Gene/Proteome Database (LMPD)

LMPD ID
LMP007243
Gene ID
856004
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Atg21p
Gene Symbol
ATG21
Synonyms
HSV1; MAI1
Alternate Names
Atg21p
Chromosome
XVI

Proteins

Atg21p
Refseq ID NP_015225
Protein GI 6325157
UniProt ID Q02887
mRNA ID NM_001183914
Length 496
RefSeq Status PROVISIONAL
MKVLQFNQDATCCVVAASSHQISIFNCDPFGKCFEIDTKNSKKKTSNNNGSASNSESRNNEESILITNGSRDRTDAEEEEDNEDNALVTGNILKEGEFVIEMLFSTSLIAIADRGQGLNKGKKLKIVNTKRKCTICEIVFPHEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYKRSQANSFSNASNTGTLEGDSANLNRVATNLLANATQKSVNGSNPSVRTRRNSLRSKIRPRMVLSNDDRSILCFTAYSSPKKNKPNSEALYDVVIYDTLNVTPVNYLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLCNLYQLAFDKSMTMIGCVGDTDTIHLFKLDDASNSLPGDNSSNGHWNEEEYILASNSNPSMGTPKEIPLSKPRIANYFSKKIKSSIPNQNLSRNFAYITVNESNRSCLGFPDEFPNQVYIASDDGTFSIYSIPSKPGECVLTKNNKFT

Gene Information

Entrez Gene ID
856004
Gene Name
Atg21p
Gene Symbol
ATG21
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:SGD C cytosol
GO:0005768 IDA:SGD C endosome
GO:0000329 IDA:SGD C fungal-type vacuole membrane
GO:0080025 IDA:SGD F phosphatidylinositol-3,5-bisphosphate binding
GO:0032258 IMP:SGD P CVT pathway
GO:0016236 IMP:SGD P macroautophagy
GO:0000422 IMP:SGD P mitochondrion degradation
GO:0034727 IMP:SGD P piecemeal microautophagy of nucleus
GO:0006497 IMP:SGD P protein lipidation
GO:0034497 IMP:SGD P protein localization to pre-autophagosomal structure
GO:0016050 IMP:SGD P vesicle organization

REACTOME Pathway Links

REACTOME Pathway ID Description
5618468 IRE1alpha activates chaperones
5618074 Metabolism of proteins
5618469 Unfolded Protein Response (UPR)
5618616 XBP1(S) activates chaperone genes

Domain Information

InterPro Annotations

Accession Description
IPR017986 WD40-repeat-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR001680 WD40_repeat

UniProt Annotations

Entry Information

Gene Name
Atg21p
Protein Entry
ATG21_YEAST
UniProt ID
Q02887
Species
Yeast (S288c)

Comments

Comment Type Description
Domain Contains a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2).
Domain The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway and for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium and in both its recruitment to and dissociation from the PAS under starvation conditions.
Function Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4- mediated cleavage. Essential for maturation of proaminopeptidase I. {ECO:0000269|PubMed:11536337, ECO:0000269|PubMed:11852075, ECO:0000269|PubMed:15155809, ECO:0000269|PubMed:15194695, ECO:0000269|PubMed:16876790, ECO:0000269|PubMed:18769150, ECO:0000269|PubMed:19793921, ECO:0000269|PubMed:20154084, ECO:0000269|PubMed:22108003}.
Miscellaneous Present with 6020 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the WD repeat SVP1 family. {ECO:0000305}.
Similarity Contains 3 WD repeats. {ECO:0000305}.
Subcellular Location Cytoplasm. Vacuole. Note=And perivacuolar punctate structures.

Identical and Related Proteins

Unique RefSeq proteins for LMP007243 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6325157 RefSeq NP_015225 496 Atg21p

Identical Sequences to LMP007243 proteins

Reference Database Accession Length Protein Name
GI:6325157 GenBank AAB68199.1 496 Ypl100wp [Saccharomyces cerevisiae]
GI:6325157 GenBank EIW07012.1 496 Atg21p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6325157 SwissProt Q02887.1 496 RecName: Full=Autophagy-related protein 21; AltName: Full=Cytoplasm to vacuole transport protein 21; AltName: Full=Homologous with SVP1 protein 1; AltName: Full=Maturation of proaminopeptidase I protein 1 [Saccharomyces cerevisiae S288c]
GI:6325157 Third Party Genbank DAA11332.1 496 TPA: Atg21p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007243 proteins

Reference Database Accession Length Protein Name
GI:6325157 GenBank EDV11120.1 496 hypothetical protein SCRG_02394 [Saccharomyces cerevisiae RM11-1a]
GI:6325157 GenBank EGA80480.1 496 Atg21p [Saccharomyces cerevisiae Lalvin QA23]
GI:6325157 GenBank EGA84553.1 496 Atg21p [Saccharomyces cerevisiae VL3]
GI:6325157 GenBank EWG85595.1 496 Atg21p [Saccharomyces cerevisiae R008]
GI:6325157 GenBank EWG88444.1 496 Atg21p [Saccharomyces cerevisiae P301]
GI:6325157 GenBank EWG92728.1 496 Atg21p [Saccharomyces cerevisiae R103]