Gene/Proteome Database (LMPD)

LMPD ID
LMP007258
Gene ID
855750
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
acetyl-CoA carboxylase ACC1
Gene Symbol
ACC1
Synonyms
ABP2; FAS3; MTR7
Alternate Names
acetyl-CoA carboxylase ACC1
Chromosome
XIV
EC Number
6.4.1.2

Proteins

acetyl-CoA carboxylase ACC1
Refseq ID NP_014413
Protein GI 6324343
UniProt ID Q00955
mRNA ID NM_001183193
Length 2233
RefSeq Status PROVISIONAL
MSEESLFESSPQKMEYEITNYSERHTELPGHFIGLNTVDKLEESPLRDFVKSHGGHTVISKILIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPEDLEANAEYIRMADQYIEVPGGTNNNNYANVDLIVDIAERADVDAVWAGWGHASENPLLPEKLSQSKRKVIFIGPPGNAMRSLGDKISSTIVAQSAKVPCIPWSGTGVDTVHVDEKTGLVSVDDDIYQKGCCTSPEDGLQKAKRIGFPVMIKASEGGGGKGIRQVEREEDFIALYHQAANEIPGSPIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIAKAETFHEMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIPKGHCTACRITSEDPNDGFKPSGGTLHELNFRSSSNVWGYFSVGNNGNIHSFSDSQFGHIFAFGENRQASRKHMVVALKELSIRGDFRTTVEYLIKLLETEDFEDNTITTGWLDDLITHKMTAEKPDPTLAVICGAATKAFLASEEARHKYIESLQKGQVLSKDLLQTMFPVDFIHEGKRYKFTVAKSGNDRYTLFINGSKCDIILRQLSDGGLLIAIGGKSHTIYWKEEVAATRLSVDSMTTLLEVENDPTQLRTPSPGKLVKFLVENGEHIIKGQPYAEIEVMKMQMPLVSQENGIVQLLKQPGSTIVAGDIMAIMTLDDPSKVKHALPFEGMLPDFGSPVIEGTKPAYKFKSLVSTLENILKGYDNQVIMNASLQQLIEVLRNPKLPYSEWKLHISALHSRLPAKLDEQMEELVARSLRRGAVFPARQLSKLIDMAVKNPEYNPDKLLGAVVEPLADIAHKYSNGLEAHEHSIFVHFLEEYYEVEKLFNGPNVREENIILKLRDENPKDLDKVALTVLSHSKVSAKNNLILAILKHYQPLCKLSSKVSAIFSTPLQHIVELESKATAKVALQAREILIQGALPSVKERTEQIEHILKSSVVKVAYGSSNPKRSEPDLNILKDLIDSNYVVFDVLLQFLTHQDPVVTAAAAQVYIRRAYRAYTIGDIRVHEGVTVPIVEWKFQLPSAAFSTFPTVKSKMGMNRAVSVSDLSYVANSQSSPLREGILMAVDHLDDVDEILSQSLEVIPRHQSSSNGPAPDRSGSSASLSNVANVCVASTEGFESEEEILVRLREILDLNKQELINASIRRITFMFGFKDGSYPKYYTFNGPNYNENETIRHIEPALAFQLELGRLSNFNIKPIFTDNRNIHVYEAVSKTSPLDKRFFTRGIIRTGHIRDDISIQEYLTSEANRLMSDILDNLEVTDTSNSDLNHIFINFIAVFDISPEDVEAAFGGFLERFGKRLLRLRVSSAEIRIIIKDPQTGAPVPLRALINNVSGYVIKTEMYTEVKNAKGEWVFKSLGKPGSMHLRPIATPYPVKEWLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNELIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITFKIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVRLGQRAIQVEGQPIILTGAPAINKMLGREVYTSNLQLGGTQIMYNNGVSHLTAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETYDVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGVIGVETRTVENLIPADPANPNSAETLIQEPGQVWHPNSAFKTAQAINDFNNGEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPTGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPQGMVGIKFRREKLLDTMNRLDDKYRELRSQLSNKSLAPEVHQQISKQLADRERELLPIYGQISLQFADLHDRSSRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSHQVGEASRLEKIARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGLKLESFAQDLAKKIRSDHDNAIDGLSEVIKMLSTDDKEKLLKTLK

