Gene/Proteome Database (LMPD)
Proteins
| aminophospholipid-translocating P4-type ATPase DNF2 | |
|---|---|
| Refseq ID | NP_010378 |
| Protein GI | 6320298 |
| UniProt ID | Q12675 |
| mRNA ID | NM_001180401 |
| Length | 1612 |
| RefSeq Status | PROVISIONAL |
| MSSPSKPTSPFVDDIEHESGSASNGLSSMSPFDDSFQFEKPSSAHGNIEVAKTGGSVLKRQSKPMKDISTPDLSKVTFDGIDDYSNDNDINDDDELNGKKTEIHEHENEVDDDLHSFQATPMPNTGGFEDVELDNNEGSNNDSQADHKLKRVRFGTRRNKSGRIDINRSKTLKWAKKNFHNAIDEFSTKEDSLENSALQNRSDELRTVYYNLPLPEDMLDEDGLPLAVYPRNKIRTTKYTPLTFFPKNILFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITAIKDGIEDSRRTVLDLEVNNTRTHILSGVKNENVAVDNVSLWRRFKKANTRALIKIFEYFSENLTAAGREKKLQKKREELRRKRNSRSFGPRGSLDSIGSYRMSADFGRPSLDYENLNQTMSQANRYNDGENLVDRTLQPNPECRFAKDYWKNVKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETNLKVRQSLKCSKIIKSSRDITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPVNINNLLLRGCTLRNTKWAMGMVIFTGDDTKIMINAGVTPTKKSRISRELNFSVILNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGVDVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGDHQQKCCEHFLLALALCHSVLVEPNKDDPKKLDIKAQSPDESALVSTARQLGYSFVGSSKSGLIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIPGSTPKDEPKALLICKGADSVIYSRLDRTQNDATLLEKTALHLEEYATEGLRTLCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAIEDRLQDGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELLVVKASGEDVEEFGSDPIQVVNNLVTKYLREKFGMSGSEEELKEAKREHGLPQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCKAVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAIGQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNFDGSYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRKEWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTSCNFYVFMEQYRWDWFCGLFICLSLAVFYGWTGIWTSSSSSNEFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRKIFYPKDIEIVREMWLRGDFDLYPQGYDPTDPSRPRINEIRPLTDFKEPISLDTHFDGVSHSQETIVTEEIPMSILNGEQGSRKGYRVSTTLERRDQLSPVTTTNNLPRRSMASARGNKLRTSLDRTREEMLANHQLDTRYSVERARASLDLPGINHAETLLSQRSRDR | |
Gene Information
Entrez Gene ID
Gene Name
aminophospholipid-translocating P4-type ATPase DNF2
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IDA:SGD | C | plasma membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0019829 | IEA:InterPro | F | cation-transporting ATPase activity |
| GO:0000287 | IEA:InterPro | F | magnesium ion binding |
| GO:0004012 | IMP:SGD | F | phospholipid-translocating ATPase activity |
| GO:0006897 | IMP:SGD | P | endocytosis |
| GO:0007163 | IGI:SGD | P | establishment or maintenance of cell polarity |
| GO:0006886 | IGI:SGD | P | intracellular protein transport |
| GO:0045332 | IMP:SGD | P | phospholipid translocation |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR008250 | ATPase_P-typ_transduc_dom_A |
| IPR001757 | Cation_transp_P_typ_ATPase |
| IPR023214 | HAD-like domain |
| IPR023299 | P-type ATPase, cytoplasmic domain N |
| IPR018303 | P-type ATPase, phosphorylation site |
| IPR006539 | P-type ATPase, subfamily IV |
| IPR026871 | Phospholipid-transporting P-type ATPase |
UniProt Annotations
Entry Information
Gene Name
aminophospholipid-translocating P4-type ATPase DNF2
Protein Entry
ATC4_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). |
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles. {ECO:0000269|PubMed:12221123}. |
| Ptm | Phosphorylated by FPK1 and KIN82. {ECO:0000269|PubMed:15665377, ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18199685, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198}. |
| Similarity | Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12221123, ECO:0000269|PubMed:18199685}; Multi-pass membrane protein {ECO:0000269|PubMed:12221123, ECO:0000269|PubMed:18199685}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007265 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6320298 | RefSeq | NP_010378 | 1612 | aminophospholipid-translocating P4-type ATPase DNF2 |
Identical Sequences to LMP007265 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6320298 | EMBL | CAA87668.1 | 1612 | probable ATPase [Saccharomyces cerevisiae] |
| GI:6320298 | EMBL | CAY78600.1 | 1612 | Dnf2p [Saccharomyces cerevisiae EC1118] |
| GI:6320298 | GenBank | ABZ27690.1 | 1612 | Sequence 1628 from patent US 7314974 |
| GI:6320298 | GenBank | EWG97063.1 | 1612 | Dnf2p [Saccharomyces cerevisiae R103] |
| GI:6320298 | SwissProt | Q12675.1 | 1612 | RecName: Full=Phospholipid-transporting ATPase DNF2; AltName: Full=Flippase DNF2 [Saccharomyces cerevisiae S288c] |
| GI:6320298 | Third Party Genbank | DAA11940.1 | 1612 | TPA: aminophospholipid-translocating P4-type ATPase DNF2 [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP007265 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6320298 | GenBank | EDN60439.1 | 1450 | drs2 neo1 family protein [Saccharomyces cerevisiae YJM789] |
| GI:6320298 | GenBank | EEU05126.1 | 1612 | Dnf2p [Saccharomyces cerevisiae JAY291] |
| GI:6320298 | GenBank | EIW11299.1 | 1548 | Dnf2p [Saccharomyces cerevisiae CEN.PK113-7D] |
| GI:6320298 | GenBank | EWG87145.1 | 1612 | Dnf2p [Saccharomyces cerevisiae R008] |
| GI:6320298 | GenBank | EWG91835.1 | 1612 | Dnf2p [Saccharomyces cerevisiae P301] |
| GI:6320298 | gnl | McCuskerlabDuke | 1612 | Dnf2p [Saccharomyces cerevisiae YJM993] |