LIPID MAPS

LMPD ID

LMP007325

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Pkp2p

Gene Symbol

PKP2

Synonyms

-

Chromosome

VII

EC Number

2.7.11.2

Pkp2p
Refseq ID	NP_011456
Protein GI	398364691
UniProt ID	P53170
mRNA ID	NM_001180924
Length	491
MSKYQINCIRYRHFLRTSNISQIPDFTKYCIGPVNEELAPYIMETMKAYPSNSEYINPQHYYHNRTVLVENYLKRSPNPVSLTQLAQYYDDSTKLTRTKIINSGKFVKEELVIRIAHKLNQLQQLPFNVVNNFHFVQVYESYYNIFESFRKYPTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPREKMDQLLSDLLRARISRRLIVEEHVSITANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQKFIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPEPIIVTVVSNDESYLFRISDKAGGVLHDDENLWSFGKSKERAQESLNNFHKLPGLQTVSIYDEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGLAMCKVYAEYWNGDLSLHSMPGYGTDVVLKLGNLMKHTKKLQLDKV

Entrez Gene ID

Gene Name

Pkp2p

Gene Symbol

PKP2

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005739	IDA:SGD	C	mitochondrion
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0004672	IDA:SGD	F	protein kinase activity
GO:0004674	IEA:UniProtKB-KW	F	protein serine/threonine kinase activity
GO:0004740	IMP:SGD	F	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0015976	IGI:SGD	P	carbon utilization
GO:0006006	IEA:UniProtKB-KW	P	glucose metabolic process
GO:0043086	IMP:SGD	P	negative regulation of catalytic activity
GO:0018105	IMP:SGD	P	peptidyl-serine phosphorylation

REACTOME Pathway ID	Description
5618023	Metabolism
5618056	Pyruvate metabolism
5618052	Pyruvate metabolism and Citric Acid (TCA) cycle
5618430	Regulation of pyruvate dehydrogenase (PDH) complex
5618053	The citric acid (TCA) cycle and respiratory electron transport

Accession	Description
IPR018955	Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
IPR003594	Histidine kinase-like ATPase, C-terminal domain

Gene Name

Pkp2p

Protein Entry

PDK2_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	ATP + [pyruvate dehydrogenase (acetyl- transferring)] = ADP + [pyruvate dehydrogenase (acetyl- transferring)] phosphate.
Function	Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism. {ECO:0000269\|PubMed:16319894, ECO:0000269\|PubMed:17918780, ECO:0000269\|PubMed:18180296}.
Interaction	P40530:PKP1; NbExp=3; IntAct=EBI-23792, EBI-2610722;
Miscellaneous	Present with 450 molecules/cell in log phase SD medium
Miscellaneous	Present with 450 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Sequence Caution	Sequence=CAA96762.1; Type=Frameshift; Positions=435; Evidence= ;
Sequence Caution	Sequence=CAA96762.1; Type=Frameshift; Positions=435; Evidence={ECO:0000305};
Similarity	Belongs to the PDK/BCKDK protein kinase family
Similarity	Belongs to the PDK/BCKDK protein kinase family. {ECO:0000305}.
Similarity	Contains 1 histidine kinase domain
Similarity	Contains 1 histidine kinase domain. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:16823961, ECO:0000269\|PubMed:17918780, ECO:0000269\|PubMed:18180296}.
Subunit	Interacts with PKP1
Subunit	Interacts with PKP1. {ECO:0000269\|PubMed:18180296}.