Gene Information

Entrez Gene ID
855750
Gene Name
acetyl-CoA carboxylase ACC1
Gene Symbol
ACC1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:SGD C endoplasmic reticulum membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003989 IMP:SGD F acetyl-CoA carboxylase activity
GO:0004075 IMP:SGD F biotin carboxylase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0042759 IMP:SGD P long-chain fatty acid biosynthetic process
GO:2001295 IEA:UniProtKB-UniPathway P malonyl-CoA biosynthetic process
GO:0006998 TAS:SGD P nuclear envelope organization
GO:0006606 IMP:SGD P protein import into nucleus

KEGG Pathway Links

KEGG Pathway ID Description
sce00061 Fatty acid biosynthesis
sce_M00082 Fatty acid biosynthesis, initiation
sce00620 Pyruvate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR011761 ATP-grasp fold
IPR013815 ATP-grasp fold, subdomain 1
IPR013816 ATP-grasp fold, subdomain 2
IPR013537 Acetyl-CoA carboxylase, central domain
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR011764 Biotin carboxylation domain
IPR001882 Biotin-binding site
IPR000089 Biotin/lipoyl attachment
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR000022 Carboxyl transferase
IPR029045 ClpP/crotonase-like domain
IPR016185 Pre-ATP-grasp domain
IPR011054 Rudiment single hybrid motif
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA carboxylase ACC1
Protein Entry
ACAC_YEAST
UniProt ID
Q00955
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
Catalytic Activity ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein].
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
Cofactor Name=biotin; Xref=ChEBI:CHEBI:57586; Evidence={ECO:0000250}; Note=Biotin. {ECO:0000250};
Enzyme Regulation By phosphorylation. The catalytic activity is inhibited by soraphen A, a polyketide isolated from the myxobacterium Sorangium cellulosum and a potent inhibitor of fungal growth. {ECO:0000269|PubMed:7916271}.
Function Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole. {ECO:0000269|PubMed:10757783, ECO:0000269|PubMed:12730220, ECO:0000269|PubMed:6103540, ECO:0000269|PubMed:6108218, ECO:0000269|PubMed:8943372}.
Induction Repressed in presence of fatty acids. Repressed 3-fold by lipid precursors, inositol and choline, and also controlled by regulatory factors INO2, INO4 and OPI1. {ECO:0000269|PubMed:1359536, ECO:0000269|PubMed:8098706, ECO:0000269|PubMed:8127678}.
Miscellaneous Present with 20200 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
Similarity Contains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
Similarity Contains 1 biotin carboxylation domain. {ECO:0000305}.
Similarity Contains 1 biotinyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Similarity Contains 1 carboxyltransferase domain. {ECO:0000305}.
Subcellular Location Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Subunit Homodimer. {ECO:0000269|PubMed:12663926, ECO:0000269|PubMed:15079078, ECO:0000269|PubMed:15610732}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007258 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324343 RefSeq NP_014413 2233 acetyl-CoA carboxylase ACC1

Identical Sequences to LMP007258 proteins

Reference Database Accession Length Protein Name
GI:6324343 GenBank AGX52172.1 2233 Sequence 4699 from patent US 8541208
GI:6324343 GenBank AGX52804.1 2233 Sequence 5959 from patent US 8541208
GI:6324343 GenBank AGX53740.1 2233 Sequence 7830 from patent US 8541208
GI:6324343 GenBank AGX56007.1 2233 Sequence 12340 from patent US 8541208
GI:6324343 GenBank AGX60422.1 2233 Sequence 21075 from patent US 8541208
GI:6324343 GenBank AGX77055.1 2233 Sequence 53884 from patent US 8541208

Related Sequences to LMP007258 proteins

Reference Database Accession Length Protein Name
GI:6324343 GenBank EDN62822.1 2233 acetyl CoA carboxylase [Saccharomyces cerevisiae YJM789]
GI:6324343 GenBank EDV12250.1 2233 acetyl CoA carboxylase [Saccharomyces cerevisiae RM11-1a]
GI:6324343 GenBank EEU08272.1 2233 Acc1p [Saccharomyces cerevisiae JAY291]
GI:6324343 GenBank EWG88892.1 2233 Acc1p [Saccharomyces cerevisiae P301]
GI:6324343 GenBank EWH16255.1 2233 Acc1p [Saccharomyces cerevisiae P283]
GI:6324343 gnl McCuskerlabDuke 2233 Acc1p [Saccharomyces cerevisiae YJM993]