Gene/Proteome Database (LMPD)

LMPD ID
LMP007353
Gene ID
855260
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
phosphomevalonate kinase
Gene Symbol
ERG8
Synonyms
-
Chromosome
XIII
EC Number
2.7.4.2;

Proteins

phosphomevalonate kinase
Refseq ID NP_013947
Protein GI 6323876
UniProt ID P24521
mRNA ID NM_001182727
Length 451
MSELRAFSAPGKALLAGGYLVLDTKYEAFVVGLSARMHAVAHPYGSLQGSDKFEVRVKSKQFKDGEWLYHISPKSGFIPVSIGGSKNPFIEKVIANVFSYFKPNMDDYCNRNLFVIDIFSDDAYHSQEDSVTEHRGNRRLSFHSHRIEEVPKTGLGSSAGLVTVLTTALASFFVSDLENNVDKYREVIHNLAQVAHCQAQGKIGSGFDVAAAAYGSIRYRRFPPALISNLPDIGSATYGSKLAHLVDEEDWNITIKSNHLPSGLTLWMGDIKNGSETVKLVQKVKNWYDSHMPESLKIYTELDHANSRFMDGLSKLDRLHETHDDYSDQIFESLERNDCTCQKYPEITEVRDAVATIRRSFRKITKESGADIEPPVQTSLLDDCQTLKGVLTCLIPGAGGYDAIAVITKQDVDLRAQTANDKRFSKVQWLDVTQADWGVRKEKDPETYLDK

Gene Information

Entrez Gene ID
855260
Gene Name
phosphomevalonate kinase
Gene Symbol
ERG8
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004631 IMP:SGD F phosphomevalonate kinase activity
GO:0006696 IMP:SGD P ergosterol biosynthetic process
GO:0010142 IMP:SGD P farnesyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287 IMP:SGD P isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0031388 IMP:SGD P organic acid phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
sce01110 Biosynthesis of secondary metabolites
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
sce_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
sce01100 Metabolic pathways
ko00900 Terpenoid backbone biosynthesis
sce00900 Terpenoid backbone biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7391 isoprene biosynthesis II (engineered)
PWY-922 mevalonate pathway
PWY-922 mevalonate pathway I
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis I
PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)

Domain Information

InterPro Annotations

Accession Description
IPR006204 GHMP kinase N-terminal domain
IPR006203 GHMP kinase, ATP-binding, conserved site
IPR013750 GHMP kinase, C-terminal domain
IPR016005 Pmev_kin_ERG8
IPR005916 Pmev_kin_euk
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup

UniProt Annotations

Entry Information

Gene Name
phosphomevalonate kinase
Protein Entry
ERG8_YEAST
UniProt ID
P24521
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + (R)-5-phosphomevalonate = ADP + (R)-5- diphosphomevalonate.
Miscellaneous Present with 79 molecules/cell in log phase SD medium
Miscellaneous Present with 79 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.
Similarity Belongs to the GHMP kinase family. Mevalonate kinase subfamily
Similarity Belongs to the GHMP kinase family. Mevalonate kinase subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP007353 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323876 RefSeq NP_013947 451 phosphomevalonate kinase

Identical Sequences to LMP007353 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007353 proteins

Reference Database Accession Length Protein Name