Gene/Proteome Database (LMPD)

LMPD ID
LMP007190
Gene ID
853107
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Pdx1p
Gene Symbol
PDX1
Synonyms
-
Alternate Names
Pdx1p
Chromosome
VII

Proteins

Pdx1p
Refseq ID NP_011709
Protein GI 6321632
UniProt ID P16451
mRNA ID NM_001181322
Length 410
RefSeq Status PROVISIONAL
MLSAISKVSTLKSCTRYLTKCNYHASAKLLAVKTFSMPAMSPTMEKGGIVSWKYKVGEPFSAGDVILEVETDKSQIDVEALDDGKLAKILKDEGSKDVDVGEPIAYIADVDDDLATIKLPQEANTANAKSIEIKKPSADSTEATQQHLKKATVTPIKTVDGSQANLEQTLLPSVSLLLAENNISKQKALKEIAPSGSNGRLLKGDVLAYLGKIPQDSVNKVTEFIKKNERLDLSNIKPIQLKPKIAEQAQTKAADKPKITPVEFEEQLVFHAPASIPFDKLSESLNSFMKEAYQFSHGTPLMDTNSKYFDPIFEDLVTLSPREPRFKFSYDLMQIPKANNMQDTYGQEDIFDLLTGSDATASSVRPVEKNLPEKNEYILALNVSVNNKKFNDAEAKAKRFLDYVRELESF

Gene Information

Entrez Gene ID
853107
Gene Name
Pdx1p
Gene Symbol
PDX1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005967 IDA:SGD C mitochondrial pyruvate dehydrogenase complex
GO:0005198 IDA:SGD F structural molecule activity
GO:0016746 IEA:InterPro F transferase activity, transferring acyl groups
GO:0006086 IDA:SGD P acetyl-CoA biosynthetic process from pyruvate

Domain Information

InterPro Annotations

Accession Description
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR000089 Biotin/lipoyl attachment
IPR004167 E3-binding domain
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
Pdx1p
Protein Entry
ODPX_YEAST
UniProt ID
P16451
Species
Yeast (S288c)

Comments

Comment Type Description
Function Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
Miscellaneous Present with 414 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
Similarity Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular Location Mitochondrion matrix.
Subunit Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.

Identical and Related Proteins

Unique RefSeq proteins for LMP007190 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6321632 RefSeq NP_011709 410 Pdx1p

Identical Sequences to LMP007190 proteins

Reference Database Accession Length Protein Name
GI:6321632 EMBL CAA97219.1 410 PDX1 [Saccharomyces cerevisiae]
GI:6321632 EMBL CBK51132.1 410 unnamed protein product [Saccharomyces cerevisiae]
GI:6321632 GenBank EIW10540.1 410 Pdx1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6321632 GenBank AGP21945.1 410 Sequence 110 from patent US 8465964
GI:6321632 GenBank AIB02140.1 410 Sequence 91 from patent US 8669094
GI:6321632 Third Party Genbank DAA08286.1 410 TPA: Pdx1p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007190 proteins

Reference Database Accession Length Protein Name
GI:6321632 DBBJ GAA23564.1 410 K7_Pdx1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6321632 GenBank AAT93002.1 410 YGR193C [Saccharomyces cerevisiae]
GI:6321632 GenBank EEU06532.1 410 Pdx1p [Saccharomyces cerevisiae JAY291]
GI:6321632 GenBank EWG86062.1 410 Pdx1p [Saccharomyces cerevisiae R008]
GI:6321632 GenBank EWG91141.1 410 Pdx1p [Saccharomyces cerevisiae P301]
GI:6321632 gnl McCuskerlabDuke 410 Pdx1p [Saccharomyces cerevisiae YJM993]