Gene/Proteome Database (LMPD)

LMPD ID
LMP007288
Gene ID
851904
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Gic2p
Gene Symbol
GIC2
Synonyms
-
Alternate Names
Gic2p
Chromosome
IV

Proteins

Gic2p
Refseq ID NP_010595
Protein GI 6320515
UniProt ID Q06648
mRNA ID NM_001180617
Length 383
RefSeq Status PROVISIONAL
MTSASITNTGNETMNLPQMRSIWLDEDEEAEKLYGLQAQQFMGSDDEENLGITFINSDKPVLSNKKNIELPPLSPNSHPSCHHRRSNSNSAKSKESSSSSSSANKTNHKKVFLKLNLLKKKLLGAQPDIRGKGISTPFDFQHISHADTRNGFQDEQLQEPSSLSTEIKDDYTSSSSKRDSKSLNKAFVTERIPANRESKLISRSHENKTSRLSVARSISVTSSNYSKNTQGNNHSINGRVVSTSTMATSIFEYSPNASPKQFKNKSHALGHRYTNSTDSSESSLDFLKNYNFPTLLEDKPILDFLPRSQRSSAYRSLLETPNSNKDSAKAFFPSRQSPLPKRRNSIATPSPQSKFSYSDSPVNHRKSFDDVLYSFNQLEPLQT

Gene Information

Entrez Gene ID
851904
Gene Name
Gic2p
Gene Symbol
GIC2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005934 IDA:SGD C cellular bud tip
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005856 IEA:UniProtKB-KW C cytoskeleton
GO:0000131 IDA:SGD C incipient cellular bud site
GO:0043332 IDA:SGD C mating projection tip
GO:0005886 IGI:SGD C plasma membrane
GO:0005100 IDA:SGD F Rho GTPase activator activity
GO:0017048 IPI:SGD F Rho GTPase binding
GO:0005546 IDA:SGD F phosphatidylinositol-4,5-bisphosphate binding
GO:0030010 IGI:SGD P establishment of cell polarity
GO:0032321 IDA:GOC P positive regulation of Rho GTPase activity
GO:0090338 IMP:SGD P positive regulation of formin-nucleated actin cable assembly
GO:0008360 IEA:UniProtKB-KW P regulation of cell shape
GO:0007096 IMP:SGD P regulation of exit from mitosis

Domain Information

InterPro Annotations

Accession Description
IPR000095 CRIB domain

UniProt Annotations

Entry Information

Gene Name
Gic2p
Protein Entry
GIC2_YEAST
UniProt ID
Q06648
Species
Yeast (S288c)

Comments

Comment Type Description
Function Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.
Interaction P32458:CDC11; NbExp=2; IntAct=EBI-7585, EBI-4178; P32468:CDC12; NbExp=5; IntAct=EBI-7585, EBI-4182; P32457:CDC3; NbExp=3; IntAct=EBI-7585, EBI-4429;
Miscellaneous Present with 1130 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the BORG/CEP family. {ECO:0000305}.
Similarity Contains 1 CRIB domain. {ECO:0000255|PROSITE- ProRule:PRU00057}.
Subcellular Location Bud neck {ECO:0000250}. Bud tip {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Subunit Interacts with GTP-bound CDC42.

Identical and Related Proteins

Unique RefSeq proteins for LMP007288 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320515 RefSeq NP_010595 383 Gic2p

Identical Sequences to LMP007288 proteins

Reference Database Accession Length Protein Name
GI:6320515 DBBJ GAA22529.1 383 K7_Gic2p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6320515 GenBank EIW11516.1 383 Gic2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320515 GenBank EWG87323.1 383 Gic2p [Saccharomyces cerevisiae R008]
GI:6320515 GenBank EWG91979.1 383 Gic2p [Saccharomyces cerevisiae P301]
GI:6320515 GenBank EWG96607.1 383 Gic2p [Saccharomyces cerevisiae R103]
GI:6320515 GenBank EWH19014.1 383 Gic2p [Saccharomyces cerevisiae P283]

Related Sequences to LMP007288 proteins

Reference Database Accession Length Protein Name
GI:6320515 GenBank EDN60637.1 383 GTPase-interacting component [Saccharomyces cerevisiae YJM789]
GI:6320515 GenBank EEU06821.1 383 Gic2p [Saccharomyces cerevisiae JAY291]
GI:6320515 GenBank EGA59159.1 383 Gic2p [Saccharomyces cerevisiae FostersB]
GI:6320515 GenBank EGA79462.1 370 Gic2p [Saccharomyces cerevisiae Vin13]
GI:6320515 GenBank EGA83414.1 370 Gic2p [Saccharomyces cerevisiae Lalvin QA23]
GI:6320515 gnl McCuskerlabDuke 383 Gic2p [Saccharomyces cerevisiae YJM993]