEEYGSPDVSYSIITKILDTILDRRRTFHSKDGRHIPIILDHNAIEYKQAATKRDGHLIDERFNKPYCDNRITSSRYTFYSFLPRQLYAQFSKLANTYFFIVAVLQMIPGWSTTGTYTTIIPLCVFMGISMTREAWDDFRRHRLDKEENNKPVGVLVKDGNNDAQEVYTLPSSVVSSTAYLTKSAAAENNPPLNDDRNSSQGHFLDTHFNNFELLKNKYNVHIHQKKWEKLRVGDFVLLTQDDWVPADLLLLTCDGENSECFVETMALDGETNLKSKQPHPELNKLTKAASGLANINAQVTVEDPNIDLYNFEGNLELKNHRNDTIMKYPLGPDNVIYRGSILRNTQNVVGMVIFSGEETKIRMNALKNPRTKAPKLQRKINMIIVFMVFVVATISLFSYLGHVLHKKKYIDQNKAWYLFQADAGVAPTIMSFIIMYNTVIPLSLYVTMEIIKVVQSKMMEWDIDMYHAETNTPCESRTATILEELGQVSYIFSDKTGTLTDNKMIFRKFSLCGSSWLHNVDLGNSEDNFEDNRDNTNSLRLPPKAHNGSSIDVVSIGDQNVLDRLGFSDAPIEKGHRPSLDNFPKSRNSIEYKGNSSAIYTGRPSMRSLFGKDNSHLSKQASVISPSETFSENIKSSFDLIQFIQRYPTALFSQKAKFFFLSLALCHSCLPKKTHNESIGEDSIEYQSSSPDELALVTAARDLGYIVLNRNAQILTIKTFPDGFDGEAKLENYEILNYIDFNSQRKRMSVLVRMPNQPNQVLLICKGADNVIMERLHDRELAAKKMADICTSTKERKDAEAELVLQQRKSLERMVDEEAMARTSLRNSLSSVPRASLSLQAVRKSLSMKNSRTRDPEKQIDSIDQFLETVKKSDQEIGSVVNKSRKSLHKQQIEKYGPRISIDGTHFPNNNVPIDTRKEGLQHDYDTEILEHIGSDELILNEEYVIERTLQAIDEFSTEGLRTLVYAYKWIDIGQYENWNKRYHQAKTSLTDRKIKVDEAGAEIEDGLNLLGVTAIEDKLQDGVSEAIEKIRRAGIKMWMLTGDKRETAINIGYSCMLIKDYSTVVILTTTDENIISKMNAVSQEVDSGNIAHCVVVIDGATMAMFEGNPTYMSVFVELCTKTDSVICCRASPSQKALMVSNIRNTDPNLVTLAIGDGANDIAMIQSADIGVGIAGKEGLQASRVSDYSIGQFRFLLKLLFVHGRYNYIRTSKFMLCTFYKEITFYFTQLIYQRYTMFSGSSLYEPWSLSMFNTLFTSLPVLCIGMFEKDLKPMTLLTVPELYSYGRLSQGFNWLIFMEWVILATTNSLIITFLNVVMWGMSSLSDNTMYPLGLINFTAIVALINVKSQFVEMHNRNWLAFTSVVLSCGGWLVWCCALPILNNTDQIYDVAYGFYNHFGKDITFWCTSLVLALLPITLDIVYKTFKVMIWPSDSDIFAELEQKSDIRKKLELGAYSEMRQGWTWDKDPSTFTRYTDKVLSRPRTNSRASAKTHNSSIYSMSNGNVDHSSKKNFFGNSSKKSSERYEVLPSGKLIKRPSLKTQSSKDSIGGNITTKLTKKLKLPSRNVEDEDVNQIIQARLKDLE

Gene Information

Entrez Gene ID
855197
Gene Name
aminophospholipid-translocating P4-type ATPase DNF3
Gene Symbol
DNF3
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005802 IDA:SGD C trans-Golgi network
GO:0030140 IDA:SGD C trans-Golgi network transport vesicle
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0019829 IEA:InterPro F cation-transporting ATPase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0004012 IMP:SGD F phospholipid-translocating ATPase activity
GO:0006886 IGI:SGD P intracellular protein transport
GO:0045332 IMP:SGD P phospholipid translocation

REACTOME Pathway Links

REACTOME Pathway ID Description
5618495 Ion channel transport
5618494 Ion transport by P-type ATPases
5618037 Transmembrane transport of small molecules

Domain Information

InterPro Annotations

Accession Description
IPR008250 ATPase_P-typ_transduc_dom_A
IPR001757 Cation_transp_P_typ_ATPase
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N
IPR018303 P-type ATPase, phosphorylation site
IPR006539 P-type ATPase, subfamily IV

UniProt Annotations

Entry Information

Gene Name
aminophospholipid-translocating P4-type ATPase DNF3
Protein Entry
ATC8_YEAST
UniProt ID
Q12674
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. {ECO:0000305}.
Similarity Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}.
Subcellular Location Membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007358 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323814 RefSeq NP_013885 1656 aminophospholipid-translocating P4-type ATPase DNF3

Identical Sequences to LMP007358 proteins

Reference Database Accession Length Protein Name
GI:6323814 EMBL CAA89798.1 1656 unknown [Saccharomyces cerevisiae]
GI:6323814 GenBank ABZ27956.1 1656 Sequence 1894 from patent US 7314974
GI:6323814 SwissProt Q12674.1 1656 RecName: Full=Probable phospholipid-transporting ATPase DNF3 [Saccharomyces cerevisiae S288c]
GI:6323814 Third Party Genbank DAA10058.1 1656 TPA: aminophospholipid-translocating P4-type ATPase DNF3 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007358 proteins

Reference Database Accession Length Protein Name
GI:6323814 GenBank EGT53931.1 894 hypothetical protein CAEBREN_25754 [Caenorhabditis brenneri]
GI:6323814 GenBank EHN05405.1 1656 Dnf3p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6323814 GenBank EIW08425.1 1656 Dnf3p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323814 GenBank EWG84082.1 1656 Dnf3p [Saccharomyces cerevisiae R008]
GI:6323814 GenBank EWG94106.1 1656 Dnf3p [Saccharomyces cerevisiae R103]
GI:6323814 GenBank EWH16763.1 1656 Dnf3p [Saccharomyces cerevisiae P283]