LIPID MAPS

LMPD ID

LMP007228

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Gpi12p

Gene Symbol

GPI12

Synonyms

-

Chromosome

XIII

EC Number

3.5.1.89;

Gpi12p
Refseq ID	NP_014008
Protein GI	6323937
UniProt ID	P23797
mRNA ID	NM_001182788
Length	304
MKMLRRTKVNFSKLLYKITKLAIVLTILYIYFTPKIVSRNNASLQHIFPHKYGDYEINLVIAHPDDEVMFFSPIISQLNSYFPRTVPFNIICLSKGNAEGLGETRVRELNESAALLLHNERAVSVQVMDFQDGMDEIWDIDSITSSLSQKIDIKNHNLNQIIVTFDSYGVSNHINHKSCYAAVKKLVDDYAQPKTKRNEQPPHVTALYLRSYKNNIVLKYNSFIWEILKILYDLISPFRRIIQALPPNTAAEKDKLSLMNTHAQYVLAFATMLNAHESQVVWFRYGWWIFSRFVFVNEFDVYTY

Entrez Gene ID

Gene Name

Gpi12p

Gene Symbol

GPI12

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005789	ISS:SGD	C	endoplasmic reticulum membrane
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0000225	ISS:SGD	F	N-acetylglucosaminylphosphatidylinositol deacetylase activity
GO:0006506	ISS:SGD	P	GPI anchor biosynthetic process

KEGG Pathway ID	Description
M00065	GPI-anchor biosynthesis, core oligosaccharide
sce_M00065	GPI-anchor biosynthesis, core oligosaccharide
ko00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce01100	Metabolic pathways

REACTOME Pathway ID	Description
5618074	Metabolism of proteins
5618284	Post-translational modification: synthesis of GPI-anchored proteins
5618285	Post-translational protein modification
5618283	Synthesis of glycosylphosphatidylinositol (GPI)

Accession	Description
IPR003737	N-acetylglucosaminyl phosphatidylinositol deacetylase-related
IPR024078	Putative deacetylase LmbE-like domain

Gene Name

Gpi12p

Protein Entry

GPI12_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol + acetate.
Function	Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol.
Interaction	P23255:TAF2; NbExp=1; IntAct=EBI-7773, EBI-18862;
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Sequence Caution	Sequence=M59860; Type=Frameshift; Positions=64; Evidence= ;
Sequence Caution	Sequence=M59860; Type=Frameshift; Positions=64; Evidence={ECO:0000305};
Similarity	Belongs to the PIGL family
Similarity	Belongs to the PIGL family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane.