Gene/Proteome Database (LMPD)

LMPD ID
LMP007192
Gene ID
855003
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
sterol 24-C-methyltransferase
Gene Symbol
ERG6
Synonyms
ISE1; LIS1; SED6; VID1
Chromosome
XIII
EC Number
2.1.1.41

Proteins

sterol 24-C-methyltransferase
Refseq ID NP_013706
Protein GI 6323635
UniProt ID P25087
mRNA ID NM_001182363
Length 383
MSETELRKRQAQFTRELHGDDIGKKTGLSALMSKNNSAQKEAVQKYLRNWDGRTDKDAEERRLEDYNEATHSYYNVVTDFYEYGWGSSFHFSRFYKGESFAASIARHEHYLAYKAGIQRGDLVLDVGCGVGGPAREIARFTGCNVIGLNNNDYQIAKAKYYAKKYNLSDQMDFVKGDFMKMDFEENTFDKVYAIEATCHAPKLEGVYSEIYKVLKPGGTFAVYEWVMTDKYDENNPEHRKIAYEIELGDGIPKMFHVDVARKALKNCGFEVLVSEDLADNDDEIPWYYPLTGEWKYVQNLANLATFFRTSYLGRQFTTAMVTVMEKLGLAPEGSKEVTAALENAAVGLVAGGKSKLFTPMMLFVARKPENAETPSQTSQEATQ

Gene Information

Entrez Gene ID
855003
Gene Name
sterol 24-C-methyltransferase
Gene Symbol
ERG6
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0005811 IDA:SGD C lipid particle
GO:0003838 IDA:SGD F sterol 24-C-methyltransferase activity
GO:0006696 IMP:SGD P ergosterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce01110 Biosynthesis of secondary metabolites
M00102 Ergocalciferol biosynthesis
sce_M00102 Ergocalciferol biosynthesis
sce01100 Metabolic pathways
ko00100 Steroid biosynthesis
sce00100 Steroid biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6075 ergosterol biosynthesis
PWY-6075 ergosterol biosynthesis I
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis I

Domain Information

InterPro Annotations

Accession Description
IPR025810 ERG6
IPR013216 Methyltransferase type 11
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
IPR013705 Sterol methyltransferase C-terminal

UniProt Annotations

Entry Information

Gene Name
sterol 24-C-methyltransferase
Protein Entry
ERG6_YEAST
UniProt ID
P25087
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + 5-alpha-cholesta- 8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5- alpha-cholest-8-en-3-beta-ol.
Function Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.
Interaction Q12066:YDL089W; NbExp=1; IntAct=EBI-6567, EBI-35877; Q12274:YOR097C; NbExp=1; IntAct=EBI-6567, EBI-33978;
Miscellaneous Present with 53800 molecules/cell in log phase SD medium
Miscellaneous Present with 53800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. {ECO:0000255|PROSITE-ProRule:PRU01022}.
Subunit Interacts with ERG28. {ECO:0000269|PubMed:15522820, ECO:0000269|PubMed:15995173}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007192 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323635 RefSeq NP_013706 383 sterol 24-C-methyltransferase

Identical Sequences to LMP007192 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007192 proteins

Reference Database Accession Length Protein Name