Gene/Proteome Database (LMPD)

LMPD ID
LMP007313
Gene ID
850947
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Erf2p
Gene Symbol
ERF2
Synonyms
-
Alternate Names
Erf2p
Chromosome
XII
EC Number
2.3.1.225

Proteins

Erf2p
Refseq ID NP_013347
Protein GI 6323275
UniProt ID Q06551
mRNA ID NM_001182133
Length 359
RefSeq Status PROVISIONAL
MALVSRRSTRSESTSITKEEHTGEGSLTKLFFRWLVTLEGDQDINDGKGYISLPNVSNYIFFLGGRFRTVKGAKPLWLGVLLAIVCPMVLFSIFEAHKLWHTQNGYKVLVIFFYYFWVITLASFIRTATSDPGVLPRNIHLSQLRNNYQIPQEYYNLITLPTHSSISKDITIKYCPSCRIWRPPRSSHCSTCNVCVMVHDHHCIWVNNCIGKRNYRFFLIFLLGAILSSVILLTNCAIHIARESGGPRDCPVAILLLCYAGLTLWYPAILFTYHIFMAGNQQTTREFLKGIGSKKNPVFHRVVKEENIYNKGSFLKNMGHLMLEPRGPSFVSARKPHEAGDWRFMDLSPAHSFEKIQKI

Gene Information

Entrez Gene ID
850947
Gene Name
Erf2p
Gene Symbol
ERF2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0032541 IDA:UniProt C cortical endoplasmic reticulum
GO:0031211 IPI:SGD C endoplasmic reticulum palmitoyltransferase complex
GO:0030176 IDA:SGD C integral component of endoplasmic reticulum membrane
GO:0097038 IDA:UniProt C perinuclear endoplasmic reticulum
GO:0016409 IDA:SGD F palmitoyltransferase activity
GO:0019706 IEA:UniProtKB-EC F protein-cysteine S-palmitoyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0018345 IDA:SGD P protein palmitoylation
GO:0006612 IMP:SGD P protein targeting to membrane

Domain Information

InterPro Annotations

Accession Description
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase

UniProt Annotations

Entry Information

Gene Name
Erf2p
Protein Entry
ERFB_YEAST
UniProt ID
Q06551
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain The DHHC domain is required for palmitoyltransferase activity.
Function The ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization. {ECO:0000269|PubMed:12193598}.
Ptm Autopalmitoylated.
Similarity Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. {ECO:0000305}.
Similarity Contains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10490616, ECO:0000269|PubMed:12379641}; Multi- pass membrane protein {ECO:0000269|PubMed:10490616, ECO:0000269|PubMed:12379641}.
Subunit Interacts with SHR5. {ECO:0000269|PubMed:12193598, ECO:0000269|PubMed:12379641}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007313 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323275 RefSeq NP_013347 359 Erf2p

Identical Sequences to LMP007313 proteins

Reference Database Accession Length Protein Name
GI:6323275 GenBank ACN08148.1 359 Sequence 2 from patent US 7488592
GI:6323275 GenBank ACN08151.1 359 Sequence 6 from patent US 7488592
GI:6323275 GenBank AED39500.1 359 Sequence 2 from patent US 7883860
GI:6323275 GenBank AED39503.1 359 Sequence 6 from patent US 7883860
GI:6323275 GenBank EIW08851.1 359 Erf2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323275 Third Party Genbank DAA09560.1 359 TPA: Erf2p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007313 proteins

Reference Database Accession Length Protein Name
GI:6323275 DBBJ GAA25115.1 359 K7_Erf2p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6323275 GenBank AAT92932.1 359 YLR246W [Saccharomyces cerevisiae]
GI:6323275 GenBank EDN59462.1 359 Ras palmitoyltransferase [Saccharomyces cerevisiae YJM789]
GI:6323275 GenBank EGA57581.1 359 Erf2p [Saccharomyces cerevisiae FostersB]
GI:6323275 GenBank EGA77765.1 359 Erf2p [Saccharomyces cerevisiae Vin13]
GI:6323275 GenBank EGA85665.1 359 Erf2p [Saccharomyces cerevisiae VL3]