LIPID MAPS

LMPD ID

LMP007209

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase

Gene Symbol

COQ5

Synonyms

DBI56

Chromosome

XIII

EC Number

2.1.1.201

2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase
Refseq ID	NP_013597
Protein GI	6323526
UniProt ID	P49017
mRNA ID	NM_001182472
Length	307
MLISSRIVRSSLVNVPLRLSRCFTQAHRACKEEEVNSPLSSAAEQPEQKYTHFGSKTVLKSTKQKLVGDVFSSVANRYDLMNDVMSLGIHRLWKDHFINKLDAGKRPNSTTPLNFIDVAGGSGDIAFGLLDHAESKFGDTESTMDIVDINPDMLKEGEKRAMEQGKYFKDPRVRFLVSNGEKLEEIDSDSKDIYTVSFGIRNFTDIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIANDYDSYQYLVESIERFPDQETFKSMIEKAGFKSAGYESLTFGICAIHWGIKV

Entrez Gene ID

Gene Name

2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase

Gene Symbol

COQ5

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005759	IDA:SGD	C	mitochondrial matrix
GO:0043334	IMP:SGD	F	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0009060	IMP:SGD	P	aerobic respiration
GO:0006744	IMP:SGD	P	ubiquinone biosynthetic process

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
sce01100	Metabolic pathways
ko00130	Ubiquinone and other terpenoid-quinone biosynthesis
sce00130	Ubiquinone and other terpenoid-quinone biosynthesis
M00128	Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone
sce_M00128	Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone

BIOCYC Pathway ID	Description
ALL-CHORISMATE-YEAST-PWY	superpathway of chorismate metabolism
PWY-7235	superpathway of ubiquinol-6 biosynthesis
PWY-7235	superpathway of ubiquinol-6 biosynthesis (eukaryotic)
PWY-7230	ubiquinol-6 biosynthesis from 4-aminobenzoate
PWY-7230	ubiquinol-6 biosynthesis from 4-aminobenzoate (eukaryotic)
PWY3O-19	ubiquinol-6 biosynthesis from 4-hydroxybenzoate (eukaryotic)
PWY3O-19	ubiquinol-6 biosynthesis from 4-hydroxybenzoate (eukaryotic)
PWY-7233	ubiquinol-6 bypass biosynthesis
PWY-7233	ubiquinol-6 bypass biosynthesis (eukaryotic)

REACTOME Pathway ID	Description
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618642	Ubiquinol biosynthesis

Accession	Description
IPR029063	S-adenosyl-L-methionine-dependent methyltransferase
IPR004033	UbiE/COQ5 methyltransferase
IPR023576	UbiE/COQ5 methyltransferase, conserved site

Gene Name

2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase

Protein Entry

COQ5_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	S-adenosyl-L-methionine + 2-methoxy-6-all- trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6- methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. {ECO:0000255\|PROSITE-ProRule:PRU00940, ECO:0000269\|PubMed:9083049}.
Function	Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Miscellaneous	Present with 8100 molecules/cell in log phase SD medium
Miscellaneous	Present with 8100 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis.
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family. {ECO:0000255\|PROSITE- ProRule:PRU00940}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:9083049}.